Q9NYV4: Cyclin-dependent kinase 12

General Information

Protein names	- Cyclin-dependent kinase 12 - 2.7.11.22 - 2.7.11.23 - Cdc2-related kinase, arginine/serine-rich - CrkRS - Cell division cycle 2-related protein kinase 7 - CDC2-related protein kinase 7 - Cell division protein kinase 12 - hCDK12
Gene names	CDK12
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NYV4

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPNSERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA
        70         80         90        100        110        120
ASLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GSDRSDRLHK HRHHQHRRSR
       130        140        150        160        170        180
DLLKAKQTEK EKSQEVSSKS GSMKDRISGS SKRSNEETDD YGKAQVAKSS SKESRSSKLH
       190        200        210        220        230        240
KEKTRKEREL KSGHKDRSKS HRKRETPKSY KTVDSPKRRS RSPHRKWSDS SKQDDSPSGA
       250        260        270        280        290        300
SYGQDYDLSP SRSHTSSNYD SYKKSPGSTS RRQSVSPPYK EPSAYQSSTR SPSPYSRRQR
       310        320        330        340        350        360
SVSPYSRRRS SSYERSGSYS GRSPSPYGRR RSSSPFLSKR SLSRSPLPSR KSMKSRSRSP
       370        380        390        400        410        420
AYSRHSSSHS KKKRSSSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES
       430        440        450        460        470        480
KGSPVFLPRK ENSSVEAKDS GLESKKLPRS VKLEKSAPDT ELVNVTHLNT EVKNSSDTGK
       490        500        510        520        530        540
VKLDENSEKH LVKDLKAQGT RDSKPIALKE EIVTPKETET SEKETPPPLP TIASPPPPLP
       550        560        570        580        590        600
TTTPPPQTPP LPPLPPIPAL PQQPPLPPSQ PAFSQVPASS TSTLPPSTHS KTSAVSSQAN
       610        620        630        640        650        660
SQPPVQVSVK TQVSVTAAIP HLKTSTLPPL PLPPLLPGDD DMDSPKETLP SKPVKKEKEQ
       670        680        690        700        710        720
RTRHLLTDLP LPPELPGGDL SPPDSPEPKA ITPPQQPYKK RPKICCPRYG ERRQTESDWG
       730        740        750        760        770        780
KRCVDKFDII GIIGEGTYGQ VYKAKDKDTG ELVALKKVRL DNEKEGFPIT AIREIKILRQ
       790        800        810        820        830        840
LIHRSVVNMK EIVTDKQDAL DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FSEDHIKSFM
       850        860        870        880        890        900
KQLMEGLEYC HKKNFLHRDI KCSNILLNNS GQIKLADFGL ARLYNSEESR PYTNKVITLW
       910        920        930        940        950        960
YRPPELLLGE ERYTPAIDVW SCGCILGELF TKKPIFQANL ELAQLELISR LCGSPCPAVW
       970        980        990       1000       1010       1020
PDVIKLPYFN TMKPKKQYRR RLREEFSFIP SAALDLLDHM LTLDPSKRCT AEQTLQSDFL
      1030       1040       1050       1060       1070       1080
KDVELSKMAP PDLPHWQDCH ELWSKKRRRQ RQSGVVVEEP PPSKTSRKET TSGTSTEPVK
      1090       1100       1110       1120       1130       1140
NSSPAPPQPA PGKVESGAGD AIGLADITQQ LNQSELAVLL NLLQSQTDLS IPQMAQLLNI
      1150       1160       1170       1180       1190       1200
HSNPEMQQQL EALNQSISAL TEATSQQQDS ETMAPEESLK EAPSAPVILP SAEQTTLEAS
      1210       1220       1230       1240       1250       1260
STPADMQNIL AVLLSQLMKT QEPAGSLEEN NSDKNSGPQG PRRTPTMPQE EAAACPPHIL
      1270       1280       1290       1300       1310       1320
PPEKRPPEPP GPPPPPPPPP LVEGDLSSAP QELNPAVTAA LLQLLSQPEA EPPGHLPHEH
      1330       1340       1350       1360       1370       1380
QALRPMEYST RPRPNRTYGN TDGPETGFSA IDTDERNSGP ALTESLVQTL VKNRTFSGSL
      1390       1400       1410       1420       1430       1440
SHLGESSSYQ GTGSVQFPGD QDLRFARVPL ALHPVVGQPF LKAEGSSNSV VHAETKLQNY
      1450       1460       1470       1480       1490
GELGPGTTGA SSSGAGLHWG GPTQSSAYGK LYRGPTRVPP RGGRGRGVPY

