Q9UPN4: Centrosomal protein of 131 kDa

General Information

Protein names	- Centrosomal protein of 131 kDa - 5-azacytidine-induced protein 1 - Pre-acrosome localization protein 1
Gene names	CEP131
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UPN4

7 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Centrosomal protein of 131 kDa - Isoform 3 of Centrosomal protein of 131 kDa

Sequence View

        10         20         30         40         50         60
MKGTRAIGSV PERSPAGVDL SLTGLPPPVS RRPGSAATTK PIVRSVSVVT GSEQKRKVLE
        70         80         90        100        110        120
ATGPGGSQAI NNLRRSNSTT QVSQPRSGSP RPTEPTDFLM LFEGSPSGKK RPASLSTAPS
       130        140        150        160        170        180
EKGATWNVLD DQPRGFTLPS NARSSSALDS PAGPRRKECT VALAPNFTAN NRSNKGAVGN
       190        200        210        220        230        240
CVTTMVHNRY TPSERAPPLK SSNQTAPSLN NIIKAATCEG SESSGFGKLP KNVSSATHSA
       250        260        270        280        290        300
RNNTGGSTGL PRRKEVTEEE AERFIHQVNQ ATVTIQRWYR HQVQRRGAGA ARLEHLLQAK
       310        320        330        340        350        360
REEQRQRSGE GTLLDLHQQK EAARRKAREE KARQARRAAI QELQQKRALR AQKASTAERG
       370        380        390        400        410        420
PPENPRETRV PGMRQPAQEL SPTPGGTAHQ ALKANNTGGG LPAAGPGDRC LPTSDSSPEP
       430        440        450        460        470        480
QQPPEDRTQD VLAQDAAGDN LEMMAPSRGS AKSRGPLEEL LHTLQLLEKE PDVLPRPRTH
       490        500        510        520        530        540
HRGRYAWASE VTTEDDASSL TADNLEKFGK LSAFPEPPED GTLLSEAKLQ SIMSFLDEME
       550        560        570        580        590        600
KSGQDQLDSQ QEGWVPEAGP GPLELGSEVS TSVMRLKLEV EEKKQAMLLL QRALAQQRDL
       610        620        630        640        650        660
TARRVKETEK ALSRQLQRQR EHYEATIQRH LAFIDQLIED KKVLSEKCEA VVAELKQEDQ
       670        680        690        700        710        720
RCTERVAQAQ AQHELEIKKL KELMSATEKA RREKWISEKT KKIKEVTVRG LEPEIQKLIA
       730        740        750        760        770        780
RHKQEVRRLK SLHEAELLQS DERASQRCLR QAEELREQLE REKEALGQQE RERARQRFQQ
       790        800        810        820        830        840
HLEQEQWALQ QQRQRLYSEV AEERERLGQQ AARQRAELEE LRQQLEESSS ALTRALRAEF
       850        860        870        880        890        900
EKGREEQERR HQMELNTLKQ QLELERQAWE AGRTRKEEAW LLNREQELRE EIRKGRDKEI
       910        920        930        940        950        960
ELVIHRLEAD MALAKEESEK AAESRIKRLR DKYEAELSEL EQSERKLQER CSELKGQLGE
       970        980        990       1000       1010       1020
AEGENLRLQG LVRQKERALE DAQAVNEQLS SERSNLAQVI RQEFEDRLAA SEEETRQAKA
      1030       1040       1050       1060       1070       1080
ELATLQARQQ LELEEVHRRV KTALARKEEA VSSLRTQHEA AVKRADHLEE LLEQHRRPTP

