Q9H300: Presenilins-associated rhomboid-like protein, mitochondrial

General Information

Protein names	- Presenilins-associated rhomboid-like protein, mitochondrial - 3.4.21.105 - Mitochondrial intramembrane cleaving protease PARL - P-beta - Pbeta
Gene names	PARL
Organism	Homo sapiens
Protease Family	S54.009
Protease ID	S54.009
Chromosome location
UniProt ID	Q9H300

3 N-termini

3 C-termini

2 Cleavages

5 Substrates

Sequence

        10         20         30         40         50         60
MAWRGWAQRG WGCGQAWGAS VGGRSCEELT AVLTPPQLLG RRFNFFIQQK CGFRKAPRKV
        70         80         90        100        110        120
EPRRSDPGTS GEAYKRSALI PPVEETVFYP SPYPIRSLIK PLFFTVGFTG CAFGSAAIWQ
       130        140        150        160        170        180
YESLKSRVQS YFDGIKADWL DSIRPQKEGD FRKEINKWWN NLSDGQRTVT GIIAANVLVF
       190        200        210        220        230        240
CLWRVPSLQR TMIRYFTSNP ASKVLCSPML LSTFSHFSLF HMAANMYVLW SFSSSIVNIL
       250        260        270        280        290        300
GQEQFMAVYL SAGVISNFVS YVGKVATGRY GPSLGASGAI MTVLAAVCTK IPEGRLAIIF
       310        320        330        340        350        360
LPMFTFTAGN ALKAIIAMDT AGMILGWKFF DHAAHLGGAL FGIWYVTYGH ELIWKNREPL
       370
VKIWHEIRTN GPKKGGGSK

Isoforms

- Isoform 2 of Presenilins-associated rhomboid-like protein, mitochondrial

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 5 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9H300-1-unknown	MAWRGW...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84318
Q9H300-53-unknown	FRKAPR...	53	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H300-53-unknown	FRKAPR...	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26788
Q9H300-53-unknown	FRKAPR...	53	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115662
Q9H300-78-unknown	ALIPPV...	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26790
Q9H300-78-unknown	ALIPPV...	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141192

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QQKCGF	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26788
...QQKCGF	52	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122495
...AYKRSA	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26790
...AYKRSA	77	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124352
...GGGSK	379	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GGGSK	379	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79936

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PARL_HUMAN	52	KCGF.\|.FRKA	inferred from experiment	unknown	MEROPS	Pellegrini L	Sik A et al.:Self-regulated cleavage of the ... (S54.009)	14732705,
PARL_HUMAN	77	KRSA.\|.ALIP	inferred from experiment	unknown	MEROPS	Pellegrini L	Sik A et al.:Self-regulated cleavage of the ... (S54.009)	14732705,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PARL_HUMAN	52	KCGF.\|.FRKA	inferred from experiment	unknown	MEROPS	Pellegrini L	Sik A et al.:Self-regulated cleavage of the ... (S54.009)	14732705,
PARL-Isoform2_HUMAN	52	KCGF.\|.FRKA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26788
PARL_HUMAN	77	KRSA.\|.ALIP	inferred from experiment	unknown	MEROPS	Pellegrini L	Sik A et al.:Self-regulated cleavage of the ... (S54.009)	14732705,
PARL-Isoform2_HUMAN	77	KRSA.\|.ALIP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26790
PINK1_HUMAN	103	FLAF.\|.FGLG	inferred from experiment	unknown	MEROPS	Wood NW	Deas E et al.:PINK1 cleavage at position A103... (S54.009)	21138942,