Q9BRS2: Serine/threonine-protein kinase RIO1

General Information

Protein names	- Serine/threonine-protein kinase RIO1 - 2.7.11.1 {ECO:0000269\|PubMed:22072790} - 3.6.3.- - RIO kinase 1
Gene names	RIOK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BRS2

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDYRRLLMSR VVPGQFDDAD SSDSENRDLK TVKEKDDILF EDLQDNVNEN GEGEIEDEEE
        70         80         90        100        110        120
EGYDDDDDDW DWDEGVGKLA KGYVWNGGSN PQANRQTSDS SSAKMSTPAD KVLRKFENKI
       130        140        150        160        170        180
NLDKLNVTDS VINKVTEKSR QKEADMYRIK DKADRATVEQ VLDPRTRMIL FKMLTRGIIT
       190        200        210        220        230        240
EINGCISTGK EANVYHASTA NGESRAIKIY KTSILVFKDR DKYVSGEFRF RHGYCKGNPR
       250        260        270        280        290        300
KMVKTWAEKE MRNLIRLNTA EIPCPEPIML RSHVLVMSFI GKDDMPAPLL KNVQLSESKA
       310        320        330        340        350        360
RELYLQVIQY MRRMYQDARL VHADLSEFNM LYHGGGVYII DVSQSVEHDH PHALEFLRKD
       370        380        390        400        410        420
CANVNDFFMR HSVAVMTVRE LFEFVTDPSI THENMDAYLS KAMEIASQRT KEERSSQDHV
       430        440        450        460        470        480
DEEVFKRAYI PRTLNEVKNY ERDMDIIMKL KEEDMAMNAQ QDNILYQTVT GLKKDLSGVQ
       490        500        510        520        530        540
KVPALLENQV EERTCSDSED IGSSECSDTD SEEQGDHARP KKHTTDPDID KKERKKMVKE
       550        560
AQREKRKNKI PKHVKKRKEK TAKTKKGK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BRS2-1-unknown	MDYRRL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BRS2-124-unknown	KLNVTD...	124	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13186
Q9BRS2-130-	SVINKV...	130		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9BRS2-130-	SVINKV...	130		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9BRS2-130-	SVINKV...	130		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KINLDK	123	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13186
...TKKGK	568	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...TKKGK	568		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TKKGK	568		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...TKKGK	568		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TKKGK	568		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	123	NLDK.\|.KLNV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)