Q9BU89: Deoxyhypusine hydroxylase {ECO:0000255|HAMAP-Rule:MF_03101, ECO:0000303|PubMed:16533814}

General Information

Protein names	- Deoxyhypusine hydroxylase {ECO:0000255\|HAMAP-Rule:MF_03101, ECO:0000303\|PubMed:16533814} - hDOHH {ECO:0000303\|PubMed:19706422} - 1.14.99.29 {ECO:0000255\|HAMAP-Rule:MF_03101, ECO:0000269\|PubMed:16371467, ECO:0000269\|PubMed:16533814, ECO:0000269\|PubMed:19706422} - Deoxyhypusine dioxygenase {ECO:0000255\|HAMAP-Rule:MF_03101} - Deoxyhypusine monooxygenase {ECO:0000255\|HAMAP-Rule:MF_03101} - HEAT-like repeat-containing protein 1 {ECO:0000303\|PubMed:19706422}
Gene names	DOHH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BU89

6 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVTEQEVDAI GQTLVDPKQP LQARFRALFT LRGLGGPGAI AWISQAFDDD SALLKHELAY
        70         80         90        100        110        120
CLGQMQDARA IPMLVDVLQD TRQEPMVRHE AGEALGAIGD PEVLEILKQY SSDPVIEVAE
       130        140        150        160        170        180
TCQLAVRRLE WLQQHGGEPA AGPYLSVDPA PPAEERDVGR LREALLDESR PLFERYRAMF
       190        200        210        220        230        240
ALRNAGGEEA ALALAEGLHC GSALFRHEVG YVLGQLQHEA AVPQLAAALA RCTENPMVRH
       250        260        270        280        290        300
ECAEALGAIA RPACLAALQA HADDPERVVR ESCEVALDMY EHETGRAFQY ADGLEQLRGA

PS

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BU89-1-	MVTEQE...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9BU89-1-	MVTEQE...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9BU89-1-	MVTEQE...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9BU89-1-	MVTEQE...	1			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9BU89-1-	MVTEQE...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9BU89-1-Acetylation	MVTEQE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BU89-1-Acetylation	MVTEQE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9BU89-1-Acetylation	MVTEQE...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9BU89-1-Acetylation	MVTEQE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9BU89-2-unknown	VTEQEV...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9BU89-2-	VTEQEV...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9BU89-9-	AIGQTL...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9BU89-9-	AIGQTL...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9BU89-9-	AIGQTL...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9BU89-9-	AIGQTL...	9			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9BU89-9-	AIGQTL...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9BU89-9-	AIGQTL...	9			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9BU89-97-	AIGDPE...	97			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...EAAVPQ	223	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464905
	...RGAPS	302	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)