Q9H6S0: 3'-5' RNA helicase YTHDC2 {ECO:0000305}

General Information

Protein names	- 3'-5' RNA helicase YTHDC2 {ECO:0000305} - 3.6.4.13 {ECO:0000269\|PubMed:29033321} - YTH domain-containing protein 2 {ECO:0000303\|PubMed:29033321} - hYTHDC2 {ECO:0000303\|PubMed:29033321}
Gene names	YTHDC2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H6S0

3 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSRPSSVSPR QPAPGGGGGG GPSPCGPGGG GRAKGLKDIR IDEEVKIAVN IALERFRYGD
        70         80         90        100        110        120
QREMEFPSSL TSTERAFIHR LSQSLGLVSK SKGKGANRYL TVKKKDGSET AHAMMTCNLT
       130        140        150        160        170        180
HNTKHAVRSL IQRFPVTNKE RTELLPKTER GNVFAVEAEN REMSKTSGRL NNGIPQIPVK
       190        200        210        220        230        240
RGESEFDSFR QSLPVFEKQE EIVKIIKENK VVLIVGETGS GKTTQIPQFL LDDCFKNGIP
       250        260        270        280        290        300
CRIFCTQPRR LAAIAVAERV AAERRERIGQ TIGYQIRLES RVSPKTLLTF CTNGVLLRTL
       310        320        330        340        350        360
MAGDSTLSTV THVIVDEVHE RDRFSDFLLT KLRDLLQKHP TLKLILSSAA LDVNLFIRYF
       370        380        390        400        410        420
GSCPVIYIQG RPFEVKEMFL EDILRTTGYT NKEMLKYKKE KQQEEKQQTT LTEWYSAQEN
       430        440        450        460        470        480
SFKPESQRQR TVLNVTDEYD LLDDGGDAVF SQLTEKDVNC LEPWLIKEMD ACLSDIWLHK
       490        500        510        520        530        540
DIDAFAQVFH LILTENVSVD YRHSETSATA LMVAAGRGFA SQVEQLISMG ANVHSKASNG
       550        560        570        580        590        600
WMALDWAKHF GQTEIVDLLE SYSATLEFGN LDESSLVQTN GSDLSAEDRE LLKAYHHSFD
       610        620        630        640        650        660
DEKVDLDLIM HLLYNICHSC DAGAVLIFLP GYDEIVGLRD RILFDDKRFA DSTHRYQVFM
       670        680        690        700        710        720
LHSNMQTSDQ KKVLKNPPAG VRKIILSTNI AETSITVNDV VFVIDSGKVK EKSFDALNFV
       730        740        750        760        770        780
TMLKMVWISK ASAIQRKGRA GRCRPGICFR LFSRLRFQNM LEFQTPELLR MPLQELCLHT
       790        800        810        820        830        840
KLLAPVNCPI ADFLMKAPEP PPALIVRNAV QMLKTIDAMD TWEDLTELGY HLADLPVEPH
       850        860        870        880        890        900
LGKMVLCAVV LKCLDPILTI ACTLAYRDPF VLPTQASQKR AAMLCRKRFT AGAFSDHMAL
       910        920        930        940        950        960
LRAFQAWQKA RSDGWERAFC EKNFLSQATM EIIIGMRTQL LGQLRASGFV RARGGGDIRD
       970        980        990       1000       1010       1020
VNTNSENWAV VKAALVAGMY PNLVHVDREN LVLTGPKEKK VRFHPASVLS QPQYKKIPPA
      1030       1040       1050       1060       1070       1080
NGQAAAIKAL PTDWLIYDEM TRAHRIANIR CCSAVTPVTI LVFCGPARLA SNALQEPSSF
      1090       1100       1110       1120       1130       1140
RVDGIPNDSS DSEMEDKTTA NLAALKLDEW LHFTLEPEAA SLLLQLRQKW HSLFLRRMRA
      1150       1160       1170       1180       1190       1200
PSKPWSQVDE ATIRAIIAVL STEEQSAGLQ QPSGIGQRPR PMSSEELPLA SSWRSNNSRK
      1210       1220       1230       1240       1250       1260
SSADTEFSDE CTTAERVLMK SPSPALHPPQ KYKDRGILHP KRGTEDRSDQ SSLKSTDSSS
      1270       1280       1290       1300       1310       1320
YPSPCASPSP PSSGKGSKSP SPRPNMPVRY FIMKSSNLRN LEISQQKGIW STTPSNERKL
      1330       1340       1350       1360       1370       1380
NRAFWESSIV YLVFSVQGSG HFQGFSRMSS EIGREKSQDW GSAGLGGVFK VEWIRKESLP
      1390       1400       1410       1420       1430
FQFAHHLLNP WNDNKKVQIS RDGQELEPLV GEQLLQLWER LPLGEKNTTD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H6S0-1-unknown	MSRPSS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H6S0-1084-	GIPNDS...	1084		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9H6S0-1084-	GIPNDS...	1084		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9H6S0-1084-	GIPNDS...	1084		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9H6S0-1084-	GIPNDS...	1084		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9H6S0-1258-unknown	SSSYPS...	1258	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13318

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LPVFEK	197	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000422916
...TSDQKK	671		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QRKGRA	739	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000423101
...LKSTDS	1257	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13318
...KNTTD	1430	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	1257	STDS.\|.SSSY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)