Q9NZ63: Telomere length and silencing protein 1 homolog {ECO:0000250|UniProtKB:Q10148}

General Information

Protein names	- Telomere length and silencing protein 1 homolog {ECO:0000250\|UniProtKB:Q10148} - Hepatocellular carcinoma-associated antigen 59
Gene names	C9orf78
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NZ63

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPVVRKIFRR RRGDSESEED EQDSEEVRLK LEETREVQNL RKRPNGVSAV ALLVGEKVQE
        70         80         90        100        110        120
ETTLVDDPFQ MKTGGMVDMK KLKERGKDKI SEEEDLHLGT SFSAETNRRD EDADMMKYIE
       130        140        150        160        170        180
TELKKRKGIV EHEEQKVKPK NAEDCLYELP ENIRVSSAKK TEEMLSNQML SGIPEVDLGI
       190        200        210        220        230        240
DAKIKNIIST EDAKARLLAE QQNKKKDSET SFVPTNMAVN YVQHNRFYHE ELNAPIRRNK
       250        260        270        280
EEPKARPLRV GDTEKPEPER SPPNRKRPAN EKATDDYHYE KFKKMNRRY

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NZ63-1-unknown	MPVVRK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NZ63-172-	GIPEVD...	172		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NZ63-178-unknown	LGIDAK...	178	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13467
Q9NZ63-218-	AVNYVQ...	218		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...IPEVDL	177	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13467
	...MNRRY	289	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	177	EVDL.\|.LGID	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)