Q9NY93: Probable ATP-dependent RNA helicase DDX56

General Information

Protein names	- Probable ATP-dependent RNA helicase DDX56 - 3.6.4.13 - ATP-dependent 61 kDa nucleolar RNA helicase - DEAD box protein 21 - DEAD box protein 56
Gene names	DDX56
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NY93

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEDSEALGFE HMGLDPRLLQ AVTDLGWSRP TLIQEKAIPL ALEGKDLLAR ARTGSGKTAA
        70         80         90        100        110        120
YAIPMLQLLL HRKATGPVVE QAVRGLVLVP TKELARQAQS MIQQLATYCA RDVRVANVSA
       130        140        150        160        170        180
AEDSVSQRAV LMEKPDVVVG TPSRILSHLQ QDSLKLRDSL ELLVVDEADL LFSFGFEEEL
       190        200        210        220        230        240
KSLLCHLPRI YQAFLMSATF NEDVQALKEL ILHNPVTLKL QESQLPGPDQ LQQFQVVCET
       250        260        270        280        290        300
EEDKFLLLYA LLKLSLIRGK SLLFVNTLER SYRLRLFLEQ FSIPTCVLNG ELPLRSRCHI
       310        320        330        340        350        360
ISQFNQGFYD CVIATDAEVL GAPVKGKRRG RGPKGDKASD PEAGVARGID FHHVSAVLNF
       370        380        390        400        410        420
DLPPTPEAYI HRAGRTARAN NPGIVLTFVL PTEQFHLGKI EELLSGENRG PILLPYQFRM
       430        440        450        460        470        480
EEIEGFRYRC RDAMRSVTKQ AIREARLKEI KEELLHSEKL KTYFEDNPRD LQLLRHDLPL
       490        500        510        520        530        540
HPAVVKPHLG HVPDYLVPPA LRGLVRPHKK RKKLSSSCRK AKRAKSQNPL RSFKHKGKKF

RPTAKPS

Isoforms

- Isoform 2 of Probable ATP-dependent RNA helicase DDX56

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NY93-1-acetylation	MEDSEA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NY93-1-acetylation	MEDSEA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NY93-1-acetylation	MEDSEA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162840
Q9NY93-1-unknown	MEDSEA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NY93-1-unknown	MEDSEA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72553
Q9NY93-129-unknown	AVLMEK...	129		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167838
Q9NY93-129-	AVLMEK...	129			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NY93-129-	AVLMEK...	129			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9NY93-129-	AVLMEK...	129			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NY93-317-unknown	AEVLGA...	317		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13448
Q9NY93-455-unknown	LHSEKL...	455		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15074
Q9NY93-455-unknown	LHSEKL...	455		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152258

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VIATDA	316	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13448
...IKEELL	454	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15074
...IKEELL	454	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135668
...TAKPS	547	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TAKPS	547	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68171

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	316	ATDA.\|.AEVL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	454	EELL.\|.LHSE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)