Q9NWH9: SAFB-like transcription modulator

General Information

Protein names	- SAFB-like transcription modulator - Modulator of estrogen-induced transcription
Gene names	SLTM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NWH9

8 N-termini

7 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAATGAVAA SAASGQAEGK KITDLRVIDL KSELKRRNLD ITGVKTVLIS RLKQAIEEEG
        70         80         90        100        110        120
GDPDNIELTV STDTPNKKPT KGKGKKHEAD ELSGDASVED DAFIKDCELE NQEAHEQDGN
       130        140        150        160        170        180
DELKDSEEFG ENEEENVHSK ELLSAEENKR AHELIEAEGI EDIEKEDIES QEIEAQEGED
       190        200        210        220        230        240
DTFLTAQDGE EEENEKDIAG SGDGTQEVSK PLPSEGSLAE ADHTAHEEME AHTTVKEAED
       250        260        270        280        290        300
DNISVTIQAE DAITLDFDGD DLLETGKNVK ITDSEASKPK DGQDAIAQSP EKESKDYEMN
       310        320        330        340        350        360
ANHKDGKKED CVKGDPVEKE ARESSKKAES GDKEKDTLKK GPSSTGASGQ AKSSSKESKD
       370        380        390        400        410        420
SKTSSKDDKG STSSTSGSSG SSTKNIWVSG LSSNTKAADL KNLFGKYGKV LSAKVVTNAR
       430        440        450        460        470        480
SPGAKCYGIV TMSSSTEVSR CIAHLHRTEL HGQLISVEKV KGDPSKKEMK KENDEKSSSR
       490        500        510        520        530        540
SSGDKKNTSD RSSKTQASVK KEEKRSSEKS EKKESKDTKK IEGKDEKNDN GASGQTSESI
       550        560        570        580        590        600
KKSEEKKRIS SKSPGHMVIL DQTKGDHCRP SRRGRYEKIH GRSKEKERAS LDKKRDKDYR
       610        620        630        640        650        660
RKEILPFEKM KEQRLREHLV RFERLRRAME LRRRREIAER ERRERERIRI IREREERERL
       670        680        690        700        710        720
QRERERLEIE RQKLERERME RERLERERIR IEQERRKEAE RIAREREELR RQQQQLRYEQ
       730        740        750        760        770        780
EKRNSLKRPR DVDHRRDDPY WSENKKLSLD TDARFGHGSD YSRQQNRFND FDHRERGRFP
       790        800        810        820        830        840
ESSAVQSSSF ERRDRFVGQS EGKKARPTAR REDPSFERYP KNFSDSRRNE PPPPRNELRE
       850        860        870        880        890        900
SDRREVRGER DERRTVIIHD RPDITHPRHP REAGPNPSRP TSWKSEGSMS TDKRETRVER
       910        920        930        940        950        960
PERSGREVSG HSVRGAPPGN RSSASGYGSR EGDRGVITDR GGGSQHYPEE RHVVERHGRD
       970        980        990       1000       1010       1020
TSGPRKEWHG PPSQGPSYHD TRRMGDGRAG AGMITQHSSN ASPINRIVQI SGNSMPRGSG
      1030
SGFKPFKGGP PRRF

Isoforms

- Isoform 2 of SAFB-like transcription modulator

Sequence View

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Evidence Codes:

Methodology:

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Protein Neighborhood

Domains & Features

8 N-termini - 7 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NWH9-2-unknown	MAAATG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NWH9-2-Acetylation	AAATGA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NWH9-2-Acetylation	AAATGA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NWH9-2-Acetylation	AAATGA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NWH9-2-	AAATGA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NWH9-102-	AFIKDC...	102			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NWH9-408-unknown	GKVLSA...	408		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411534
Q9NWH9-432-unknown	MSSSTE...	432		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439271
Q9NWH9-470-unknown	KKENDE...	470		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15060
Q9NWH9-935-unknown	GVITDR...	935		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452805

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DNISVT	245	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453987
...KITDSE	274	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453179
...ANHKDG	305	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453065
...SKKEMK	469	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15060
...KEMKKE	471	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000249736
...SFERYP	819	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453662
...PPRRF	1034	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	469	KEMK.\|.KKEN	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)