Q9H0H5: Rac GTPase-activating protein 1

General Information

Protein names	- Rac GTPase-activating protein 1 - Male germ cell RacGap - MgcRacGAP - Protein CYK4 homolog - CYK4 - HsCYK-4
Gene names	RACGAP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H0H5

8 N-termini

17 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDTMMLNVRN LFEQLVRRVE ILSEGNEVQF IQLAKDFEDF RKKWQRTDHE LGKYKDLLMK
        70         80         90        100        110        120
AETERSALDV KLKHARNQVD VEIKRRQRAE ADCEKLERQI QLIREMLMCD TSGSIQLSEE
       130        140        150        160        170        180
QKSALAFLNR GQPSSSNAGN KRLSTIDESG SILSDISFDK TDESLDWDSS LVKTFKLKKR
       190        200        210        220        230        240
EKRRSTSRQF VDGPPGPVKK TRSIGSAVDQ GNESIVAKTT VTVPNDGGPI EAVSTIETVP
       250        260        270        280        290        300
YWTRSRRKTG TLQPWNSDST LNSRQLEPRT ETDSVGTPQS NGGMRLHDFV SKTVIKPESC
       310        320        330        340        350        360
VPCGKRIKFG KLSLKCRDCR VVSHPECRDR CPLPCIPTLI GTPVKIGEGM LADFVSQTSP
       370        380        390        400        410        420
MIPSIVVHCV NEIEQRGLTE TGLYRISGCD RTVKELKEKF LRVKTVPLLS KVDDIHAICS
       430        440        450        460        470        480
LLKDFLRNLK EPLLTFRLNR AFMEAAEITD EDNSIAAMYQ AVGELPQANR DTLAFLMIHL
       490        500        510        520        530        540
QRVAQSPHTK MDVANLAKVF GPTIVAHAVP NPDPVTMLQD IKRQPKVVER LLSLPLEYWS
       550        560        570        580        590        600
QFMMVEQENI DPLHVIENSN AFSTPQTPDI KVSLLGPVTT PEHQLLKTPS SSSLSQRVRS
       610        620        630
TLTKNTPRFG SKSKSATNLG RQGNFFASPM LK

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 17 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H0H5-1-Acetylation	MDTMML...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H0H5-1-Acetylation	MDTMML...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9H0H5-1-Acetylation	MDTMML...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9H0H5-59-unknown	MKAETE...	59		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449963
Q9H0H5-59-unknown	MKAETE...	59		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450064
Q9H0H5-59-unknown	MKAETE...	59		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448968
Q9H0H5-203-	SIGSAV...	203			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9H0H5-203-	SIGSAV...	203			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H0H5-203-	SIGSAV...	203			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9H0H5-210-unknown	QGNESI...	210		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449565
Q9H0H5-274-	SVGTPQ...	274			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9H0H5-274-	SVGTPQ...	274			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9H0H5-274-	SVGTPQ...	274			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H0H5-274-	SVGTPQ...	274			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9H0H5-274-	SVGTPQ...	274			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9H0H5-274-unknown	SVGTPQ...	274			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9H0H5-284-unknown	MRLHDF...	284		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448507
Q9H0H5-491-unknown	MDVANL...	491		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000446889

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IREMLM	107	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448136
...LMCDTS	111	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449959
...LAFLNR	129	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448707
...AFLNRG	130	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449186
...SSNAGN	139	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447177
...NAGNKR	141	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448968
...NAGNKR	141	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450074
...IDESGS	150	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447393
...SILSDI	155	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449669
...TDESLD	165	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449620
...SLVKTF	174	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449170
...KKREKR	182	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450064
...SAVDQG	210	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447429
...SAVDQG	210	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449963
...NDGGPI	229	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446642
...FVSKTV	293	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448697
...SLKCRD	317	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448507
...SQFMMV	544	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449565
...SPMLK	632	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)