Q9NTJ3: Structural maintenance of chromosomes protein 4

General Information

Protein names	- Structural maintenance of chromosomes protein 4 - SMC protein 4 - SMC-4 - Chromosome-associated polypeptide C - hCAP-C - XCAP-C homolog
Gene names	SMC4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NTJ3

8 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPRKGTQPST ARRREEGPPP PSPDGASSDA EPEPPSGRTE SPATAAETAS EELDNRSLEE
        70         80         90        100        110        120
ILNSIPPPPP PAMTNEAGAP RLMITHIVNQ NFKSYAGEKI LGPFHKRFSC IIGPNGSGKS
       130        140        150        160        170        180
NVIDSMLFVF GYRAQKIRSK KLSVLIHNSD EHKDIQSCTV EVHFQKIIDK EGDDYEVIPN
       190        200        210        220        230        240
SNFYVSRTAC RDNTSVYHIS GKKKTFKDVG NLLRSHGIDL DHNRFLILQG EVEQIAMMKP
       250        260        270        280        290        300
KGQTEHDEGM LEYLEDIIGC GRLNEPIKVL CRRVEILNEH RGEKLNRVKM VEKEKDALEG
       310        320        330        340        350        360
EKNIAIEFLT LENEIFRKKN HVCQYYIYEL QKRIAEMETQ KEKIHEDTKE INEKSNILSN
       370        380        390        400        410        420
EMKAKNKDVK DTEKKLNKIT KFIEENKEKF TQLDLEDVQV REKLKHATSK AKKLEKQLQK
       430        440        450        460        470        480
DKEKVEEFKS IPAKSNNIIN ETTTRNNALE KEKEKEEKKL KEVMDSLKQE TQGLQKEKES
       490        500        510        520        530        540
REKELMGFSK SVNEARSKMD VAQSELDIYL SRHNTAVSQL TKAKEALIAA SETLKERKAA
       550        560        570        580        590        600
IRDIEGKLPQ TEQELKEKEK ELQKLTQEET NFKSLVHDLF QKVEEAKSSL AMNRSRGKVL
       610        620        630        640        650        660
DAIIQEKKSG RIPGIYGRLG DLGAIDEKYD VAISSCCHAL DYIVVDSIDI AQECVNFLKR
       670        680        690        700        710        720
QNIGVATFIG LDKMAVWAKK MTEIQTPENT PRLFDLVKVK DEKIRQAFYF ALRDTLVADN
       730        740        750        760        770        780
LDQATRVAYQ KDRRWRVVTL QGQIIEQSGT MTGGGSKVMK GRMGSSLVIE ISEEEVNKME
       790        800        810        820        830        840
SQLQNDSKKA MQIQEQKVQL EERVVKLRHS EREMRNTLEK FTASIQRLIE QEEYLNVQVK
       850        860        870        880        890        900
ELEANVLATA PDKKKQKLLE ENVSAFKTEY DAVAEKAGKV EAEVKRLHNT IVEINNHKLK
       910        920        930        940        950        960
AQQDKLDKIN KQLDECASAI TKAQVAIKTA DRNLQKAQDS VLRTEKEIKD TEKEVDDLTA
       970        980        990       1000       1010       1020
ELKSLEDKAA EVVKNTNAAE ESLPEIQKEH RNLLQELKVI QENEHALQKD ALSIKLKLEQ
      1030       1040       1050       1060       1070       1080
IDGHIAEHNS KIKYWHKEIS KISLHPIEDN PIEEISVLSP EDLEAIKNPD SITNQIALLE
      1090       1100       1110       1120       1130       1140
ARCHEMKPNL GAIAEYKKKE ELYLQRVAEL DKITYERDSF RQAYEDLRKQ RLNEFMAGFY
      1150       1160       1170       1180       1190       1200
IITNKLKENY QMLTLGGDAE LELVDSLDPF SEGIMFSVRP PKKSWKKIFN LSGGEKTLSS
      1210       1220       1230       1240       1250       1260
LALVFALHHY KPTPLYFMDE IDAALDFKNV SIVAFYIYEQ TKNAQFIIIS LRNNMFEISD
      1270       1280
RLIGIYKTYN ITKSVAVNPK EIASKGLC

