Q9P107: GEM-interacting protein

General Information

Protein names	- GEM-interacting protein - GMIP
Gene names	GMIP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9P107

8 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDAAEPGLPP GPEGRKRYSD IFRSLDNLEI SLGNVTLEML AGDPLLSEDP EPDKTPTATV
        70         80         90        100        110        120
TNEASCWSGP SPEGPVPLTG EELDLRLIRT KGGVDAALEY AKTWSRYAKE LLAWTEKRAS
       130        140        150        160        170        180
YELEFAKSTM KIAEAGKVSI QQQSHMPLQY IYTLFLEHDL SLGTLAMETV AQQKRDYYQP
       190        200        210        220        230        240
LAAKRTEIEK WRKEFKEQWM KEQKRMNEAV QALRRAQLQY VQRSEDLRAR SQGSPEDSAP
       250        260        270        280        290        300
QASPGPSKQQ ERRRRSREEA QAKAQEAEAL YQACVREANA RQQDLEIAKQ RIVSHVRKLV
       310        320        330        340        350        360
FQGDEVLRRV TLSLFGLRGA QAERGPRAFA ALAECCAPFE PGQRYQEFVR ALRPEAPPPP
       370        380        390        400        410        420
PPAFSFQEFL PSLNSSPLDI RKKLSGPLPP RLDENSAEPG PWEDPGTGWR WQGTPGPTPG
       430        440        450        460        470        480
SDVDSVGGGS ESRSLDSPTS SPGAGTRQLV KASSTGTESS DDFEERDPDL GDGLENGLGS
       490        500        510        520        530        540
PFGKWTLSSA AQTHQLRRLR GPAKCRECEA FMVSGTECEE CFLTCHKRCL ETLLILCGHR
       550        560        570        580        590        600
RLPARTPLFG VDFLQLPRDF PEEVPFVVTK CTAEIEHRAL DVQGIYRVSG SRVRVERLCQ
       610        620        630        640        650        660
AFENGRALVE LSGNSPHDVS SVLKRFLQEL TEPVIPFHLY DAFISLAKTL HADPGDDPGT
       670        680        690        700        710        720
PSPSPEVIRS LKTLLVQLPD SNYNTLRHLV AHLFRVAARF MENKMSANNL GIVFGPTLLR
       730        740        750        760        770        780
PPDGPRAASA IPVTCLLDSG HQAQLVEFLI VHYEQIFGMD ELPQATEPPP QDSSPAPGPL
       790        800        810        820        830        840
TTSSQPPPPH LDPDSQPPVL ASDPGPDPQH HSTLEQHPTA TPTEIPTPQS DQREDVAEDT
       850        860        870        880        890        900
KDGGGEVSSQ GPEDSLLGTQ SRGHFSRQPV KYPRGGVRPV THQLSSLALV ASKLCEETPI
       910        920        930        940        950        960
TSVPRGSLRG RGPSPAAASP EGSPLRRTPL PKHFEITQET ARLLSKLDSE AVPRATCCPD
       970
VQPEEAEDHL

Isoforms

- Isoform 2 of GEM-interacting protein

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9P107-1-acetylation	MDAAEP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9P107-1-unknown	MDAAEP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9P107-39-unknown	MLAGDP...	39		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467946
Q9P107-425-	SVGGGS...	425			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9P107-473-unknown	GLENGL...	473			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9P107-473-	GLENGL...	473			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9P107-473-	GLENGL...	473			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9P107-843-unknown	GGGEVS...	843		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2330
Q9P107-843-	GGGEVS...	843			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9P107-843-	GGGEVS...	843			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9P107-843-	GGGEVS...	843			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9P107-843-	GGGEVS...	843			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...STMKIA	132	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467946
...QLPRDF	559	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000465108
...EDTKDG	842	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2330
...AEDHL	970	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...AEDHL	970		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...AEDHL	970		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	842	TKDG.\|.GGGE	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> GMIP_HUMAN @842

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)