Q9H0C8: Integrin-linked kinase-associated serine/threonine phosphatase 2C

General Information

Protein names	- Integrin-linked kinase-associated serine/threonine phosphatase 2C - ILKAP - 3.1.3.16
Gene names	ILKAP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H0C8

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDLFGDLPEP ERSPRPAAGK EAQKGPLLFD DLPPASSTDS GSGGPLLFDD LPPASSGDSG
        70         80         90        100        110        120
SLATSISQMV KTEGKGAKRK TSEEEKNGSE ELVEKKVCKA SSVIFGLKGY VAERKGEREE
       130        140        150        160        170        180
MQDAHVILND ITEECRPPSS LITRVSYFAV FDGHGGIRAS KFAAQNLHQN LIRKFPKGDV
       190        200        210        220        230        240
ISVEKTVKRC LLDTFKHTDE EFLKQASSQK PAWKDGSTAT CVLAVDNILY IANLGDSRAI
       250        260        270        280        290        300
LCRYNEESQK HAALSLSKEH NPTQYEERMR IQKAGGNVRD GRVLGVLEVS RSIGDGQYKR
       310        320        330        340        350        360
CGVTSVPDIR RCQLTPNDRF ILLACDGLFK VFTPEEAVNF ILSCLEDEKI QTREGKSAAD
       370        380        390
ARYEAACNRL ANKAVQRGSA DNVTVMVVRI GH

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H0C8-1-Acetylation	MDLFGD...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H0C8-1-Acetylation	MDLFGD...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9H0C8-1-Acetylation	MDLFGD...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9H0C8-1-Acetylation	MDLFGD...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9H0C8-28-unknown	LFDDLP...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14989
Q9H0C8-40-	SGSGGP...	40			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H0C8-184-unknown	EKTVKR...	184		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000406254

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QKGPLL	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14989
...KPAWKD	214	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395301
...VRIGH	392	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	27	GPLL.\|.LFDD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)