Q9BUT1: 3-hydroxybutyrate dehydrogenase type 2

General Information

Protein names	- 3-hydroxybutyrate dehydrogenase type 2 - 1.1.1.- - 1.1.1.30 {ECO:0000269\|PubMed:16380372} - Dehydrogenase/reductase SDR family member 6 - Oxidoreductase UCPA - R-beta-hydroxybutyrate dehydrogenase - Short chain dehydrogenase/reductase family 15C member 1
Gene names	BDH2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BUT1

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of 3-hydroxybutyrate dehydrogenase type 2 - Isoform 3 of 3-hydroxybutyrate dehydrogenase type 2

Sequence View

        10         20         30         40         50         60
MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT
        70         80         90        100        110        120
KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM
       130        140        150        160        170        180
LAQKSGNIIN MSSVASSVKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV
       190        200        210        220        230        240
DTPSLQERIQ ARGNPEEARN DFLKRQKTGR FATAEEIAML CVYLASDESA YVTGNPVIID

GGWSL         10         20         30         40         50         60
MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT
        70         80         90        100        110        120
KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM
       130        140        150        160        170        180
LAQKSGNIIN MSSVASSVKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV
       190        200        210        220        230        240
DTPSLQERIQ ARGNPEEARN DFLKRQKTGR FATAEEIAML CVYLASDESA YVTGNPVIID

GGWSL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9BUT1-1-unknown	MGRLDG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9BUT1-1-unknown	MGRLDG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68350
Q9BUT1-48-unknown	KYPGIQ...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8063
Q9BUT1-48-unknown	KYPGIQ...	48	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139011
Q9BUT1-56-unknown	VLDVTK...	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10529
Q9BUT1-56-unknown	VLDVTK...	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139576
Q9BUT1-102-unknown	MNLNVR...	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68351
Q9BUT1-102-unknown	MNLNVR...	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109964

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LQELEK	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8063
...LQELEK	47	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122080
...GIQTRV	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10529
...GIQTRV	55	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122668
...GGWSL	245	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GGWSL	245	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63969

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	47	ELEK.\|.KYPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAA_HUMAN	55	QTRV.\|.VLDV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)