Q9H6Q4: Cytosolic iron-sulfur assembly component 3 {ECO:0000305}

General Information

Protein names	- Cytosolic iron-sulfur assembly component 3 {ECO:0000305} - Cytosolic Fe-S cluster assembly factor NARFL - Iron-only hydrogenase-like protein 1 {ECO:0000303\|PubMed:16956324} - IOP1 {ECO:0000303\|PubMed:16956324} - Nuclear prelamin A recognition factor-like protein - Protein related to Narf
Gene names	NARFL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H6Q4

7 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cytosolic Fe-S cluster assembly factor NARFL - Isoform 3 of Cytosolic Fe-S cluster assembly factor NARFL - Isoform 2 of Cytosolic iron-sulfur assembly component 3 - Isoform 3 of Cytosolic iron-sulfur assembly component 3

Sequence View

        10         20         30         40         50         60
MASPFSGALQ LTDLDDFIGP SQECIKPVKV EKRAGSGVAK IRIEDDGSYF QINQDGGTRR
        70         80         90        100        110        120
LEKAKVSLND CLACSGCITS AETVLITQQS HEELKKVLDA NKMAAPSQQR LVVVSVSPQS
       130        140        150        160        170        180
RASLAARFQL NPTDTARKLT SFFKKIGVHF VFDTAFSRHF SLLESQREFV RRFRGQADCR
       190        200        210        220        230        240
QALPLLASAC PGWICYAEKT HGSFILPHIS TARSPQQVMG SLVKDFFAQQ QHLTPDKIYH
       250        260        270        280        290        300
VTVMPCYDKK LEASRPDFFN QEHQTRDVDC VLTTGEVFRL LEEEGVSLPD LEPAPLDSLC
       310        320        330        340        350        360
SGASAEEPTS HRGGGSGGYL EHVFRHAARE LFGIHVAEVT YKPLRNKDFQ EVTLEKEGQV
       370        380        390        400        410        420
LLHFAMAYGF RNIQNLVQRL KRGRCPYHYV EVMACPSGCL NGGGQLQAPD RPSRELLQHV
       430        440        450        460        470
ERLYGMVRAE APEDAPGVQE LYTHWLQGTD SECAGRLLHT QYHAVEKAST GLGIRW         10         20         30         40         50         60
MASPFSGALQ LTDLDDFIGP SQECIKPVKV EKRAGSGVAK IRIEDDGSYF QINQDGGTRR
        70         80         90        100        110        120
LEKAKVSLND CLACSGCITS AETVLITQQS HEELKKVLDA NKMAAPSQQR LVVVSVSPQS
       130        140        150        160        170        180
RASLAARFQL NPTDTARKLT SFFKKIGVHF VFDTAFSRHF SLLESQREFV RRFRGQADCR
       190        200        210        220        230        240
QALPLLASAC PGWICYAEKT HGSFILPHIS TARSPQQVMG SLVKDFFAQQ QHLTPDKIYH
       250        260        270        280        290        300
VTVMPCYDKK LEASRPDFFN QEHQTRDVDC VLTTGEVFRL LEEEGVSLPD LEPAPLDSLC
       310        320        330        340        350        360
SGASAEEPTS HRGGGSGGYL EHVFRHAARE LFGIHVAEVT YKPLRNKDFQ EVTLEKEGQV
       370        380        390        400        410        420
LLHFAMAYGF RNIQNLVQRL KRGRCPYHYV EVMACPSGCL NGGGQLQAPD RPSRELLQHV
       430        440        450        460        470
ERLYGMVRAE APEDAPGVQE LYTHWLQGTD SECAGRLLHT QYHAVEKAST GLGIRW         10         20         30         40         50         60
MASPFSGALQ LTDLDDFIGP SQECIKPVKV EKRAGSGVAK IRIEDDGSYF QINQDGGTRR
        70         80         90        100        110        120
LEKAKVSLND CLACSGCITS AETVLITQQS HEELKKVLDA NKMAAPSQQR LVVVSVSPQS
       130        140        150        160        170        180
RASLAARFQL NPTDTARKLT SFFKKIGVHF VFDTAFSRHF SLLESQREFV RRFRGQADCR
       190        200        210        220        230        240
QALPLLASAC PGWICYAEKT HGSFILPHIS TARSPQQVMG SLVKDFFAQQ QHLTPDKIYH
       250        260        270        280        290        300
VTVMPCYDKK LEASRPDFFN QEHQTRDVDC VLTTGEVFRL LEEEGVSLPD LEPAPLDSLC
       310        320        330        340        350        360
SGASAEEPTS HRGGGSGGYL EHVFRHAARE LFGIHVAEVT YKPLRNKDFQ EVTLEKEGQV
       370        380        390        400        410        420
LLHFAMAYGF RNIQNLVQRL KRGRCPYHYV EVMACPSGCL NGGGQLQAPD RPSRELLQHV
       430        440        450        460        470
ERLYGMVRAE APEDAPGVQE LYTHWLQGTD SECAGRLLHT QYHAVEKAST GLGIRW         10         20         30         40         50         60
MASPFSGALQ LTDLDDFIGP SQECIKPVKV EKRAGSGVAK IRIEDDGSYF QINQDGGTRR
        70         80         90        100        110        120
LEKAKVSLND CLACSGCITS AETVLITQQS HEELKKVLDA NKMAAPSQQR LVVVSVSPQS
       130        140        150        160        170        180
RASLAARFQL NPTDTARKLT SFFKKIGVHF VFDTAFSRHF SLLESQREFV RRFRGQADCR
       190        200        210        220        230        240
QALPLLASAC PGWICYAEKT HGSFILPHIS TARSPQQVMG SLVKDFFAQQ QHLTPDKIYH
       250        260        270        280        290        300
VTVMPCYDKK LEASRPDFFN QEHQTRDVDC VLTTGEVFRL LEEEGVSLPD LEPAPLDSLC
       310        320        330        340        350        360
SGASAEEPTS HRGGGSGGYL EHVFRHAARE LFGIHVAEVT YKPLRNKDFQ EVTLEKEGQV
       370        380        390        400        410        420
LLHFAMAYGF RNIQNLVQRL KRGRCPYHYV EVMACPSGCL NGGGQLQAPD RPSRELLQHV
       430        440        450        460        470
ERLYGMVRAE APEDAPGVQE LYTHWLQGTD SECAGRLLHT QYHAVEKAST GLGIRW

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q9H6Q4-2-unknown	MASPFS...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H6Q4-2-Acetylation	ASPFSG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H6Q4-47-unknown	GSYFQI...	47		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13316
Q9H6Q4-56-unknown	GGTRRL...	56		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13317
Q9H6Q4-103-unknown	MAAPSQ...	103		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82287
Q9H6Q4-244-unknown	MPCYDK...	244		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82286
Q9H6Q4-244-unknown	MPCYDK...	244		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102153
Q9H6Q4-301-unknown	SGASAE...	301		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8091
Q9H6Q4-301-unknown	SGASAE...	301		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139755
Q9H6Q4-301-unknown	SGASAE...	301		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146549

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RIEDDG	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13316
...QINQDG	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13317
...LDSLCS	300	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8091
...LDSLCS	300	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122854
...LDSLCS	300	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129856
...LGIRW	476	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LGIRW	476	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77904
...LGIRW	476	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77905

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	46	EDDG.\|.GSYF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	55	NQDG.\|.GGTR	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATS_HUMAN	300	SLCS.\|.SGAS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)