Q9UBC3: DNA (cytosine-5)-methyltransferase 3B

General Information

Protein names	- DNA (cytosine-5)-methyltransferase 3B - Dnmt3b - 2.1.1.37 - DNA methyltransferase HsaIIIB - DNA MTase HsaIIIB - M.HsaIIIB
Gene names	DNMT3B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UBC3

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of DNA (cytosine-5)-methyltransferase 3B - Isoform 3 of DNA (cytosine-5)-methyltransferase 3B - Isoform 4 of DNA (cytosine-5)-methyltransferase 3B - Isoform 5 of DNA (cytosine-5)-methyltransferase 3B - Isoform 6 of DNA (cytosine-5)-methyltransferase 3B - Isoform 7 of DNA (cytosine-5)-methyltransferase 3B - Isoform 8 of DNA (cytosine-5)-methyltransferase 3B

Sequence View

        10         20         30         40         50         60
MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV
        70         80         90        100        110        120
SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES PAVRTRNNNS VSSRERHRPS
       130        140        150        160        170        180
PRSTRGRQGR NHVDESPVEF PATRSLRRRA TASAGTPWPS PPSSYLTIDL TDDTEDTHGT
       190        200        210        220        230        240
PQSSSTPYAR LAQDSQQGGM ESPQVEADSG DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP
       250        260        270        280        290        300
AMVVSWKATS KRQAMSGMRW VQWFGDGKFS EVSADKLVAL GLFSQHFNLA TFNKLVSYRK
       310        320        330        340        350        360
AMYHALEKAR VRAGKTFPSS PGDSLEDQLK PMLEWAHGGF KPTGIEGLKP NNTQPVVNKS
       370        380        390        400        410        420
KVRRAGSRKL ESRKYENKTR RRTADDSATS DYCPAPKRLK TNCYNNGKDR GDEDQSREQM
       430        440        450        460        470        480
ASDVANNKSS LEDGCLSCGR KNPVSFHPLF EGGLCQTCRD RFLELFYMYD DDGYQSYCTV
       490        500        510        520        530        540
CCEGRELLLC SNTSCCRCFC VECLEVLVGT GTAAEAKLQE PWSCYMCLPQ RCHGVLRRRK
       550        560        570        580        590        600
DWNVRLQAFF TSDTGLEYEA PKLYPAIPAA RRRPIRVLSL FDGIATGYLV LKELGIKVGK
       610        620        630        640        650        660
YVASEVCEES IAVGTVKHEG NIKYVNDVRN ITKKNIEEWG PFDLVIGGSP CNDLSNVNPA
       670        680        690        700        710        720
RKGLYEGTGR LFFEFYHLLN YSRPKEGDDR PFFWMFENVV AMKVGDKRDI SRFLECNPVM
       730        740        750        760        770        780
IDAIKVSAAH RARYFWGNLP GMNRPVIASK NDKLELQDCL EYNRIAKLKK VQTITTKSNS
       790        800        810        820        830        840
IKQGKNQLFP VVMNGKEDVL WCTELERIFG FPVHYTDVSN MGRGARQKLL GRSWSVPVIR
       850
HLFAPLKDYF ACE         10         20         30         40         50         60
MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV
        70         80         90        100        110        120
SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES PAVRTRNNNS VSSRERHRPS
       130        140        150        160        170        180
PRSTRGRQGR NHVDESPVEF PATRSLRRRA TASAGTPWPS PPSSYLTIDL TDDTEDTHGT
       190        200        210        220        230        240
PQSSSTPYAR LAQDSQQGGM ESPQVEADSG DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP
       250        260        270        280        290        300
AMVVSWKATS KRQAMSGMRW VQWFGDGKFS EVSADKLVAL GLFSQHFNLA TFNKLVSYRK
       310        320        330        340        350        360
AMYHALEKAR VRAGKTFPSS PGDSLEDQLK PMLEWAHGGF KPTGIEGLKP NNTQPVVNKS
       370        380        390        400        410        420
KVRRAGSRKL ESRKYENKTR RRTADDSATS DYCPAPKRLK TNCYNNGKDR GDEDQSREQM
       430        440        450        460        470        480
ASDVANNKSS LEDGCLSCGR KNPVSFHPLF EGGLCQTCRD RFLELFYMYD DDGYQSYCTV
       490        500        510        520        530        540
CCEGRELLLC SNTSCCRCFC VECLEVLVGT GTAAEAKLQE PWSCYMCLPQ RCHGVLRRRK
       550        560        570        580        590        600
DWNVRLQAFF TSDTGLEYEA PKLYPAIPAA RRRPIRVLSL FDGIATGYLV LKELGIKVGK
       610        620        630        640        650        660
YVASEVCEES IAVGTVKHEG NIKYVNDVRN ITKKNIEEWG PFDLVIGGSP CNDLSNVNPA
       670        680        690        700        710        720
RKGLYEGTGR LFFEFYHLLN YSRPKEGDDR PFFWMFENVV AMKVGDKRDI SRFLECNPVM
       730        740        750        760        770        780
