Q9BVS4: Serine/threonine-protein kinase RIO2

General Information

Protein names	- Serine/threonine-protein kinase RIO2 - 2.7.11.1 {ECO:0000269\|PubMed:19564402, ECO:0000269\|PubMed:21880710} - RIO kinase 2
Gene names	RIOK2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BVS4

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGKVNVAKLR YMSRDDFRVL TAVEMGMKNH EIVPGSLIAS IASLKHGGCN KVLRELVKHK
        70         80         90        100        110        120
LIAWERTKTV QGYRLTNAGY DYLALKTLSS RQVVESVGNQ MGVGKESDIY IVANEEGQQF
       130        140        150        160        170        180
ALKLHRLGRT SFRNLKNKRD YHKHRHNVSW LYLSRLSAMK EFAYMKALYE RKFPVPKPID
       190        200        210        220        230        240
YNRHAVVMEL INGYPLCQIH HVEDPASVYD EAMELIVKLA NHGLIHGDFN EFNLILDESD
       250        260        270        280        290        300
HITMIDFPQM VSTSHPNAEW YFDRDVKCIK DFFMKRFSYE SELFPTFKDI RREDTLDVEV
       310        320        330        340        350        360
SASGYTKEMQ ADDELLHPLG PDDKNIETKE GSEFSFSDGE VAEKAEVYGS ENESERNCLE
       370        380        390        400        410        420
ESEGCYCRSS GDPEQIKEDS LSEESADARS FEMTEFNQAL EEIKGQVVEN NSVTEFSEEK
       430        440        450        460        470        480
NRTENYNRQD GQRVQGGVPA GSDEYEDECP HLIALSSLNR EFRPFRDEEN VGAMNQYRTR
       490        500        510        520        530        540
TLSITSSGSA VSCSTIPPEL VKQKVKRQLT KQQKSAVRRR LQKGEANIFT KQRRENMQNI
       550
KSSLEAASFW GE

Isoforms

- Isoform 2 of Serine/threonine-protein kinase RIO2

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BVS4-1-unknown	MGKVNV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BVS4-1-unknown	MGKVNV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87779
Q9BVS4-2-unknown	GKVNVA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9BVS4-2-unknown	GKVNVA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9BVS4-2-unknown	GKVNVA...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162975
Q9BVS4-380-unknown	SLSEES...	380	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13227
Q9BVS4-380-unknown	SLSEES...	380		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9BVS4-380-unknown	SLSEES...	380	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151623
Q9BVS4-380-	SLSEES...	380		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9BVS4-412-unknown	SVTEFS...	412	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13229
Q9BVS4-412-unknown	SVTEFS...	412	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152194
Q9BVS4-412-	SVTEFS...	412		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9BVS4-412-	SVTEFS...	412		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QIKEDS	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13227
...QIKEDS	379	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135027
...VVENNS	411	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13229
...VVENNS	411	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135604
...SFWGE	552	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	379	KEDS.\|.SLSE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	411	ENNS.\|.SVTE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)