Q9UNX4: WD repeat-containing protein 3

General Information

Protein names	- WD repeat-containing protein 3
Gene names	WDR3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UNX4

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGLTKQYLRY VASAVFGVIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW DLRKGEKILI
        70         80         90        100        110        120
LQGLKQEVTC LCPSPDGLHL AVGYEDGSIR IFSLLSGEGN VTFNGHKAAI TTLKYDQLGG
       130        140        150        160        170        180
RLASGSKDTD IIVWDVINES GLYRLKGHKD AITQALFLRE KNLLVTSGKD TMVKWWDLDT
       190        200        210        220        230        240
QHCFKTMVGH RTEVWGLVLL SEEKRLITGA SDSELRVWDI AYLQEIEDPE EPDPKKIKGS
       250        260        270        280        290        300
SPGIQDTLEA EDGAFETDEA PEDRILSCRK AGSIMREGRD RVVNLAVDKT GRILACHGTD
       310        320        330        340        350        360
SVLELFCILS KKEIQKKMDK KMKKARKKAK LHSSKGEEED PEVNVEMSLQ DEIQRVTNIK
       370        380        390        400        410        420
TSAKIKSFDL IHSPHGELKA VFLLQNNLVE LYSLNPSLPT PQPVRTSRIT IGGHRSDVRT
       430        440        450        460        470        480
LSFSSDNIAV LSAAADSIKI WNRSTLQCIR TMTCEYALCS FFVPGDRQVV IGTKTGKLQL
       490        500        510        520        530        540
YDLASGNLLE TIDAHDGALW SMSLSPDQRG FVTGGADKSV KFWDFELVKD ENSTQKRLSV
       550        560        570        580        590        600
KQTRTLQLDE DVLCVSYSPN QKLLAVSLLD CTVKIFYVDT LKFFLSLYGH KLPVICMDIS
       610        620        630        640        650        660
HDGALIATGS ADRNVKIWGL DFGDCHKSLF AHDDSVMYLQ FVPKSHLFFT AGKDHKIKQW
       670        680        690        700        710        720
DADKFEHIQT LEGHHQEIWC LAVSPSGDYV VSSSHDKSLR LWERTREPLI LEEEREMERE
       730        740        750        760        770        780
AEYEESVAKE DQPAVPGETQ GDSYFTGKKT IETVKAAERI MEAIELYREE TAKMKEHKAI
       790        800        810        820        830        840
CKAAGKEVPL PSNPILMAYG SISPSAYVLE IFKGIKSSEL EESLLVLPFS YVPDILKLFN
       850        860        870        880        890        900
EFIQLGSDVE LICRCLFFLL RIHFGQITSN QMLVPVIEKL RETTISKVSQ VRDVIGFNMA
       910        920        930        940
GLDYLKRECE AKSEVMFFAD ATSHLEEKKR KRKKREKLIL TLT

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UNX4-1-unknown	MGLTKQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UNX4-2-unknown	GLTKQY...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UNX4-2-unknown	GLTKQY...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UNX4-249-unknown	EAEDGA...	249	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15126
Q9UNX4-253-	GAFETD...	253		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UNX4-505-	SPDQRG...	505		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UNX4-743-unknown	SYFTGK...	743	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13553

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...IQDTLE	248	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15126
...ETQGDS	742	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13553
...ILTLT	943	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...ILTLT	943		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	248	DTLE.\|.EAED	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	742	QGDS.\|.SYFT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)