STK         10         20         30         40         50         60
MKGTRAIGSV PERSPAGVDL SLTGLPPPVS RRPGSAATTK PIVRSVSVVT GSEQKRKVLE
        70         80         90        100        110        120
ATGPGGSQAI NNLRRSNSTT QVSQPRSGSP RPTEPTDFLM LFEGSPSGKK RPASLSTAPS
       130        140        150        160        170        180
EKGATWNVLD DQPRGFTLPS NARSSSALDS PAGPRRKECT VALAPNFTAN NRSNKGAVGN
       190        200        210        220        230        240
CVTTMVHNRY TPSERAPPLK SSNQTAPSLN NIIKAATCEG SESSGFGKLP KNVSSATHSA
       250        260        270        280        290        300
RNNTGGSTGL PRRKEVTEEE AERFIHQVNQ ATVTIQRWYR HQVQRRGAGA ARLEHLLQAK
       310        320        330        340        350        360
REEQRQRSGE GTLLDLHQQK EAARRKAREE KARQARRAAI QELQQKRALR AQKASTAERG
       370        380        390        400        410        420
PPENPRETRV PGMRQPAQEL SPTPGGTAHQ ALKANNTGGG LPAAGPGDRC LPTSDSSPEP
       430        440        450        460        470        480
QQPPEDRTQD VLAQDAAGDN LEMMAPSRGS AKSRGPLEEL LHTLQLLEKE PDVLPRPRTH
       490        500        510        520        530        540
HRGRYAWASE VTTEDDASSL TADNLEKFGK LSAFPEPPED GTLLSEAKLQ SIMSFLDEME
       550        560        570        580        590        600
KSGQDQLDSQ QEGWVPEAGP GPLELGSEVS TSVMRLKLEV EEKKQAMLLL QRALAQQRDL
       610        620        630        640        650        660
TARRVKETEK ALSRQLQRQR EHYEATIQRH LAFIDQLIED KKVLSEKCEA VVAELKQEDQ
       670        680        690        700        710        720
RCTERVAQAQ AQHELEIKKL KELMSATEKA RREKWISEKT KKIKEVTVRG LEPEIQKLIA
       730        740        750        760        770        780
RHKQEVRRLK SLHEAELLQS DERASQRCLR QAEELREQLE REKEALGQQE RERARQRFQQ
       790        800        810        820        830        840
HLEQEQWALQ QQRQRLYSEV AEERERLGQQ AARQRAELEE LRQQLEESSS ALTRALRAEF
       850        860        870        880        890        900
EKGREEQERR HQMELNTLKQ QLELERQAWE AGRTRKEEAW LLNREQELRE EIRKGRDKEI
       910        920        930        940        950        960
ELVIHRLEAD MALAKEESEK AAESRIKRLR DKYEAELSEL EQSERKLQER CSELKGQLGE
       970        980        990       1000       1010       1020
AEGENLRLQG LVRQKERALE DAQAVNEQLS SERSNLAQVI RQEFEDRLAA SEEETRQAKA
      1030       1040       1050       1060       1070       1080
ELATLQARQQ LELEEVHRRV KTALARKEEA VSSLRTQHEA AVKRADHLEE LLEQHRRPTP

STK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UPN4-1-unknown	MKGTRA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UPN4-1-unknown	MKGTRA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71502
Q9UPN4-1-unknown	MKGTRA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71503
Q9UPN4-100-unknown	MLFEGS...	100		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9UPN4-100-unknown	MLFEGS...	100	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161306
Q9UPN4-100-unknown	MLFEGS...	100	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161307
Q9UPN4-100-	MLFEGS...	100		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9UPN4-440-unknown	NLEMMA...	440	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13559
Q9UPN4-440-unknown	NLEMMA...	440	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152645
Q9UPN4-440-unknown	NLEMMA...	440	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152646
Q9UPN4-549-unknown	SQQEGW...	549	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171215
Q9UPN4-549-unknown	SQQEGW...	549	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171216
Q9UPN4-549-	SQQEGW...	549		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UPN4-912-unknown	ALAKEE...	912	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13562
Q9UPN4-912-unknown	ALAKEE...	912	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156761
Q9UPN4-912-unknown	ALAKEE...	912	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156937

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DAAGDN	439	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13559
...DAAGDN	439	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136063
...DAAGDN	439	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136064
...LEADMA	911	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13562
...LEADMA	911	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140251
...LEADMA	911	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140425
...TPSTK	1083	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TPSTK	1083	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67121
...TPSTK	1083	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67120

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	439	AGDN.\|.NLEM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	911	ADMA.\|.ALAK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)