Q9UPQ9: Trinucleotide repeat-containing gene 6B protein
| Protein names | - Trinucleotide repeat-containing gene 6B protein |
|---|---|
| Gene names | TNRC6B |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q9UPQ9 |
3
N-termini
5
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MREKEQEREE QLMEDKKRKK EDKKKKEATQ KVTEQKTKVP EVTKPSLSQP TAASPIGSSP
70 80 90 100 110 120
SPPVNGGNNA KRVAVPNGQP PSAARYMPRE VPPRFRCQQD HKVLLKRGQP PPPSCMLLGG
130 140 150 160 170 180
GAGPPPCTAP GANPNNAQVT GALLQSESGT APDSTLGGAA ASNYANSTWG SGASSNNGTS
190 200 210 220 230 240
PNPIHIWDKV IVDGSDMEEW PCIASKDTES SSENTTDNNS ASNPGSEKST LPGSTTSNKG
250 260 270 280 290 300
KGSQCQSASS GNECNLGVWK SDPKAKSVQS SNSTTENNNG LGNWRNVSGQ DRIGPGSGFS
310 320 330 340 350 360
NFNPNSNPSA WPALVQEGTS RKGALETDNS NSSAQVSTVG QTSREQQSKM ENAGVNFVVS
370 380 390 400 410 420
GREQAQIHNT DGPKNGNTNS LNLSSPNPME NKGMPFGMGL GNTSRSTDAP SQSTGDRKTG
430 440 450 460 470 480
SVGSWGAARG PSGTDTVSGQ SNSGNNGNNG KEREDSWKGA SVQKSTGSKN DSWDNNNRST
490 500 510 520 530 540
GGSWNFGPQD SNDNKWGEGN KMTSGVSQGE WKQPTGSDEL KIGEWSGPNQ PNSSTGAWDN
550 560 570 580 590 600
QKGHPLPENQ GNAQAPCWGR SSSSTGSEVG GQSTGSNHKA GSSDSHNSGR RSYRPTHPDC
610 620 630 640 650 660
QAVLQTLLSR TDLDPRVLSN TGWGQTQIKQ DTVWDIEEVP RPEGKSDKGT EGWESAATQT
670 680 690 700 710 720
KNSGGWGDAP SQSNQMKSGW GELSASTEWK DPKNTGGWND YKNNNSSNWG GGRPDEKTPS
730 740 750 760 770 780
SWNENPSKDQ GWGGGRQPNQ GWSSGKNGWG EEVDQTKNSN WESSASKPVS GWGEGGQNEI
790 800 810 820 830 840
GTWGNGGNAS LASKGGWEDC KRSPAWNETG RQPNSWNKQH QQQQPPQQPP PPQPEASGSW
850 860 870 880 890 900
GGPPPPPPGN VRPSNSSWSS GPQPATPKDE EPSGWEEPSP QSISRKMDID DGTSAWGDPN
910 920 930 940 950 960
SYNYKNVNLW DKNSQGGPAP REPNLPTPMT SKSASVWSKS TPPAPDNGTS AWGEPNESSP
970 980 990 1000 1010 1020
GWGEMDDTGA STTGWGNTPA NAPNAMKPNS KSMQDGWGES DGPVTGARHP SWEEEEDGGV
1030 1040 1050 1060 1070 1080
WNTTGSQGSA SSHNSASWGQ GGKKQMKCSL KGGNNDSWMN PLAKQFSNMG LLSQTEDNPS
1090 1100 1110 1120 1130 1140
SKMDLSVGSL SDKKFDVDKR AMNLGDFNDI MRKDRSGFRP PNSKDMGTTD SGPYFEKLTL
1150 1160 1170 1180 1190 1200
PFSNQDGCLG DEAPCSPFSP SPSYKLSPSG STLPNVSLGA IGTGLNPQNF AARQGGSHGL
1210 1220 1230 1240 1250 1260
FGNSTAQSRG LHTPVQPLNS SPSLRAQVPP QFISPQVSAS MLKQFPNSGL SPGLFNVGPQ
1270 1280 1290 1300 1310 1320
LSPQQIAMLS QLPQIPQFQL ACQLLLQQQQ QQQLLQNQRK ISQAVRQQQE QQLARMVSAL
1330 1340 1350 1360 1370 1380
QQQQQQQQRQ PGMKHSPSHP VGPKPHLDNM VPNALNVGLP DLQTKGPIPG YGSGFSSGGM
1390 1400 1410 1420 1430 1440
DYGMVGGKEA GTESRFKQWT SMMEGLPSVA TQEANMHKNG AIVAPGKTRG GSPYNQFDII
1450 1460 1470 1480 1490 1500
PGDTLGGHTG PAGDSWLPAK SPPTNKIGSK SSNASWPPEF QPGVPWKGIQ NIDPESDPYV
1510 1520 1530 1540 1550 1560
TPGSVLGGTA TSPIVDTDHQ LLRDNTTGSN SSLNTSLPSP GAWPYSASDN SFTNVHSTSA
1570 1580 1590 1600 1610 1620
KFPDYKSTWS PDPIGHNPTH LSNKMWKNHI SSRNTTPLPR PPPGLTNPKP SSPWSSTAPR
1630 1640 1650 1660 1670 1680
SVRGWGTQDS RLASASTWSD GGSVRPSYWL VLHNLTPQID GSTLRTICMQ HGPLLTFHLN
1690 1700 1710 1720 1730 1740
