Q9H078: Caseinolytic peptidase B protein homolog

General Information

Protein names	- Caseinolytic peptidase B protein homolog - 3.6.1.3 {ECO:0000269\|PubMed:25597510} - Suppressor of potassium transport defect 3
Gene names	CLPB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H078

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Caseinolytic peptidase B protein homolog - Isoform 3 of Caseinolytic peptidase B protein homolog - Isoform 4 of Caseinolytic peptidase B protein homolog - Isoform 5 of Caseinolytic peptidase B protein homolog

Sequence View

        10         20         30         40         50         60
MLGSLVLRRK ALAPRLLLRL LRSPTLRGHG GASGRNVTTG SLGEPQWLRV ATGGRPGTSP
        70         80         90        100        110        120
ALFSGRGAAT GGRQGGRFDT KCLAAATWGR LPGPEETLPG QDSWNGVPSR AGLGMCALAA
       130        140        150        160        170        180
ALVVHCYSKS PSNKDAALLE AARANNMQEV SRLLSEGADV NAKHRLGWTA LMVAAINRNN
       190        200        210        220        230        240
SVVQVLLAAG ADPNLGDDFS SVYKTAKEQG IHSLEDGGQD GASRHITNQW TSALEFRRWL
       250        260        270        280        290        300
GLPAGVLITR EDDFNNRLNN RASFKGCTAL HYAVLADDYR TVKELLDGGA NPLQRNEMGH
       310        320        330        340        350        360
TPLDYAREGE VMKLLRTSEA KYQEKQRKRE AEERRRFPLE QRLKEHIIGQ ESAIATVGAA
       370        380        390        400        410        420
IRRKENGWYD EEHPLVFLFL GSSGIGKTEL AKQTAKYMHK DAKKGFIRLD MSEFQERHEV
       430        440        450        460        470        480
AKFIGSPPGY VGHEEGGQLT KKLKQCPNAV VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK
       490        500        510        520        530        540
GKTIDCKDAI FIMTSNVASD EIAQHALQLR QEALEMSRNR IAENLGDVQI SDKITISKNF
       550        560        570        580        590        600
KENVIRPILK AHFRRDEFLG RINEIVYFLP FCHSELIQLV NKELNFWAKR AKQRHNITLL
       610        620        630        640        650        660
WDREVADVLV DGYNVHYGAR SIKHEVERRV VNQLAAAYEQ DLLPGGCTLR ITVEDSDKQL
       670        680        690        700
LKSPELPSPQ AEKRLPKLRL EIIDKDSKTR RLDIRAPLHP EKVCNTI         10         20         30         40         50         60
MLGSLVLRRK ALAPRLLLRL LRSPTLRGHG GASGRNVTTG SLGEPQWLRV ATGGRPGTSP
        70         80         90        100        110        120
ALFSGRGAAT GGRQGGRFDT KCLAAATWGR LPGPEETLPG QDSWNGVPSR AGLGMCALAA
       130        140        150        160        170        180
ALVVHCYSKS PSNKDAALLE AARANNMQEV SRLLSEGADV NAKHRLGWTA LMVAAINRNN
       190        200        210        220        230        240
SVVQVLLAAG ADPNLGDDFS SVYKTAKEQG IHSLEDGGQD GASRHITNQW TSALEFRRWL
       250        260        270        280        290        300
GLPAGVLITR EDDFNNRLNN RASFKGCTAL HYAVLADDYR TVKELLDGGA NPLQRNEMGH
       310        320        330        340        350        360
TPLDYAREGE VMKLLRTSEA KYQEKQRKRE AEERRRFPLE QRLKEHIIGQ ESAIATVGAA
       370        380        390        400        410        420
IRRKENGWYD EEHPLVFLFL GSSGIGKTEL AKQTAKYMHK DAKKGFIRLD MSEFQERHEV
       430        440        450        460        470        480
AKFIGSPPGY VGHEEGGQLT KKLKQCPNAV VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK
       490        500        510        520        530        540
GKTIDCKDAI FIMTSNVASD EIAQHALQLR QEALEMSRNR IAENLGDVQI SDKITISKNF
       550        560        570        580        590        600
KENVIRPILK AHFRRDEFLG RINEIVYFLP FCHSELIQLV NKELNFWAKR AKQRHNITLL
       610        620        630        640        650        660
WDREVADVLV DGYNVHYGAR SIKHEVERRV VNQLAAAYEQ DLLPGGCTLR ITVEDSDKQL
       670        680        690        700
LKSPELPSPQ AEKRLPKLRL EIIDKDSKTR RLDIRAPLHP EKVCNTI         10         20         30         40         50         60
MLGSLVLRRK ALAPRLLLRL LRSPTLRGHG GASGRNVTTG SLGEPQWLRV ATGGRPGTSP
        70         80         90        100        110        120
ALFSGRGAAT GGRQGGRFDT KCLAAATWGR LPGPEETLPG QDSWNGVPSR AGLGMCALAA
       130        140        150        160        170        180
ALVVHCYSKS PSNKDAALLE AARANNMQEV SRLLSEGADV NAKHRLGWTA LMVAAINRNN
       190        200        210        220        230        240
SVVQVLLAAG ADPNLGDDFS SVYKTAKEQG IHSLEDGGQD GASRHITNQW TSALEFRRWL
       250        260        270        280        290        300
GLPAGVLITR EDDFNNRLNN RASFKGCTAL HYAVLADDYR TVKELLDGGA NPLQRNEMGH
