Q9BSJ8: Extended synaptotagmin-1 {ECO:0000305}
Protein names | - Extended synaptotagmin-1 {ECO:0000305} - E-Syt1 {ECO:0000303|PubMed:29469807} - Membrane-bound C2 domain-containing protein |
---|---|
Gene names | ESYT1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9BSJ8 |
13
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MERSPGEGPS PSPMDQPSAP SDPTDQPPAA HAKPDPGSGG QPAGPGAAGE ALAVLTSFGR
70 80 90 100 110 120
RLLVLIPVYL AGAVGLSVGF VLFGLALYLG WRRVRDEKER SLRAARQLLD DEEQLTAKTL
130 140 150 160 170 180
YMSHRELPAW VSFPDVEKAE WLNKIVAQVW PFLGQYMEKL LAETVAPAVR GSNPHLQTFT
190 200 210 220 230 240
FTRVELGEKP LRIIGVKVHP GQRKEQILLD LNISYVGDVQ IDVEVKKYFC KAGVKGMQLH
250 260 270 280 290 300
GVLRVILEPL IGDLPFVGAV SMFFIRRPTL DINWTGMTNL LDIPGLSSLS DTMIMDSIAA
310 320 330 340 350 360
FLVLPNRLLV PLVPDLQDVA QLRSPLPRGI IRIHLLAARG LSSKDKYVKG LIEGKSDPYA
370 380 390 400 410 420
LVRLGTQTFC SRVIDEELNP QWGETYEVMV HEVPGQEIEV EVFDKDPDKD DFLGRMKLDV
430 440 450 460 470 480
GKVLQASVLD DWFPLQGGQG QVHLRLEWLS LLSDAEKLEQ VLQWNWGVSS RPDPPSAAIL
490 500 510 520 530 540
VVYLDRAQDL PLKKGNKEPN PMVQLSIQDV TQESKAVYST NCPVWEEAFR FFLQDPQSQE
550 560 570 580 590 600
LDVQVKDDSR ALTLGALTLP LARLLTAPEL ILDQWFQLSS SGPNSRLYMK LVMRILYLDS
610 620 630 640 650 660
SEICFPTVPG CPGAWDVDSE NPQRGSSVDA PPRPCHTTPD SQFGTEHVLR IHVLEAQDLI
670 680 690 700 710 720
AKDRFLGGLV KGKSDPYVKL KLAGRSFRSH VVREDLNPRW NEVFEVIVTS VPGQELEVEV
730 740 750 760 770 780
FDKDLDKDDF LGRCKVRLTT VLNSGFLDEW LTLEDVPSGR LHLRLERLTP RPTAAELEEV
790 800 810 820 830 840
LQVNSLIQTQ KSAELAAALL SIYMERAEDL PLRKGTKHLS PYATLTVGDS SHKTKTISQT
850 860 870 880 890 900
SAPVWDESAS FLIRKPHTES LELQVRGEGT GVLGSLSLPL SELLVADQLC LDRWFTLSSG
910 920 930 940 950 960
QGQVLLRAQL GILVSQHSGV EAHSHSYSHS SSSLSEEPEL SGGPPHITSS APELRQRLTH
970 980 990 1000 1010 1020
VDSPLEAPAG PLGQVKLTLW YYSEERKLVS IVHGCRSLRQ NGRDPPDPYV SLLLLPDKNR
1030 1040 1050 1060 1070 1080
GTKRRTSQKK RTLSPEFNER FEWELPLDEA QRRKLDVSVK SNSSFMSRER ELLGKVQLDL
1090 1100
AETDLSQGVA RWYDLMDNKD KGSS
Isoforms
- Isoform 2 of Extended synaptotagmin-1Sequence View
10 20 30 40 50 60
MERSPGEGPS PSPMDQPSAP SDPTDQPPAA HAKPDPGSGG QPAGPGAAGE ALAVLTSFGR
70 80 90 100 110 120
RLLVLIPVYL AGAVGLSVGF VLFGLALYLG WRRVRDEKER SLRAARQLLD DEEQLTAKTL
130 140 150 160 170 180
YMSHRELPAW VSFPDVEKAE WLNKIVAQVW PFLGQYMEKL LAETVAPAVR GSNPHLQTFT
190 200 210 220 230 240
FTRVELGEKP LRIIGVKVHP GQRKEQILLD LNISYVGDVQ IDVEVKKYFC KAGVKGMQLH
250 260 270 280 290 300
GVLRVILEPL IGDLPFVGAV SMFFIRRPTL DINWTGMTNL LDIPGLSSLS DTMIMDSIAA
310 320 330 340 350 360
FLVLPNRLLV PLVPDLQDVA QLRSPLPRGI IRIHLLAARG LSSKDKYVKG LIEGKSDPYA
370 380 390 400 410 420
LVRLGTQTFC SRVIDEELNP QWGETYEVMV HEVPGQEIEV EVFDKDPDKD DFLGRMKLDV
430 440 450 460 470 480
GKVLQASVLD DWFPLQGGQG QVHLRLEWLS LLSDAEKLEQ VLQWNWGVSS RPDPPSAAIL
490 500 510 520 530 540
VVYLDRAQDL PLKKGNKEPN PMVQLSIQDV TQESKAVYST NCPVWEEAFR FFLQDPQSQE
550 560 570 580 590 600
LDVQVKDDSR ALTLGALTLP LARLLTAPEL ILDQWFQLSS SGPNSRLYMK LVMRILYLDS