Isoforms

- Isoform 2 of Cyclin-dependent kinase 12 - Isoform 3 of Cyclin-dependent kinase 12

Sequence View

        10         20         30         40         50         60
MPNSERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA
        70         80         90        100        110        120
ASLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GSDRSDRLHK HRHHQHRRSR
       130        140        150        160        170        180
DLLKAKQTEK EKSQEVSSKS GSMKDRISGS SKRSNEETDD YGKAQVAKSS SKESRSSKLH
       190        200        210        220        230        240
KEKTRKEREL KSGHKDRSKS HRKRETPKSY KTVDSPKRRS RSPHRKWSDS SKQDDSPSGA
       250        260        270        280        290        300
SYGQDYDLSP SRSHTSSNYD SYKKSPGSTS RRQSVSPPYK EPSAYQSSTR SPSPYSRRQR
       310        320        330        340        350        360
SVSPYSRRRS SSYERSGSYS GRSPSPYGRR RSSSPFLSKR SLSRSPLPSR KSMKSRSRSP
       370        380        390        400        410        420
AYSRHSSSHS KKKRSSSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES
       430        440        450        460        470        480
KGSPVFLPRK ENSSVEAKDS GLESKKLPRS VKLEKSAPDT ELVNVTHLNT EVKNSSDTGK
       490        500        510        520        530        540
VKLDENSEKH LVKDLKAQGT RDSKPIALKE EIVTPKETET SEKETPPPLP TIASPPPPLP
       550        560        570        580        590        600
TTTPPPQTPP LPPLPPIPAL PQQPPLPPSQ PAFSQVPASS TSTLPPSTHS KTSAVSSQAN
       610        620        630        640        650        660
SQPPVQVSVK TQVSVTAAIP HLKTSTLPPL PLPPLLPGDD DMDSPKETLP SKPVKKEKEQ
       670        680        690        700        710        720
RTRHLLTDLP LPPELPGGDL SPPDSPEPKA ITPPQQPYKK RPKICCPRYG ERRQTESDWG
       730        740        750        760        770        780
KRCVDKFDII GIIGEGTYGQ VYKAKDKDTG ELVALKKVRL DNEKEGFPIT AIREIKILRQ
       790        800        810        820        830        840
LIHRSVVNMK EIVTDKQDAL DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FSEDHIKSFM
       850        860        870        880        890        900
KQLMEGLEYC HKKNFLHRDI KCSNILLNNS GQIKLADFGL ARLYNSEESR PYTNKVITLW
       910        920        930        940        950        960
YRPPELLLGE ERYTPAIDVW SCGCILGELF TKKPIFQANL ELAQLELISR LCGSPCPAVW
       970        980        990       1000       1010       1020
PDVIKLPYFN TMKPKKQYRR RLREEFSFIP SAALDLLDHM LTLDPSKRCT AEQTLQSDFL
      1030       1040       1050       1060       1070       1080
KDVELSKMAP PDLPHWQDCH ELWSKKRRRQ RQSGVVVEEP PPSKTSRKET TSGTSTEPVK
      1090       1100       1110       1120       1130       1140
NSSPAPPQPA PGKVESGAGD AIGLADITQQ LNQSELAVLL NLLQSQTDLS IPQMAQLLNI
      1150       1160       1170       1180       1190       1200
HSNPEMQQQL EALNQSISAL TEATSQQQDS ETMAPEESLK EAPSAPVILP SAEQTTLEAS
      1210       1220       1230       1240       1250       1260
STPADMQNIL AVLLSQLMKT QEPAGSLEEN NSDKNSGPQG PRRTPTMPQE EAAACPPHIL
      1270       1280       1290       1300       1310       1320
PPEKRPPEPP GPPPPPPPPP LVEGDLSSAP QELNPAVTAA LLQLLSQPEA EPPGHLPHEH
      1330       1340       1350       1360       1370       1380
QALRPMEYST RPRPNRTYGN TDGPETGFSA IDTDERNSGP ALTESLVQTL VKNRTFSGSL
      1390       1400       1410       1420       1430       1440
SHLGESSSYQ GTGSVQFPGD QDLRFARVPL ALHPVVGQPF LKAEGSSNSV VHAETKLQNY
      1450       1460       1470       1480       1490
GELGPGTTGA SSSGAGLHWG GPTQSSAYGK LYRGPTRVPP RGGRGRGVPY         10         20         30         40         50         60
MPNSERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA
        70         80         90        100        110        120
ASLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GSDRSDRLHK HRHHQHRRSR
       130        140        150        160        170        180
DLLKAKQTEK EKSQEVSSKS GSMKDRISGS SKRSNEETDD YGKAQVAKSS SKESRSSKLH
       190        200        210        220        230        240
KEKTRKEREL KSGHKDRSKS HRKRETPKSY KTVDSPKRRS RSPHRKWSDS SKQDDSPSGA
       250        260        270        280        290        300
