Q9H7N4: Splicing factor, arginine/serine-rich 19

General Information

Protein names	- Splicing factor, arginine/serine-rich 19 - SR-related C-terminal domain-associated factor 1 - SR-related and CTD-associated factor 1 - SR-related-CTD-associated factor - SCAF - Serine arginine-rich pre-mRNA splicing factor SR-A1 - SR-A1
Gene names	SCAF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H7N4

3 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEEEDESRGK TEESGEDRGD GPPDRDPTLS PSAFILRAIQ QAVGSSLQGD LPNDKDGSRC
        70         80         90        100        110        120
HGLRWRRCRS PRSEPRSQES GGTDTATVLD MATDSFLAGL VSVLDPPDTW VPSRLDLRPG
       130        140        150        160        170        180
ESEDMLELVA EVRIGDRDPI PLPVPSLLPR LRAWRTGKTV SPQSNSSRPT CARHLTLGTG
       190        200        210        220        230        240
DGGPAPPPAP SSASSSPSPS PSSSSPSPPP PPPPPAPPAP PAPRFDIYDP FHPTDEAYSP
       250        260        270        280        290        300
PPAPEQKYDP FEPTGSNPSS SAGTPSPEEE EEEEEEEEEE EEDEEEEEGL SQSISRISET
       310        320        330        340        350        360
LAGIYDDNSL SQDFPGDESP RPDAQPTQPT PAPGTPPQVD STRADGAMRR RVFVVGTEAE
       370        380        390        400        410        420
ACREGKVSVE VVTAGGAALP PPLLPPGDSE IEEGEIVQPE EEPRLALSLF RPGGRAARPT
       430        440        450        460        470        480
PAASATPTAQ PLPQPPAPRA PEGDDFLSLH AESDGEGALQ VDLGEPAPAP PAADSRWGGL
       490        500        510        520        530        540
DLRRKILTQR RERYRQRSPS PAPAPAPAAA AGPPTRKKSR RERKRSGEAK EAASSSSGTQ
       550        560        570        580        590        600
PAPPAPASPW DSKKHRSRDR KPGSHASSSA RRRSRSRSRS RSTRRRSRST DRRRGGSRRS
       610        620        630        640        650        660
RSREKRRRRR RSASPPPATS SSSSSRRERH RGKHRDGGGS KKKKKRSRSR GEKRSGDGSE
       670        680        690        700        710        720
KAPAPAPPPS GSTSCGDRDS RRRGAVPPSI QDLTDHDLFA IKRTITVGRL DKSDPRGPSP
       730        740        750        760        770        780
APASSPKREV LYDSEGLSGE ERGGKSSQKD RRRSGAASSS SSSREKGSRR KALDGGDRDR
       790        800        810        820        830        840
DRDRDRDRDR SSKKARPPKE SAPSSGPPPK PPVSSGSGSS SSSSSCSSRK VKLQSKVAVL
       850        860        870        880        890        900
IREGVSSTTP AKDAASAGLG SIGVKFSRDR ESRSPFLKPD ERAPTEMAKA APGSTKPKKT
       910        920        930        940        950        960
KVKAKAGAKK TKGTKGKTKP SKTRKKVRSG GGSGGSGGQV SLKKSKADSC SQAAGTKGAE
       970        980        990       1000       1010       1020
ETSWSGEERA AKVPSTPPPK AAPPPPALTP DSQTVDSSCK TPEVSFLPEE ATEEAGVRGG
      1030       1040       1050       1060       1070       1080
AEEEEEEEEE EEEEEEEEEQ QPATTTATST AAAAPSTAPS AGSTAGDSGA EDGPASRVSQ
      1090       1100       1110       1120       1130       1140
LPTLPPPMPW NLPAGVDCTT SGVLALTALL FKMEEANLAS RAKAQELIQA TNQILSHRKP
      1150       1160       1170       1180       1190       1200
PSSLGMTPAP VPTSLGLPPG PSSYLLPGSL PLGGCGSTPP TPTGLAATSD KREGSSSSEG
      1210       1220       1230       1240       1250       1260
RGDTDKYLKK LHTQERAVEE VKLAIKPYYQ KKDITKEEYK DILRKAVHKI CHSKSGEINP
      1270       1280       1290       1300       1310
VKVSNLVRAY VQRYRYFRKH GRKPGDPPGP PRPPKEPGPP DKGGPGLPLP PL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H7N4-1-unknown	MEEEDE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H7N4-463-unknown	LGEPAP...	463	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13324
Q9H7N4-464-	GEPAPA...	464		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9H7N4-464-	GEPAPA...	464		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9H7N4-464-	GEPAPA...	464		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DSFLAG	98	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472649
...PSPSSS	203	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000473210
...ALQVDL	462	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13324
...PLPPL	1312	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	462	QVDL.\|.LGEP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)