Q9NR28: Diablo homolog, mitochondrial

General Information

Protein names	- Diablo homolog, mitochondrial - Direct IAP-binding protein with low pI - Second mitochondria-derived activator of caspase - Smac
Gene names	DIABLO
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NR28

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Diablo homolog, mitochondrial - Isoform 3 of Diablo homolog, mitochondrial

Sequence View

        10         20         30         40         50         60
MAALKSWLSR SVTSFFRYRQ CLCVPVVANF KKRCFSELIR PWHKTVTIGF GVTLCAVPIA
        70         80         90        100        110        120
QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL
       130        140        150        160        170        180
LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS
       190        200        210        220        230
ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED         10         20         30         40         50         60
MAALKSWLSR SVTSFFRYRQ CLCVPVVANF KKRCFSELIR PWHKTVTIGF GVTLCAVPIA
        70         80         90        100        110        120
QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL
       130        140        150        160        170        180
LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS
       190        200        210        220        230
ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NR28-1-unknown	MAALKS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72376
Q9NR28-56-unknown	AVPIAQ...	56	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NR28-56-unknown	AVPIAQ...	56		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NR28-56-unknown	AVPIAQ...	56		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NR28-56-	AVPIAQ...	56		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NR28-56-	AVPIAQ...	56		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9NR28-56-	AVPIAQ...	56		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NR28-56-	AVPIAQ...	56		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NR28-56-	AVPIAQ...	56		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9NR28-56-	AVPIAQ...	56		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9NR28-56-	AVPIAQ...	56		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9NR28-56-	AVPIAQ...	56		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YLRED	239	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YLRED	239	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67993
...YLRED	239	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67994

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)