Isoforms

- Isoform 2 of Structural maintenance of chromosomes protein 4

Sequence View

        10         20         30         40         50         60
MPRKGTQPST ARRREEGPPP PSPDGASSDA EPEPPSGRTE SPATAAETAS EELDNRSLEE
        70         80         90        100        110        120
ILNSIPPPPP PAMTNEAGAP RLMITHIVNQ NFKSYAGEKI LGPFHKRFSC IIGPNGSGKS
       130        140        150        160        170        180
NVIDSMLFVF GYRAQKIRSK KLSVLIHNSD EHKDIQSCTV EVHFQKIIDK EGDDYEVIPN
       190        200        210        220        230        240
SNFYVSRTAC RDNTSVYHIS GKKKTFKDVG NLLRSHGIDL DHNRFLILQG EVEQIAMMKP
       250        260        270        280        290        300
KGQTEHDEGM LEYLEDIIGC GRLNEPIKVL CRRVEILNEH RGEKLNRVKM VEKEKDALEG
       310        320        330        340        350        360
EKNIAIEFLT LENEIFRKKN HVCQYYIYEL QKRIAEMETQ KEKIHEDTKE INEKSNILSN
       370        380        390        400        410        420
EMKAKNKDVK DTEKKLNKIT KFIEENKEKF TQLDLEDVQV REKLKHATSK AKKLEKQLQK
       430        440        450        460        470        480
DKEKVEEFKS IPAKSNNIIN ETTTRNNALE KEKEKEEKKL KEVMDSLKQE TQGLQKEKES
       490        500        510        520        530        540
REKELMGFSK SVNEARSKMD VAQSELDIYL SRHNTAVSQL TKAKEALIAA SETLKERKAA
       550        560        570        580        590        600
IRDIEGKLPQ TEQELKEKEK ELQKLTQEET NFKSLVHDLF QKVEEAKSSL AMNRSRGKVL
       610        620        630        640        650        660
DAIIQEKKSG RIPGIYGRLG DLGAIDEKYD VAISSCCHAL DYIVVDSIDI AQECVNFLKR
       670        680        690        700        710        720
QNIGVATFIG LDKMAVWAKK MTEIQTPENT PRLFDLVKVK DEKIRQAFYF ALRDTLVADN
       730        740        750        760        770        780
LDQATRVAYQ KDRRWRVVTL QGQIIEQSGT MTGGGSKVMK GRMGSSLVIE ISEEEVNKME
       790        800        810        820        830        840
SQLQNDSKKA MQIQEQKVQL EERVVKLRHS EREMRNTLEK FTASIQRLIE QEEYLNVQVK
       850        860        870        880        890        900
ELEANVLATA PDKKKQKLLE ENVSAFKTEY DAVAEKAGKV EAEVKRLHNT IVEINNHKLK
       910        920        930        940        950        960
AQQDKLDKIN KQLDECASAI TKAQVAIKTA DRNLQKAQDS VLRTEKEIKD TEKEVDDLTA
       970        980        990       1000       1010       1020
ELKSLEDKAA EVVKNTNAAE ESLPEIQKEH RNLLQELKVI QENEHALQKD ALSIKLKLEQ
      1030       1040       1050       1060       1070       1080
IDGHIAEHNS KIKYWHKEIS KISLHPIEDN PIEEISVLSP EDLEAIKNPD SITNQIALLE
      1090       1100       1110       1120       1130       1140
ARCHEMKPNL GAIAEYKKKE ELYLQRVAEL DKITYERDSF RQAYEDLRKQ RLNEFMAGFY
      1150       1160       1170       1180       1190       1200
IITNKLKENY QMLTLGGDAE LELVDSLDPF SEGIMFSVRP PKKSWKKIFN LSGGEKTLSS
      1210       1220       1230       1240       1250       1260
LALVFALHHY KPTPLYFMDE IDAALDFKNV SIVAFYIYEQ TKNAQFIIIS LRNNMFEISD
      1270       1280
RLIGIYKTYN ITKSVAVNPK EIASKGLC

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NTJ3-1-unknown	MPRKGT...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NTJ3-1-unknown	MPRKGT...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90005
Q9NTJ3-25-	GASSDA...	25		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9NTJ3-25-	GASSDA...	25		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9NTJ3-25-	GASSDA...	25		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NTJ3-25-unknown	GASSDA...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13401
Q9NTJ3-25-unknown	GASSDA...	25	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137181
Q9NTJ3-48-unknown	TASEEL...	48	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13403
Q9NTJ3-48-unknown	TASEEL...	48	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138991
Q9NTJ3-64-unknown	SIPPPP...	64	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177768
Q9NTJ3-64-	SIPPPP...	64		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NTJ3-215-unknown	SHGIDL...	215	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177770
Q9NTJ3-215-	SHGIDL...	215		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PPSPDG	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13401
...PPSPDG	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120094
...ATAAET	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13403
...ATAAET	47	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122060
...SKGLC	1288	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SKGLC	1288	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85623

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	24	SPDG.\|.GASS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	47	AAET.\|.TASE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

TopFIND

Q9NTJ3: Structural maintenance of chromosomes protein 4

General Information

8

N-termini

3

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates