Q9UKL0: REST corepressor 1

General Information

Protein names	- REST corepressor 1 - Protein CoREST
Gene names	RCOR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UKL0

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPAMVEKGPE VSGKRRGRNN AAASASAAAA SAAASAACAS PAATAASGAA ASSASAAAAS
        70         80         90        100        110        120
AAAAPNNGQN KSLAAAAPNG NSSSNSWEEG SSGSSSDEEH GGGGMRVGPQ YQAVVPDFDP
       130        140        150        160        170        180
AKLARRSQER DNLGMLVWSP NQNLSEAKLD EYIAIAKEKH GYNMEQALGM LFWHKHNIEK
       190        200        210        220        230        240
SLADLPNFTP FPDEWTVEDK VLFEQAFSFH GKTFHRIQQM LPDKSIASLV KFYYSWKKTR
       250        260        270        280        290        300
TKTSVMDRHA RKQKREREES EDELEEANGN NPIDIEVDQN KESKKEVPPT ETVPQVKKEK
       310        320        330        340        350        360
HSTQAKNRAK RKPPKGMFLS QEDVEAVSAN ATAATTVLRQ LDMELVSVKR QIQNIKQTNS
       370        380        390        400        410        420
ALKEKLDGGI EPYRLPEVIQ KCNARWTTEE QLLAVQAIRK YGRDFQAISD VIGNKSVVQV
       430        440        450        460        470        480
KNFFVNYRRR FNIDEVLQEW EAEHGKEETN GPSNQKPVKS PDNSIKMPEE EDEAPVLDVR

YASAS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UKL0-1-unknown	MPAMVE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UKL0-2-	PAMVEK...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9UKL0-2-	PAMVEK...	2		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9UKL0-2-	PAMVEK...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UKL0-2-unknown	PAMVEK...	2		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9UKL0-2-unknown	PAMVEK...	2		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9UKL0-2-unknown	PAMVEK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UKL0-2-unknown	PAMVEK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UKL0-115-unknown	VPDFDP...	115	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13537
Q9UKL0-328-unknown	SANATA...	328	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13538
Q9UKL0-461-	PDNSIK...	461		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9UKL0-461-	PDNSIK...	461		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9UKL0-461-	PDNSIK...	461		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QYQAVV	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13537
...DVEAVS	327	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13538
...DVRYAS	482	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	114	QAVV.\|.VPDF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	327	EAVS.\|.SANA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)