       310        320        330        340        350        360
TPLDYAREGE VMKLLRTSEA KYQEKQRKRE AEERRRFPLE QRLKEHIIGQ ESAIATVGAA
       370        380        390        400        410        420
IRRKENGWYD EEHPLVFLFL GSSGIGKTEL AKQTAKYMHK DAKKGFIRLD MSEFQERHEV
       430        440        450        460        470        480
AKFIGSPPGY VGHEEGGQLT KKLKQCPNAV VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK
       490        500        510        520        530        540
GKTIDCKDAI FIMTSNVASD EIAQHALQLR QEALEMSRNR IAENLGDVQI SDKITISKNF
       550        560        570        580        590        600
KENVIRPILK AHFRRDEFLG RINEIVYFLP FCHSELIQLV NKELNFWAKR AKQRHNITLL
       610        620        630        640        650        660
WDREVADVLV DGYNVHYGAR SIKHEVERRV VNQLAAAYEQ DLLPGGCTLR ITVEDSDKQL
       670        680        690        700
LKSPELPSPQ AEKRLPKLRL EIIDKDSKTR RLDIRAPLHP EKVCNTI         10         20         30         40         50         60
MLGSLVLRRK ALAPRLLLRL LRSPTLRGHG GASGRNVTTG SLGEPQWLRV ATGGRPGTSP
        70         80         90        100        110        120
ALFSGRGAAT GGRQGGRFDT KCLAAATWGR LPGPEETLPG QDSWNGVPSR AGLGMCALAA
       130        140        150        160        170        180
ALVVHCYSKS PSNKDAALLE AARANNMQEV SRLLSEGADV NAKHRLGWTA LMVAAINRNN
       190        200        210        220        230        240
SVVQVLLAAG ADPNLGDDFS SVYKTAKEQG IHSLEDGGQD GASRHITNQW TSALEFRRWL
       250        260        270        280        290        300
GLPAGVLITR EDDFNNRLNN RASFKGCTAL HYAVLADDYR TVKELLDGGA NPLQRNEMGH
       310        320        330        340        350        360
TPLDYAREGE VMKLLRTSEA KYQEKQRKRE AEERRRFPLE QRLKEHIIGQ ESAIATVGAA
       370        380        390        400        410        420
IRRKENGWYD EEHPLVFLFL GSSGIGKTEL AKQTAKYMHK DAKKGFIRLD MSEFQERHEV
       430        440        450        460        470        480
AKFIGSPPGY VGHEEGGQLT KKLKQCPNAV VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK
       490        500        510        520        530        540
GKTIDCKDAI FIMTSNVASD EIAQHALQLR QEALEMSRNR IAENLGDVQI SDKITISKNF
       550        560        570        580        590        600
KENVIRPILK AHFRRDEFLG RINEIVYFLP FCHSELIQLV NKELNFWAKR AKQRHNITLL
       610        620        630        640        650        660
WDREVADVLV DGYNVHYGAR SIKHEVERRV VNQLAAAYEQ DLLPGGCTLR ITVEDSDKQL
       670        680        690        700
LKSPELPSPQ AEKRLPKLRL EIIDKDSKTR RLDIRAPLHP EKVCNTI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H078-1-unknown	MLGSLV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H078-1-unknown	MLGSLV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71017
Q9H078-1-unknown	MLGSLV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71018
Q9H078-127-	YSKSPS...	127		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9H078-127-	YSKSPS...	127		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H078-127-	YSKSPS...	127		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9H078-127-unknown	YSKSPS...	127	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167844
Q9H078-127-unknown	YSKSPS...	127	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167845
Q9H078-662-unknown	KSPELP...	662	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14985
Q9H078-662-unknown	KSPELP...	662	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154624
Q9H078-662-unknown	KSPELP...	662	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154878
Q9H078-662-unknown	KSPELP...	662	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155097

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DKQLLK	661	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14985
...DKQLLK	661	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138049
...DKQLLK	661	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138307
...DKQLLK	661	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138524
...VCNTI	707	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VCNTI	707	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66636
...VCNTI	707	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66637
...VCNTI	707	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66635

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	661	QLLK.\|.KSPE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)