Q9NQZ2: Something about silencing protein 10

General Information

Protein names	- Something about silencing protein 10 - Charged amino acid-rich leucine zipper 1 - CRL1 - Disrupter of silencing SAS10 - UTP3 homolog
Gene names	UTP3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NQZ2

4 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVGRSRRRGA AKWAAVRAKA GPTLTDENGD DLGLPPSPGD TSYYQDQVDD FHEARSRAAL
        70         80         90        100        110        120
AKGWNEVQSG DEEDGEEEEE EVLALDMDDE DDEDGGNAGE EEEEENADDD GGSSVQSEAE
       130        140        150        160        170        180
ASVDPSLSWG QRKKLYYDTD YGSKSRGRQS QQEAEEEERE EEEEAQIIQR RLAQALQEDD
       190        200        210        220        230        240
FGVAWVEAFA KPVPQVDEAE TRVVKDLAKV SVKEKLKMLR KESPELLELI EDLKVKLTEV
       250        260        270        280        290        300
KDELEPLLEL VEQGIIPPGK GSQYLRTKYN LYLNYCSNIS FYLILKARRV PAHGHPVIER
       310        320        330        340        350        360
LVTYRNLINK LSVVDQKLSS EIRHLLTLKD DAVKKELIPK AKSTKPKPKS VSKTSAAACA
       370        380        390        400        410        420
VTDLSDDSDF DEKAKLKYYK EIEDRQKLKR KKEENSTEEQ ALEDQNAKRA ITYQIAKNRG
       430        440        450        460        470
LTPRRKKIDR NPRVKHREKF RRAKIRRRGQ VREVRKEEQR YSGELSGIRA GVKKSIKLK

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NQZ2-1-unknown	MVGRSR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NQZ2-141-unknown	YGSKSR...	141	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13385
Q9NQZ2-360-	AVTDLS...	360		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NQZ2-396-unknown	STEEQA...	396	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15020

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...YYDTDY	140	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13385
...KKEENS	395	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15020
...SIKLK	479	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SIKLK	479		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SIKLK	479		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...SIKLK	479		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SIKLK	479		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	140	DTDY.\|.YGSK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	395	EENS.\|.STEE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)