Q9NZN8: CCR4-NOT transcription complex subunit 2

General Information

Protein names	- CCR4-NOT transcription complex subunit 2 - CCR4-associated factor 2
Gene names	CNOT2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NZN8

11 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of CCR4-NOT transcription complex subunit 2 - Isoform 3 of CCR4-NOT transcription complex subunit 2 - Isoform 4 of CCR4-NOT transcription complex subunit 2 - Isoform 5 of CCR4-NOT transcription complex subunit 2

Sequence View

        10         20         30         40         50         60
MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF PHRSEKDMLA
        70         80         90        100        110        120
SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL SQGTQLPSHV TPTTGVPTMS
       130        140        150        160        170        180
LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ
       190        200        210        220        230        240
PSRQPFTVNS MSGFGMNRNQ AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE
       250        260        270        280        290        300
GSGNPTPLIN PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS
       310        320        330        340        350        360
NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM VTDQFGMIGL
       370        380        390        400        410        420
LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA SPWASSPCRP QDIDFHVPSE
       430        440        450        460        470        480
YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM NGGDVLQLLA AVELFNRDWR YHKEERVWIT
       490        500        510        520        530        540
RAPGMEPTMK TNTYERGTYY FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF

        10         20         30         40         50         60
MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF PHRSEKDMLA
        70         80         90        100        110        120
SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL SQGTQLPSHV TPTTGVPTMS
       130        140        150        160        170        180
LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ
       190        200        210        220        230        240
PSRQPFTVNS MSGFGMNRNQ AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE
       250        260        270        280        290        300
GSGNPTPLIN PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS
       310        320        330        340        350        360
NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM VTDQFGMIGL
       370        380        390        400        410        420
LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA SPWASSPCRP QDIDFHVPSE
       430        440        450        460        470        480
YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM NGGDVLQLLA AVELFNRDWR YHKEERVWIT
       490        500        510        520        530        540
RAPGMEPTMK TNTYERGTYY FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF

        10         20         30         40         50         60
MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF PHRSEKDMLA
        70         80         90        100        110        120
SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL SQGTQLPSHV TPTTGVPTMS
       130        140        150        160        170        180
LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ
       190        200        210        220        230        240
PSRQPFTVNS MSGFGMNRNQ AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE
       250        260        270        280        290        300
GSGNPTPLIN PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS
       310        320        330        340        350        360
NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM VTDQFGMIGL
       370        380        390        400        410        420
LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA SPWASSPCRP QDIDFHVPSE
       430        440        450        460        470        480
YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM NGGDVLQLLA AVELFNRDWR YHKEERVWIT
       490        500        510        520        530        540
RAPGMEPTMK TNTYERGTYY FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF

        10         20         30         40         50         60
MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF PHRSEKDMLA
        70         80         90        100        110        120
SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL SQGTQLPSHV TPTTGVPTMS
       130        140        150        160        170        180
LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ
       190        200        210        220        230        240
PSRQPFTVNS MSGFGMNRNQ AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE
       250        260        270        280        290        300
GSGNPTPLIN PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS
       310        320        330        340        350        360
NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM VTDQFGMIGL
       370        380        390        400        410        420
LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA SPWASSPCRP QDIDFHVPSE
       430        440        450        460        470        480
YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM NGGDVLQLLA AVELFNRDWR YHKEERVWIT
       490        500        510        520        530        540
RAPGMEPTMK TNTYERGTYY FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NZN8-1-unknown	MVRTDG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NZN8-1-unknown	MVRTDG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71173
Q9NZN8-1-unknown	MVRTDG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71174
Q9NZN8-37-unknown	YHDENM...	37	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13476
Q9NZN8-37-unknown	YHDENM...	37	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138123
Q9NZN8-37-unknown	YHDENM...	37	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138124
Q9NZN8-120-unknown	SLHTPP...	120	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167619
Q9NZN8-120-unknown	SLHTPP...	120	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167620
Q9NZN8-120-	SLHTPP...	120		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NZN8-120-	SLHTPP...	120		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NZN8-120-	SLHTPP...	120		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9NZN8-120-	SLHTPP...	120		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NZN8-176-unknown	MPKQQP...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71171
Q9NZN8-176-unknown	MPKQQP...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt95903
Q9NZN8-176-unknown	MPKQQP...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt95904
Q9NZN8-241-unknown	GSGNPT...	241	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175539
Q9NZN8-241-unknown	GSGNPT...	241	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175538
Q9NZN8-241-	GSGNPT...	241		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9NZN8-243-unknown	GNPTPL...	243	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175536
Q9NZN8-243-unknown	GNPTPL...	243	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175535
Q9NZN8-243-	GNPTPL...	243		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9NZN8-316-unknown	KFPGDK...	316		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NZN8-316-unknown	KFPGDK...	316	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161398
Q9NZN8-316-unknown	KFPGDK...	316	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161396
Q9NZN8-316-unknown	KFPGDK...	316	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161397
Q9NZN8-350-unknown	MVTDQF...	350	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71172
Q9NZN8-350-unknown	MVTDQF...	350	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt95971
Q9NZN8-350-unknown	MVTDQF...	350	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt95969
Q9NZN8-350-unknown	MVTDQF...	350	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt95970

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVDSDY	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13476
...GVDSDY	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121148
...GVDSDY	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121149
...AQQAF	540	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AQQAF	540	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66790
...AQQAF	540	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66789
...AQQAF	540	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66792

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	36	DSDY.\|.YHDE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)