Q9H8H2: Probable ATP-dependent RNA helicase DDX31

General Information

Protein names	- Probable ATP-dependent RNA helicase DDX31 - 3.6.4.13 - DEAD box protein 31 - Helicain
Gene names	DDX31
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H8H2

7 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Probable ATP-dependent RNA helicase DDX31 - Isoform 3 of Probable ATP-dependent RNA helicase DDX31 - Isoform 4 of Probable ATP-dependent RNA helicase DDX31

Sequence View

        10         20         30         40         50         60
MAPDLASQRH SESFPSVNSR PNVILPGREG RREGLPPGGG TRGSLVPTRP VPPSPAPLGT
        70         80         90        100        110        120
SPYSWSRSGP GRGGGAGSSR VPRGVPGPAV CAPGSLLHHA SPTQTMAAAD GSLFDNPRTF
       130        140        150        160        170        180
SRRPPAQASR QAKATKRKYQ ASSEAPPAKR RNETSFLPAK KTSVKETQRT FKGNAQKMFS
       190        200        210        220        230        240
PKKHSVSTSD RNQEERQCIK TSSLFKNNPD IPELHRPVVK QVQEKVFTSA AFHELGLHPH
       250        260        270        280        290        300
LISTINTVLK MSSMTSVQKQ SIPVLLEGRD ALVRSQTGSG KTLAYCIPVV QSLQAMESKI
       310        320        330        340        350        360
QRSDGPYALV LVPTRELALQ SFDTVQKLLK PFTWIVPGVL MGGEKRKSEK ARLRKGINIL
       370        380        390        400        410        420
ISTPGRLVDH IKSTKNIHFS RLRWLVFDEA DRILDLGFEK DITVILNAVN AECQKRQNVL
       430        440        450        460        470        480
LSATLTEGVT RLADISLHDP VSISVLDKSH DQLNPKDKAV QEVCPPPAGD KLDSFAIPES
       490        500        510        520        530        540
LKQHVTVVPS KLRLVCLAAF ILQKCKFEED QKMVVFFSSC ELVEFHYSLF LQTLLSSSGA
       550        560        570        580        590        600
PASGQLPSAS MRLKFLRLHG GMEQEERTAV FQEFSHSRRG VLLCTDVAAR GLDLPQVTWI
       610        620        630        640        650        660
VQYNAPSSPA EYIHRIGRTA RIGCHGSSLL ILAPSEAEYV NSLASHKINV SEIKMEDILC
       670        680        690        700        710        720
VLTRDDCFKG KRWGAQKSHA VGPQEIRERA TVLQTVFEDY VHSSERRVSW AKKALQSFIQ
       730        740        750        760        770        780
AYATYPRELK HIFHVRSLHL GHVAKSFGLR DAPRNLSALT RKKRKAHVKR PDLHKKTQSK
       790        800        810        820        830        840
HSLAEILRSE YSSGMEADIA KVKKQNAPGE PGGRPLQHSL QPTPCFGRGK TLKWRKTQKG
       850
VQRDSKTSQK V         10         20         30         40         50         60
MAPDLASQRH SESFPSVNSR PNVILPGREG RREGLPPGGG TRGSLVPTRP VPPSPAPLGT
        70         80         90        100        110        120
SPYSWSRSGP GRGGGAGSSR VPRGVPGPAV CAPGSLLHHA SPTQTMAAAD GSLFDNPRTF
       130        140        150        160        170        180
SRRPPAQASR QAKATKRKYQ ASSEAPPAKR RNETSFLPAK KTSVKETQRT FKGNAQKMFS
       190        200        210        220        230        240
PKKHSVSTSD RNQEERQCIK TSSLFKNNPD IPELHRPVVK QVQEKVFTSA AFHELGLHPH
       250        260        270        280        290        300
LISTINTVLK MSSMTSVQKQ SIPVLLEGRD ALVRSQTGSG KTLAYCIPVV QSLQAMESKI
       310        320        330        340        350        360
QRSDGPYALV LVPTRELALQ SFDTVQKLLK PFTWIVPGVL MGGEKRKSEK ARLRKGINIL
       370        380        390        400        410        420
ISTPGRLVDH IKSTKNIHFS RLRWLVFDEA DRILDLGFEK DITVILNAVN AECQKRQNVL
       430        440        450        460        470        480
LSATLTEGVT RLADISLHDP VSISVLDKSH DQLNPKDKAV QEVCPPPAGD KLDSFAIPES
       490        500        510        520        530        540
LKQHVTVVPS KLRLVCLAAF ILQKCKFEED QKMVVFFSSC ELVEFHYSLF LQTLLSSSGA
       550        560        570        580        590        600
PASGQLPSAS MRLKFLRLHG GMEQEERTAV FQEFSHSRRG VLLCTDVAAR GLDLPQVTWI
       610        620        630        640        650        660
VQYNAPSSPA EYIHRIGRTA RIGCHGSSLL ILAPSEAEYV NSLASHKINV SEIKMEDILC
       670        680        690        700        710        720
VLTRDDCFKG KRWGAQKSHA VGPQEIRERA TVLQTVFEDY VHSSERRVSW AKKALQSFIQ
       730        740        750        760        770        780
AYATYPRELK HIFHVRSLHL GHVAKSFGLR DAPRNLSALT RKKRKAHVKR PDLHKKTQSK
       790        800        810        820        830        840
HSLAEILRSE YSSGMEADIA KVKKQNAPGE PGGRPLQHSL QPTPCFGRGK TLKWRKTQKG
       850
VQRDSKTSQK V         10         20         30         40         50         60
MAPDLASQRH SESFPSVNSR PNVILPGREG RREGLPPGGG TRGSLVPTRP VPPSPAPLGT
        70         80         90        100        110        120
SPYSWSRSGP GRGGGAGSSR VPRGVPGPAV CAPGSLLHHA SPTQTMAAAD GSLFDNPRTF
       130        140        150        160        170        180
SRRPPAQASR QAKATKRKYQ ASSEAPPAKR RNETSFLPAK KTSVKETQRT FKGNAQKMFS
       190        200        210        220        230        240
PKKHSVSTSD RNQEERQCIK TSSLFKNNPD IPELHRPVVK QVQEKVFTSA AFHELGLHPH
       250        260        270        280        290        300
LISTINTVLK MSSMTSVQKQ SIPVLLEGRD ALVRSQTGSG KTLAYCIPVV QSLQAMESKI
       310        320        330        340        350        360
QRSDGPYALV LVPTRELALQ SFDTVQKLLK PFTWIVPGVL MGGEKRKSEK ARLRKGINIL
       370        380        390        400        410        420
ISTPGRLVDH IKSTKNIHFS RLRWLVFDEA DRILDLGFEK DITVILNAVN AECQKRQNVL
       430        440        450        460        470        480
LSATLTEGVT RLADISLHDP VSISVLDKSH DQLNPKDKAV QEVCPPPAGD KLDSFAIPES
       490        500        510        520        530        540
LKQHVTVVPS KLRLVCLAAF ILQKCKFEED QKMVVFFSSC ELVEFHYSLF LQTLLSSSGA
       550        560        570        580        590        600
PASGQLPSAS MRLKFLRLHG GMEQEERTAV FQEFSHSRRG VLLCTDVAAR GLDLPQVTWI
       610        620        630        640        650        660
VQYNAPSSPA EYIHRIGRTA RIGCHGSSLL ILAPSEAEYV NSLASHKINV SEIKMEDILC
       670        680        690        700        710        720
VLTRDDCFKG KRWGAQKSHA VGPQEIRERA TVLQTVFEDY VHSSERRVSW AKKALQSFIQ
       730        740        750        760        770        780
AYATYPRELK HIFHVRSLHL GHVAKSFGLR DAPRNLSALT RKKRKAHVKR PDLHKKTQSK
       790        800        810        820        830        840
HSLAEILRSE YSSGMEADIA KVKKQNAPGE PGGRPLQHSL QPTPCFGRGK TLKWRKTQKG
       850
VQRDSKTSQK V

