TopFIND 4.0

Q9BXM7: Serine/threonine-protein kinase PINK1, mitochondrial

General Information

Protein names
- Serine/threonine-protein kinase PINK1, mitochondrial
- 2.7.11.1 {ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582}
- BRPK
- PTEN-induced putative kinase protein 1
Gene names PINK1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9BXM7

2

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAVRQALGRG LQLGRALLLR FTGKPGRAYG LGRPGPAAGC VRGERPGWAA GPGAEPRRVG 
        70         80         90        100        110        120 
LGLPNRLRFF RQSVAGLAAR LQRQFVVRAW GCAGPCGRAV FLAFGLGLGL IEEKQAESRR 
       130        140        150        160        170        180 
AVSACQEIQA IFTQKSKPGP DPLDTRRLQG FRLEEYLIGQ SIGKGCSAAV YEATMPTLPQ 
       190        200        210        220        230        240 
NLEVTKSTGL LPGRGPGTSA PGEGQERAPG APAFPLAIKM MWNISAGSSS EAILNTMSQE 
       250        260        270        280        290        300 
LVPASRVALA GEYGAVTYRK SKRGPKQLAP HPNIIRVLRA FTSSVPLLPG ALVDYPDVLP 
       310        320        330        340        350        360 
SRLHPEGLGH GRTLFLVMKN YPCTLRQYLC VNTPSPRLAA MMLLQLLEGV DHLVQQGIAH 
       370        380        390        400        410        420 
RDLKSDNILV ELDPDGCPWL VIADFGCCLA DESIGLQLPF SSWYVDRGGN GCLMAPEVST 
       430        440        450        460        470        480 
ARPGPRAVID YSKADAWAVG AIAYEIFGLV NPFYGQGKAH LESRSYQEAQ LPALPESVPP 
       490        500        510        520        530        540 
DVRQLVRALL QREASKRPSA RVAANVLHLS LWGEHILALK NLKLDKMVGW LLQQSAATLL 
       550        560        570        580    
ANRLTEKCCV ETKMKMLFLA NLECETLCQA ALLLCSWRAA L

Isoforms

- Isoform 2 of Serine/threonine-protein kinase PINK1, mitochondrial

Sequence View

        10         20         30         40         50         60 
MAVRQALGRG LQLGRALLLR FTGKPGRAYG LGRPGPAAGC VRGERPGWAA GPGAEPRRVG 
        70         80         90        100        110        120 
LGLPNRLRFF RQSVAGLAAR LQRQFVVRAW GCAGPCGRAV FLAFGLGLGL IEEKQAESRR 
       130        140        150        160        170        180 
AVSACQEIQA IFTQKSKPGP DPLDTRRLQG FRLEEYLIGQ SIGKGCSAAV YEATMPTLPQ 
       190        200        210        220        230        240 
NLEVTKSTGL LPGRGPGTSA PGEGQERAPG APAFPLAIKM MWNISAGSSS EAILNTMSQE 
       250        260        270        280        290        300 
LVPASRVALA GEYGAVTYRK SKRGPKQLAP HPNIIRVLRA FTSSVPLLPG ALVDYPDVLP 
       310        320        330        340        350        360 
SRLHPEGLGH GRTLFLVMKN YPCTLRQYLC VNTPSPRLAA MMLLQLLEGV DHLVQQGIAH 
       370        380        390        400        410        420 
RDLKSDNILV ELDPDGCPWL VIADFGCCLA DESIGLQLPF SSWYVDRGGN GCLMAPEVST 
       430        440        450        460        470        480 
ARPGPRAVID YSKADAWAVG AIAYEIFGLV NPFYGQGKAH LESRSYQEAQ LPALPESVPP 
       490        500        510        520        530        540 
DVRQLVRALL QREASKRPSA RVAANVLHLS LWGEHILALK NLKLDKMVGW LLQQSAATLL 
       550        560        570        580    
ANRLTEKCCV ETKMKMLFLA NLECETLCQA ALLLCSWRAA L



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(REFRESH)

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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9BXM7-78-unknown AARLQR... 78 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9BXM7-104-unknown FGLGLG... 104 inferred from cleavage unknown TopFIND Inferred from cleavage TC26787

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)