SYGQDYDLSP SRSHTSSNYD SYKKSPGSTS RRQSVSPPYK EPSAYQSSTR SPSPYSRRQR
       310        320        330        340        350        360
SVSPYSRRRS SSYERSGSYS GRSPSPYGRR RSSSPFLSKR SLSRSPLPSR KSMKSRSRSP
       370        380        390        400        410        420
AYSRHSSSHS KKKRSSSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES
       430        440        450        460        470        480
KGSPVFLPRK ENSSVEAKDS GLESKKLPRS VKLEKSAPDT ELVNVTHLNT EVKNSSDTGK
       490        500        510        520        530        540
VKLDENSEKH LVKDLKAQGT RDSKPIALKE EIVTPKETET SEKETPPPLP TIASPPPPLP
       550        560        570        580        590        600
TTTPPPQTPP LPPLPPIPAL PQQPPLPPSQ PAFSQVPASS TSTLPPSTHS KTSAVSSQAN
       610        620        630        640        650        660
SQPPVQVSVK TQVSVTAAIP HLKTSTLPPL PLPPLLPGDD DMDSPKETLP SKPVKKEKEQ
       670        680        690        700        710        720
RTRHLLTDLP LPPELPGGDL SPPDSPEPKA ITPPQQPYKK RPKICCPRYG ERRQTESDWG
       730        740        750        760        770        780
KRCVDKFDII GIIGEGTYGQ VYKAKDKDTG ELVALKKVRL DNEKEGFPIT AIREIKILRQ
       790        800        810        820        830        840
LIHRSVVNMK EIVTDKQDAL DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FSEDHIKSFM
       850        860        870        880        890        900
KQLMEGLEYC HKKNFLHRDI KCSNILLNNS GQIKLADFGL ARLYNSEESR PYTNKVITLW
       910        920        930        940        950        960
YRPPELLLGE ERYTPAIDVW SCGCILGELF TKKPIFQANL ELAQLELISR LCGSPCPAVW
       970        980        990       1000       1010       1020
PDVIKLPYFN TMKPKKQYRR RLREEFSFIP SAALDLLDHM LTLDPSKRCT AEQTLQSDFL
      1030       1040       1050       1060       1070       1080
KDVELSKMAP PDLPHWQDCH ELWSKKRRRQ RQSGVVVEEP PPSKTSRKET TSGTSTEPVK
      1090       1100       1110       1120       1130       1140
NSSPAPPQPA PGKVESGAGD AIGLADITQQ LNQSELAVLL NLLQSQTDLS IPQMAQLLNI
      1150       1160       1170       1180       1190       1200
HSNPEMQQQL EALNQSISAL TEATSQQQDS ETMAPEESLK EAPSAPVILP SAEQTTLEAS
      1210       1220       1230       1240       1250       1260
STPADMQNIL AVLLSQLMKT QEPAGSLEEN NSDKNSGPQG PRRTPTMPQE EAAACPPHIL
      1270       1280       1290       1300       1310       1320
PPEKRPPEPP GPPPPPPPPP LVEGDLSSAP QELNPAVTAA LLQLLSQPEA EPPGHLPHEH
      1330       1340       1350       1360       1370       1380
QALRPMEYST RPRPNRTYGN TDGPETGFSA IDTDERNSGP ALTESLVQTL VKNRTFSGSL
      1390       1400       1410       1420       1430       1440
SHLGESSSYQ GTGSVQFPGD QDLRFARVPL ALHPVVGQPF LKAEGSSNSV VHAETKLQNY
      1450       1460       1470       1480       1490
GELGPGTTGA SSSGAGLHWG GPTQSSAYGK LYRGPTRVPP RGGRGRGVPY

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NYV4-1-unknown	MPNSER...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NYV4-1-unknown	MPNSER...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70078
Q9NYV4-1-unknown	MPNSER...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70079
Q9NYV4-460-unknown	TELVNV...	460	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13464
Q9NYV4-460-unknown	TELVNV...	460	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152900
Q9NYV4-460-unknown	TELVNV...	460	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152915
Q9NYV4-1347-	GFSAID...	1347		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NYV4-1347-unknown	GFSAID...	1347	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171735

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KSAPDT	459	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13464
...KSAPDT	459	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136325
...KSAPDT	459	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136341
...RGVPY	1490	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RGVPY	1490	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65696

TopFIND

Q9NYV4: Cyclin-dependent kinase 12

General Information

4

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates