Q9NRX4: 14 kDa phosphohistidine phosphatase {ECO:0000303|PubMed:12383260}

General Information

Protein names	- 14 kDa phosphohistidine phosphatase {ECO:0000303\|PubMed:12383260} - 3.9.1.3 {ECO:0000269\|PubMed:19836471, ECO:0000269\|PubMed:25574816} - Phosphohistidine phosphatase 1 {ECO:0000303\|PubMed:25574816} - PHPT1 {ECO:0000303\|PubMed:25574816} - Protein histidine phosphatase {ECO:0000303\|PubMed:19836471} - PHP {ECO:0000303\|PubMed:19836471} - Protein janus-A homolog
Gene names	PHPT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NRX4

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAVADLALIP DVDIDSDGVF KYVLIRVHSA PRSGAPAAES KEIVRGYKWA EYHADIYDKV
        70         80         90        100        110        120
SGDMQKQGCD CECLGGGRIS HQSQDKKIHV YGYSMAYGPA QHAISTEKIK AKYPDYEVTW

ANDGY

Isoforms

- Isoform 2 of 14 kDa phosphohistidine phosphatase

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
Q9NRX4-2-unknown	MAVADL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NRX4-1-unknown	MAVADL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85101
Q9NRX4-2-Acetylation	AVADLA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NRX4-2-Acetylation	AVADLA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9NRX4-2-Acetylation	AVADLA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110654
Q9NRX4-64-unknown	MQKQGC...	64		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13398
Q9NRX4-64-unknown	MQKQGC...	64		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140229
Q9NRX4-96-unknown	AYGPAQ...	96		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4259

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KVSGDM	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13398
...KVSGDM	63	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123346
...YGYSMA	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4259
...YGYSMA	95	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154313
...ANDGY	125	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	63	SGDM.\|.MQKQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATB_HUMAN	95	YSMA.\|.AYGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)