Q9BQ95: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

General Information

Protein names	- Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial - Protein SITPEC
Gene names	ECSIT
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BQ95

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial - Isoform 3 of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial - Isoform 4 of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Sequence View

        10         20         30         40         50         60
MSWVQATLLA RGLCRAWGGT CGAALTGTSI SQVPRRLPRG LHCSAAAHSS EQSLVPSPPE
        70         80         90        100        110        120
PRQRPTKALV PFEDLFGQAP GGERDKASFL QTVQKFAEHS VRKRGHIDFI YLALRKMREY
       130        140        150        160        170        180
GVERDLAVYN QLLNIFPKEV FRPRNIIQRI FVHYPRQQEC GIAVLEQMEN HGVMPNKETE
       190        200        210        220        230        240
FLLIQIFGRK SYPMLKLVRL KLWFPRFMNV NPFPVPRDLP QDPVELAMFG LRHMEPDLSA
       250        260        270        280        290        300
RVTIYQVPLP KDSTGAADPP QPHIVGIQSP DQQAALARHN PARPVFVEGP FSLWLRNKCV
       310        320        330        340        350        360
YYHILRADLL PPEEREVEET PEEWNLYYPM QLDLEYVRSG WDNYEFDINE VEEGPVFAMC
       370        380        390        400        410        420
MAGAHDQATM AKWIQGLQET NPTLAQIPVV FRLAGSTREL QTSSAGLEEP PLPEDHQEED
       430
DNLQRQQQGQ S         10         20         30         40         50         60
MSWVQATLLA RGLCRAWGGT CGAALTGTSI SQVPRRLPRG LHCSAAAHSS EQSLVPSPPE
        70         80         90        100        110        120
PRQRPTKALV PFEDLFGQAP GGERDKASFL QTVQKFAEHS VRKRGHIDFI YLALRKMREY
       130        140        150        160        170        180
GVERDLAVYN QLLNIFPKEV FRPRNIIQRI FVHYPRQQEC GIAVLEQMEN HGVMPNKETE
       190        200        210        220        230        240
FLLIQIFGRK SYPMLKLVRL KLWFPRFMNV NPFPVPRDLP QDPVELAMFG LRHMEPDLSA
       250        260        270        280        290        300
RVTIYQVPLP KDSTGAADPP QPHIVGIQSP DQQAALARHN PARPVFVEGP FSLWLRNKCV
       310        320        330        340        350        360
YYHILRADLL PPEEREVEET PEEWNLYYPM QLDLEYVRSG WDNYEFDINE VEEGPVFAMC
       370        380        390        400        410        420
MAGAHDQATM AKWIQGLQET NPTLAQIPVV FRLAGSTREL QTSSAGLEEP PLPEDHQEED
       430
DNLQRQQQGQ S         10         20         30         40         50         60
MSWVQATLLA RGLCRAWGGT CGAALTGTSI SQVPRRLPRG LHCSAAAHSS EQSLVPSPPE
        70         80         90        100        110        120
PRQRPTKALV PFEDLFGQAP GGERDKASFL QTVQKFAEHS VRKRGHIDFI YLALRKMREY
       130        140        150        160        170        180
GVERDLAVYN QLLNIFPKEV FRPRNIIQRI FVHYPRQQEC GIAVLEQMEN HGVMPNKETE
       190        200        210        220        230        240
FLLIQIFGRK SYPMLKLVRL KLWFPRFMNV NPFPVPRDLP QDPVELAMFG LRHMEPDLSA
       250        260        270        280        290        300
RVTIYQVPLP KDSTGAADPP QPHIVGIQSP DQQAALARHN PARPVFVEGP FSLWLRNKCV
       310        320        330        340        350        360
YYHILRADLL PPEEREVEET PEEWNLYYPM QLDLEYVRSG WDNYEFDINE VEEGPVFAMC
       370        380        390        400        410        420
MAGAHDQATM AKWIQGLQET NPTLAQIPVV FRLAGSTREL QTSSAGLEEP PLPEDHQEED
       430
DNLQRQQQGQ S

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BQ95-1-unknown	MSWVQA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73606
Q9BQ95-1-unknown	MSWVQA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73607
Q9BQ95-49-unknown	SSEQSL...	49	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BQ95-49-unknown	SSEQSL...	49		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9BQ95-49-unknown	SSEQSL...	49		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9BQ95-49-unknown	SSEQSL...	49	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115613
Q9BQ95-49-	SSEQSL...	49		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9BQ95-49-	SSEQSL...	49		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9BQ95-49-	SSEQSL...	49		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9BQ95-49-	SSEQSL...	49		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9BQ95-49-	SSEQSL...	49		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9BQ95-49-	SSEQSL...	49		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9BQ95-49-	SSEQSL...	49		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9BQ95-49-	SSEQSL...	49		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...QQGQS	431	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...QQGQS	431	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt69225

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)