Q9H7B2: Ribosome production factor 2 homolog

General Information

Protein names	- Ribosome production factor 2 homolog - Brix domain-containing protein 1 - Ribosome biogenesis protein RPF2 homolog
Gene names	RPF2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H7B2

6 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDTLDRVVKP KTKRAKRFLE KREPKLNENI KNAMLIKGGN ANATVTKVLK DVYALKKPYG
        70         80         90        100        110        120
VLYKKKNITR PFEDQTSLEF FSKKSDCSLF MFGSHNKKRP NNLVIGRMYD YHVLDMIELG
       130        140        150        160        170        180
IENFVSLKDI KNSKCPEGTK PMLIFAGDDF DVTEDYRRLK SLLIDFFRGP TVSNIRLAGL
       190        200        210        220        230        240
EYVLHFTALN GKIYFRSYKL LLKKSGCRTP RIELEEMGPS LDLVLRRTHL ASDDLYKLSM
       250        260        270        280        290        300
KMPKALKPKK KKNISHDTFG TTYGRIHMQK QDLSKLQTRK MKGLKKRPAE RITEDHEKKS

KRIKKN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H7B2-1-unknown	MDTLDR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H7B2-1-acetylation	MDTLDR...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9H7B2-1-acetylation	MDTLDR...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9H7B2-7-unknown	VVKPKT...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10556
Q9H7B2-34-unknown	MLIKGG...	34		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000414026
Q9H7B2-67-	NITRPF...	67			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9H7B2-286-unknown	KRPAER...	286		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13322

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DTLDRV	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10556
...PKALKP	247	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414026
...MKGLKK	285	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13322
...RIKKN	306	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	6	LDRV.\|.VVKP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	285	GLKK.\|.KRPA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)