Q9ULW0: Targeting protein for Xklp2

General Information

Protein names	- Targeting protein for Xklp2 - Differentially expressed in cancerous and non-cancerous lung cells 2 - DIL-2 - Hepatocellular carcinoma-associated antigen 519 - Hepatocellular carcinoma-associated antigen 90 - Protein fls353 - Restricted expression proliferation-associated protein 100 - p100
Gene names	TPX2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9ULW0

7 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSQVKSSYSY DAPSDFINFS SLDDEGDTQN IDSWFEEKAN LENKLLGKNG TGGLFQGKTP
        70         80         90        100        110        120
LRKANLQQAI VTPLKPVDNT YYKEAEKENL VEQSIPSNAC SSLEVEAAIS RKTPAQPQRR
       130        140        150        160        170        180
SLRLSAQKDL EQKEKHHVKM KAKRCATPVI IDEILPSKKM KVSNNKKKPE EEGSAHQDTA
       190        200        210        220        230        240
EKNASSPEKA KGRHTVPCMP PAKQKFLKST EEQELEKSMK MQQEVVEMRK KNEEFKKLAL
       250        260        270        280        290        300
AGIGQPVKKS VSQVTKSVDF HFRTDERIKQ HPKNQEEYKE VNFTSELRKH PSSPARVTKG
       310        320        330        340        350        360
CTIVKPFNLS QGKKRTFDET VSTYVPLAQQ VEDFHKRTPN RYHLRSKKDD INLLPSKSSV
       370        380        390        400        410        420
TKICRDPQTP VLQTKHRARA VTCKSTAELE AEELEKLQQY KFKARELDPR ILEGGPILPK
       430        440        450        460        470        480
KPPVKPPTEP IGFDLEIEKR IQERESKKKT EDEHFEFHSR PCPTKILEDV VGVPEKKVLP
       490        500        510        520        530        540
ITVPKSPAFA LKNRIRMPTK EDEEEDEPVV IKAQPVPHYG VPFKPQIPEA RTVEICPFSF
       550        560        570        580        590        600
DSRDKERQLQ KEKKIKELQK GEVPKFKALP LPHFDTINLP EKKVKNVTQI EPFCLETDRR
       610        620        630        640        650        660
GALKAQTWKH QLEEELRQQK EAACFKARPN TVISQEPFVP KKEKKSVAEG LSGSLVQEPF
       670        680        690        700        710        720
QLATEKRAKE RQELEKRMAE VEAQKAQQLE EARLQEEEQK KEELARLRRE LVHKANPIRK
       730        740
YQGLEIKSSD QPLTVPVSPK FSTRFHC

Isoforms

- Isoform 2 of Targeting protein for Xklp2

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9ULW0-1-unknown	MSQVKS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9ULW0-257-	SVDFHF...	257		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9ULW0-257-	SVDFHF...	257		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9ULW0-435-unknown	LEIEKR...	435	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13544
Q9ULW0-520-	GVPFKP...	520		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9ULW0-652-unknown	SGSLVQ...	652	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15117
Q9ULW0-653-	GSLVQE...	653		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9ULW0-654-	SLVQEP...	654		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PIGFDL	434	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13544
...VAEGLS	651	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15117
...TRFHC	747	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	434	GFDL.\|.LEIE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	651	EGLS.\|.SGSL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)