IDAIKVSAAH RARYFWGNLP GMNRPVIASK NDKLELQDCL EYNRIAKLKK VQTITTKSNS
       790        800        810        820        830        840
IKQGKNQLFP VVMNGKEDVL WCTELERIFG FPVHYTDVSN MGRGARQKLL GRSWSVPVIR
       850
HLFAPLKDYF ACE         10         20         30         40         50         60
MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV
        70         80         90        100        110        120
SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES PAVRTRNNNS VSSRERHRPS
       130        140        150        160        170        180
PRSTRGRQGR NHVDESPVEF PATRSLRRRA TASAGTPWPS PPSSYLTIDL TDDTEDTHGT
       190        200        210        220        230        240
PQSSSTPYAR LAQDSQQGGM ESPQVEADSG DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP
       250        260        270        280        290        300
AMVVSWKATS KRQAMSGMRW VQWFGDGKFS EVSADKLVAL GLFSQHFNLA TFNKLVSYRK
       310        320        330        340        350        360
AMYHALEKAR VRAGKTFPSS PGDSLEDQLK PMLEWAHGGF KPTGIEGLKP NNTQPVVNKS
       370        380        390        400        410        420
KVRRAGSRKL ESRKYENKTR RRTADDSATS DYCPAPKRLK TNCYNNGKDR GDEDQSREQM
       430        440        450        460        470        480
ASDVANNKSS LEDGCLSCGR KNPVSFHPLF EGGLCQTCRD RFLELFYMYD DDGYQSYCTV
       490        500        510        520        530        540
CCEGRELLLC SNTSCCRCFC VECLEVLVGT GTAAEAKLQE PWSCYMCLPQ RCHGVLRRRK
       550        560        570        580        590        600
DWNVRLQAFF TSDTGLEYEA PKLYPAIPAA RRRPIRVLSL FDGIATGYLV LKELGIKVGK
       610        620        630        640        650        660
YVASEVCEES IAVGTVKHEG NIKYVNDVRN ITKKNIEEWG PFDLVIGGSP CNDLSNVNPA
       670        680        690        700        710        720
RKGLYEGTGR LFFEFYHLLN YSRPKEGDDR PFFWMFENVV AMKVGDKRDI SRFLECNPVM
       730        740        750        760        770        780
IDAIKVSAAH RARYFWGNLP GMNRPVIASK NDKLELQDCL EYNRIAKLKK VQTITTKSNS
       790        800        810        820        830        840
IKQGKNQLFP VVMNGKEDVL WCTELERIFG FPVHYTDVSN MGRGARQKLL GRSWSVPVIR
       850
HLFAPLKDYF ACE         10         20         30         40         50         60
MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV
        70         80         90        100        110        120
SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES PAVRTRNNNS VSSRERHRPS
       130        140        150        160        170        180
PRSTRGRQGR NHVDESPVEF PATRSLRRRA TASAGTPWPS PPSSYLTIDL TDDTEDTHGT
       190        200        210        220        230        240
PQSSSTPYAR LAQDSQQGGM ESPQVEADSG DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP
       250        260        270        280        290        300
AMVVSWKATS KRQAMSGMRW VQWFGDGKFS EVSADKLVAL GLFSQHFNLA TFNKLVSYRK
       310        320        330        340        350        360
AMYHALEKAR VRAGKTFPSS PGDSLEDQLK PMLEWAHGGF KPTGIEGLKP NNTQPVVNKS
       370        380        390        400        410        420
KVRRAGSRKL ESRKYENKTR RRTADDSATS DYCPAPKRLK TNCYNNGKDR GDEDQSREQM
       430        440        450        460        470        480
ASDVANNKSS LEDGCLSCGR KNPVSFHPLF EGGLCQTCRD RFLELFYMYD DDGYQSYCTV
       490        500        510        520        530        540
CCEGRELLLC SNTSCCRCFC VECLEVLVGT GTAAEAKLQE PWSCYMCLPQ RCHGVLRRRK
       550        560        570        580        590        600
DWNVRLQAFF TSDTGLEYEA PKLYPAIPAA RRRPIRVLSL FDGIATGYLV LKELGIKVGK
       610        620        630        640        650        660
YVASEVCEES IAVGTVKHEG NIKYVNDVRN ITKKNIEEWG PFDLVIGGSP CNDLSNVNPA
       670        680        690        700        710        720
RKGLYEGTGR LFFEFYHLLN YSRPKEGDDR PFFWMFENVV AMKVGDKRDI SRFLECNPVM
       730        740        750        760        770        780
IDAIKVSAAH RARYFWGNLP GMNRPVIASK NDKLELQDCL EYNRIAKLKK VQTITTKSNS
       790        800        810        820        830        840
IKQGKNQLFP VVMNGKEDVL WCTELERIFG FPVHYTDVSN MGRGARQKLL GRSWSVPVIR
       850
HLFAPLKDYF ACE         10         20         30         40         50         60
MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV
        70         80         90        100        110        120
SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES PAVRTRNNNS VSSRERHRPS