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H8H2-1-unknown	MAPDLA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H8H2-1-unknown	MAPDLA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72541
Q9H8H2-1-unknown	MAPDLA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72542
Q9H8H2-1-unknown	MAPDLA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72543
Q9H8H2-107-acetylation	AAADGS...	107	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9H8H2-107-acetylation	AAADGS...	107	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163374
Q9H8H2-107-acetylation	AAADGS...	107	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163375
Q9H8H2-107-acetylation	AAADGS...	107	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163376
Q9H8H2-107-	AAADGS...	107			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9H8H2-107-	AAADGS...	107			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H8H2-107-unknown	AAADGS...	107		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169864
Q9H8H2-107-unknown	AAADGS...	107		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169865
Q9H8H2-107-unknown	AAADGS...	107		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169866
Q9H8H2-474-	SFAIPE...	474			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9H8H2-474-unknown	SFAIPE...	474		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176397
Q9H8H2-474-unknown	SFAIPE...	474		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176398
Q9H8H2-799-unknown	IAKVKK...	799		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13338
Q9H8H2-799-unknown	IAKVKK...	799		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156107

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...VLLCTD	585	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt68161
...VLLCTD	585	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt93095
...GMEADI	798	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13338
...GMEADI	798	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt139570
...TSQKV	851		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TSQKV	851	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...TSQKV	851	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt68159
...TSQKV	851		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	798	EADI.\|.IAKV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)