610 620 630 640 650 660
SEICFPTVPG CPGAWDVDSE NPQRGSSVDA PPRPCHTTPD SQFGTEHVLR IHVLEAQDLI
670 680 690 700 710 720
AKDRFLGGLV KGKSDPYVKL KLAGRSFRSH VVREDLNPRW NEVFEVIVTS VPGQELEVEV
730 740 750 760 770 780
FDKDLDKDDF LGRCKVRLTT VLNSGFLDEW LTLEDVPSGR LHLRLERLTP RPTAAELEEV
790 800 810 820 830 840
LQVNSLIQTQ KSAELAAALL SIYMERAEDL PLRKGTKHLS PYATLTVGDS SHKTKTISQT
850 860 870 880 890 900
SAPVWDESAS FLIRKPHTES LELQVRGEGT GVLGSLSLPL SELLVADQLC LDRWFTLSSG
910 920 930 940 950 960
QGQVLLRAQL GILVSQHSGV EAHSHSYSHS SSSLSEEPEL SGGPPHITSS APELRQRLTH
970 980 990 1000 1010 1020
VDSPLEAPAG PLGQVKLTLW YYSEERKLVS IVHGCRSLRQ NGRDPPDPYV SLLLLPDKNR
1030 1040 1050 1060 1070 1080
GTKRRTSQKK RTLSPEFNER FEWELPLDEA QRRKLDVSVK SNSSFMSRER ELLGKVQLDL
1090 1100
AETDLSQGVA RWYDLMDNKD KGSS
Protein Neighborhood
Domains & Features
13 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9BSJ8-1-Acetylation | MERSPG... | 1 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q9BSJ8-1-Acetylation | MERSPG... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt95905 | ||
Q9BSJ8-1-unknown | MERSPG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt74245 | |||
Q9BSJ8-350-unknown | GLIEGK... | 350 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168142 | |||
Q9BSJ8-350- | GLIEGK... | 350 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q9BSJ8-350- | GLIEGK... | 350 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9BSJ8-437-unknown | GGQGQV... | 437 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8051 | |||
Q9BSJ8-437-unknown | GGQGQV... | 437 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152589 | |||
Q9BSJ8-506-unknown | SIQDVT... | 506 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177855 | |||
Q9BSJ8-506- | SIQDVT... | 506 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9BSJ8-641-unknown | SQFGTE... | 641 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176085 | |||
Q9BSJ8-641- | SQFGTE... | 641 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q9BSJ8-641- | SQFGTE... | 641 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9BSJ8-689- | SHVVRE... | 689 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9BSJ8-689-unknown | SHVVRE... | 689 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177857 | |||
Q9BSJ8-926-unknown | SYSHSS... | 926 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173964 | |||
Q9BSJ8-926- | SYSHSS... | 926 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...WFPLQG | 436 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8051 | |||
...WFPLQG | 436 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136006 | |||
...DKGSS | 1104 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...DKGSS | 1104 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69863 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATS_HUMAN | 436 | PLQG.|.GGQG | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|