       130        140        150        160        170        180
PRSTRGRQGR NHVDESPVEF PATRSLRRRA TASAGTPWPS PPSSYLTIDL TDDTEDTHGT
       190        200        210        220        230        240
PQSSSTPYAR LAQDSQQGGM ESPQVEADSG DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP
       250        260        270        280        290        300
AMVVSWKATS KRQAMSGMRW VQWFGDGKFS EVSADKLVAL GLFSQHFNLA TFNKLVSYRK
       310        320        330        340        350        360
AMYHALEKAR VRAGKTFPSS PGDSLEDQLK PMLEWAHGGF KPTGIEGLKP NNTQPVVNKS
       370        380        390        400        410        420
KVRRAGSRKL ESRKYENKTR RRTADDSATS DYCPAPKRLK TNCYNNGKDR GDEDQSREQM
       430        440        450        460        470        480
ASDVANNKSS LEDGCLSCGR KNPVSFHPLF EGGLCQTCRD RFLELFYMYD DDGYQSYCTV
       490        500        510        520        530        540
CCEGRELLLC SNTSCCRCFC VECLEVLVGT GTAAEAKLQE PWSCYMCLPQ RCHGVLRRRK
       550        560        570        580        590        600
DWNVRLQAFF TSDTGLEYEA PKLYPAIPAA RRRPIRVLSL FDGIATGYLV LKELGIKVGK
       610        620        630        640        650        660
YVASEVCEES IAVGTVKHEG NIKYVNDVRN ITKKNIEEWG PFDLVIGGSP CNDLSNVNPA
       670        680        690        700        710        720
RKGLYEGTGR LFFEFYHLLN YSRPKEGDDR PFFWMFENVV AMKVGDKRDI SRFLECNPVM
       730        740        750        760        770        780
IDAIKVSAAH RARYFWGNLP GMNRPVIASK NDKLELQDCL EYNRIAKLKK VQTITTKSNS
       790        800        810        820        830        840
IKQGKNQLFP VVMNGKEDVL WCTELERIFG FPVHYTDVSN MGRGARQKLL GRSWSVPVIR
       850
HLFAPLKDYF ACE         10         20         30         40         50         60
MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV
        70         80         90        100        110        120
SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES PAVRTRNNNS VSSRERHRPS
       130        140        150        160        170        180
PRSTRGRQGR NHVDESPVEF PATRSLRRRA TASAGTPWPS PPSSYLTIDL TDDTEDTHGT
       190        200        210        220        230        240
PQSSSTPYAR LAQDSQQGGM ESPQVEADSG DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP
       250        260        270        280        290        300
AMVVSWKATS KRQAMSGMRW VQWFGDGKFS EVSADKLVAL GLFSQHFNLA TFNKLVSYRK
       310        320        330        340        350        360
AMYHALEKAR VRAGKTFPSS PGDSLEDQLK PMLEWAHGGF KPTGIEGLKP NNTQPVVNKS
       370        380        390        400        410        420
KVRRAGSRKL ESRKYENKTR RRTADDSATS DYCPAPKRLK TNCYNNGKDR GDEDQSREQM
       430        440        450        460        470        480
ASDVANNKSS LEDGCLSCGR KNPVSFHPLF EGGLCQTCRD RFLELFYMYD DDGYQSYCTV
       490        500        510        520        530        540
CCEGRELLLC SNTSCCRCFC VECLEVLVGT GTAAEAKLQE PWSCYMCLPQ RCHGVLRRRK
       550        560        570        580        590        600
DWNVRLQAFF TSDTGLEYEA PKLYPAIPAA RRRPIRVLSL FDGIATGYLV LKELGIKVGK
       610        620        630        640        650        660
YVASEVCEES IAVGTVKHEG NIKYVNDVRN ITKKNIEEWG PFDLVIGGSP CNDLSNVNPA
       670        680        690        700        710        720
RKGLYEGTGR LFFEFYHLLN YSRPKEGDDR PFFWMFENVV AMKVGDKRDI SRFLECNPVM
       730        740        750        760        770        780
IDAIKVSAAH RARYFWGNLP GMNRPVIASK NDKLELQDCL EYNRIAKLKK VQTITTKSNS
       790        800        810        820        830        840
IKQGKNQLFP VVMNGKEDVL WCTELERIFG FPVHYTDVSN MGRGARQKLL GRSWSVPVIR
       850
HLFAPLKDYF ACE         10         20         30         40         50         60
MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV
        70         80         90        100        110        120
SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES PAVRTRNNNS VSSRERHRPS
       130        140        150        160        170        180
PRSTRGRQGR NHVDESPVEF PATRSLRRRA TASAGTPWPS PPSSYLTIDL TDDTEDTHGT
       190        200        210        220        230        240
PQSSSTPYAR LAQDSQQGGM ESPQVEADSG DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP
       250        260        270        280        290        300
AMVVSWKATS KRQAMSGMRW VQWFGDGKFS EVSADKLVAL GLFSQHFNLA TFNKLVSYRK
       310        320        330        340        350        360
