Q9H875: PRKR-interacting protein 1

General Information

Protein names	- PRKR-interacting protein 1
Gene names	PRKRIP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H875

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASPAASSVR PPRPKKEPQT LVIPKNAAEE QKLKLERLMK NPDKAVPIPE KMSEWAPRPP
        70         80         90        100        110        120
PEFVRDVMGS SAGAGSGEFH VYRHLRRREY QRQDYMDAMA EKQKLDAEFQ KRLEKNKIAA
       130        140        150        160        170        180
EEQTAKRRKK RQKLKEKKLL AKKMKLEQKK QEGPGQPKEQ GSSSSAEASG TEEEEEVPSF

TMGR

Isoforms

- Isoform 2 of PRKR-interacting protein 1

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H875-1-unknown	MASPAA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H875-39-unknown	MKNPDK...	39	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000346837
Q9H875-98-	AMAEKQ...	98		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9H875-98-	AMAEKQ...	98		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H875-98-	AMAEKQ...	98		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9H875-98-unknown	AMAEKQ...	98	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2325
Q9H875-106-unknown	DAEFQK...	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15004

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QDYMDA	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2325
...EKQKLD	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15004
...FTMGR	184	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	97	YMDA.\|.AMAE	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> PKRI1_HUMAN @97
GRAM_HUMAN	105	QKLD.\|.DAEF	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)