Q9HCE5: N6-adenosine-methyltransferase non-catalytic subunit {ECO:0000305}

General Information

Protein names	- N6-adenosine-methyltransferase non-catalytic subunit {ECO:0000305} - Methyltransferase-like protein 14 {ECO:0000312\|HGNC:HGNC:29330} - hMETTL14 {ECO:0000303\|PubMed:27373337}
Gene names	METTL14
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9HCE5

7 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDSRLQEIRE RQKLRRQLLA QQLGAESADS IGAVLNSKDE QREIAETRET CRASYDTSAP
        70         80         90        100        110        120
NAKRKYLDEG ETDEDKMEEY KDELEMQQDE ENLPYEEEIY KDSSTFLKGT QSLNPHNDYC
       130        140        150        160        170        180
QHFVDTGHRP QNFIRDVGLA DRFEEYPKLR ELIRLKDELI AKSNTPPMYL QADIEAFDIR
       190        200        210        220        230        240
ELTPKFDVIL LEPPLEEYYR ETGITANEKC WTWDDIMKLE IDEIAAPRSF IFLWCGSGEG
       250        260        270        280        290        300
LDLGRVCLRK WGYRRCEDIC WIKTNKNNPG KTKTLDPKAV FQRTKEHCLM GIKGTVKRST
       310        320        330        340        350        360
DGDFIHANVD IDLIITEEPE IGNIEKPVEI FHIIEHFCLG RRRLHLFGRD STIRPGWLTV
       370        380        390        400        410        420
GPTLTNSNYN AETYASYFSA PNSYLTGCTE EIERLRPKSP PPKSKSDRGG GAPRGGGRGG
       430        440        450
TSAGRGRERN RSNFRGERGG FRGGRGGAHR GGFPPR

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9HCE5-1-unknown	MDSRLQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9HCE5-30-	SIGAVL...	30		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9HCE5-30-	SIGAVL...	30		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9HCE5-30-	SIGAVL...	30		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9HCE5-30-	SIGAVL...	30		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9HCE5-30-	SIGAVL...	30		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9HCE5-30-	SIGAVL...	30		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9HCE5-30-	SIGAVL...	30		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9HCE5-30-unknown	SIGAVL...	30		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9HCE5-33-	AVLNSK...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9HCE5-33-unknown	AVLNSK...	33		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9HCE5-53-	ASYDTS...	53		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9HCE5-53-	ASYDTS...	53		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9HCE5-109-	GTQSLN...	109		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LDEGET	71	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000425460
	...GFPPR	456	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)