AMYHALEKAR VRAGKTFPSS PGDSLEDQLK PMLEWAHGGF KPTGIEGLKP NNTQPVVNKS
       370        380        390        400        410        420
KVRRAGSRKL ESRKYENKTR RRTADDSATS DYCPAPKRLK TNCYNNGKDR GDEDQSREQM
       430        440        450        460        470        480
ASDVANNKSS LEDGCLSCGR KNPVSFHPLF EGGLCQTCRD RFLELFYMYD DDGYQSYCTV
       490        500        510        520        530        540
CCEGRELLLC SNTSCCRCFC VECLEVLVGT GTAAEAKLQE PWSCYMCLPQ RCHGVLRRRK
       550        560        570        580        590        600
DWNVRLQAFF TSDTGLEYEA PKLYPAIPAA RRRPIRVLSL FDGIATGYLV LKELGIKVGK
       610        620        630        640        650        660
YVASEVCEES IAVGTVKHEG NIKYVNDVRN ITKKNIEEWG PFDLVIGGSP CNDLSNVNPA
       670        680        690        700        710        720
RKGLYEGTGR LFFEFYHLLN YSRPKEGDDR PFFWMFENVV AMKVGDKRDI SRFLECNPVM
       730        740        750        760        770        780
IDAIKVSAAH RARYFWGNLP GMNRPVIASK NDKLELQDCL EYNRIAKLKK VQTITTKSNS
       790        800        810        820        830        840
IKQGKNQLFP VVMNGKEDVL WCTELERIFG FPVHYTDVSN MGRGARQKLL GRSWSVPVIR
       850
HLFAPLKDYF ACE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UBC3-1-unknown	MKGDTR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UBC3-1-unknown	MKGDTR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73077
Q9UBC3-1-unknown	MKGDTR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73078
Q9UBC3-1-unknown	MKGDTR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73079
Q9UBC3-1-unknown	MKGDTR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73080
Q9UBC3-1-unknown	MKGDTR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73082
Q9UBC3-1-unknown	MKGDTR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73083
Q9UBC3-1-unknown	MKGDTR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102566
Q9UBC3-65-unknown	SYTQDL...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176968
Q9UBC3-65-unknown	SYTQDL...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176970
Q9UBC3-65-unknown	SYTQDL...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176971
Q9UBC3-65-unknown	SYTQDL...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176972
Q9UBC3-65-unknown	SYTQDL...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176973
Q9UBC3-65-unknown	SYTQDL...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176969
Q9UBC3-65-	SYTQDL...	65		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UBC3-209-unknown	SGDGDS...	209	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13490
Q9UBC3-209-unknown	SGDGDS...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144015
Q9UBC3-209-unknown	SGDGDS...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145424
Q9UBC3-209-unknown	SGDGDS...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146902
Q9UBC3-209-unknown	SGDGDS...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146903
Q9UBC3-209-unknown	SGDGDS...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146904
Q9UBC3-209-unknown	SGDGDS...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146906
Q9UBC3-209-unknown	SGDGDS...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147398

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QVEADS	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13490
...QVEADS	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127259
...QVEADS	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128717
...QVEADS	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130233
...QVEADS	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130234
...QVEADS	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130235
...QVEADS	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130237
...QVEADS	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130745
...YFACE	853	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YFACE	853	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68700
...YFACE	853	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68701
...YFACE	853	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68696
...YFACE	853	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68695
...YFACE	853	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68699

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	208	EADS.\|.SGDG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)