LTQGTALIRY STKQEAAKAQ TALHMCVLGN TTILAEFATD DEVSRFLAQA QPPTPAATPS
1750 1760 1770 1780 1790 1800
APAAGWQSLE TGQNQSDPVG PALNLFGGST GLGQWSSSAG GSSGADLAGA SLWGPPNYSS
1810 1820 1830
SLWGVPTVED PHRMGSPAPL LPGDLLGGGS DSI
Isoforms
- Isoform 2 of Trinucleotide repeat-containing gene 6B protein - Isoform 3 of Trinucleotide repeat-containing gene 6B proteinSequence View
10 20 30 40 50 60
MREKEQEREE QLMEDKKRKK EDKKKKEATQ KVTEQKTKVP EVTKPSLSQP TAASPIGSSP
70 80 90 100 110 120
SPPVNGGNNA KRVAVPNGQP PSAARYMPRE VPPRFRCQQD HKVLLKRGQP PPPSCMLLGG
130 140 150 160 170 180
GAGPPPCTAP GANPNNAQVT GALLQSESGT APDSTLGGAA ASNYANSTWG SGASSNNGTS
190 200 210 220 230 240
PNPIHIWDKV IVDGSDMEEW PCIASKDTES SSENTTDNNS ASNPGSEKST LPGSTTSNKG
250 260 270 280 290 300
KGSQCQSASS GNECNLGVWK SDPKAKSVQS SNSTTENNNG LGNWRNVSGQ DRIGPGSGFS
310 320 330 340 350 360
NFNPNSNPSA WPALVQEGTS RKGALETDNS NSSAQVSTVG QTSREQQSKM ENAGVNFVVS
370 380 390 400 410 420
GREQAQIHNT DGPKNGNTNS LNLSSPNPME NKGMPFGMGL GNTSRSTDAP SQSTGDRKTG
430 440 450 460 470 480
SVGSWGAARG PSGTDTVSGQ SNSGNNGNNG KEREDSWKGA SVQKSTGSKN DSWDNNNRST
490 500 510 520 530 540
GGSWNFGPQD SNDNKWGEGN KMTSGVSQGE WKQPTGSDEL KIGEWSGPNQ PNSSTGAWDN
550 560 570 580 590 600
QKGHPLPENQ GNAQAPCWGR SSSSTGSEVG GQSTGSNHKA GSSDSHNSGR RSYRPTHPDC
610 620 630 640 650 660
QAVLQTLLSR TDLDPRVLSN TGWGQTQIKQ DTVWDIEEVP RPEGKSDKGT EGWESAATQT
670 680 690 700 710 720
KNSGGWGDAP SQSNQMKSGW GELSASTEWK DPKNTGGWND YKNNNSSNWG GGRPDEKTPS
730 740 750 760 770 780
SWNENPSKDQ GWGGGRQPNQ GWSSGKNGWG EEVDQTKNSN WESSASKPVS GWGEGGQNEI
790 800 810 820 830 840
GTWGNGGNAS LASKGGWEDC KRSPAWNETG RQPNSWNKQH QQQQPPQQPP PPQPEASGSW
850 860 870 880 890 900
GGPPPPPPGN VRPSNSSWSS GPQPATPKDE EPSGWEEPSP QSISRKMDID DGTSAWGDPN
910 920 930 940 950 960
SYNYKNVNLW DKNSQGGPAP REPNLPTPMT SKSASVWSKS TPPAPDNGTS AWGEPNESSP
970 980 990 1000 1010 1020
GWGEMDDTGA STTGWGNTPA NAPNAMKPNS KSMQDGWGES DGPVTGARHP SWEEEEDGGV
1030 1040 1050 1060 1070 1080
WNTTGSQGSA SSHNSASWGQ GGKKQMKCSL KGGNNDSWMN PLAKQFSNMG LLSQTEDNPS
1090 1100 1110 1120 1130 1140
SKMDLSVGSL SDKKFDVDKR AMNLGDFNDI MRKDRSGFRP PNSKDMGTTD SGPYFEKLTL
1150 1160 1170 1180 1190 1200
PFSNQDGCLG DEAPCSPFSP SPSYKLSPSG STLPNVSLGA IGTGLNPQNF AARQGGSHGL
1210 1220 1230 1240 1250 1260
FGNSTAQSRG LHTPVQPLNS SPSLRAQVPP QFISPQVSAS MLKQFPNSGL SPGLFNVGPQ
1270 1280 1290 1300 1310 1320
LSPQQIAMLS QLPQIPQFQL ACQLLLQQQQ QQQLLQNQRK ISQAVRQQQE QQLARMVSAL
1330 1340 1350 1360 1370 1380
QQQQQQQQRQ PGMKHSPSHP VGPKPHLDNM VPNALNVGLP DLQTKGPIPG YGSGFSSGGM
1390 1400 1410 1420 1430 1440
DYGMVGGKEA GTESRFKQWT SMMEGLPSVA TQEANMHKNG AIVAPGKTRG GSPYNQFDII
1450 1460 1470 1480 1490 1500
PGDTLGGHTG PAGDSWLPAK SPPTNKIGSK SSNASWPPEF QPGVPWKGIQ NIDPESDPYV
1510 1520 1530 1540 1550 1560
TPGSVLGGTA TSPIVDTDHQ LLRDNTTGSN SSLNTSLPSP GAWPYSASDN SFTNVHSTSA
1570 1580 1590 1600 1610 1620
KFPDYKSTWS PDPIGHNPTH LSNKMWKNHI SSRNTTPLPR PPPGLTNPKP SSPWSSTAPR
1630 1640 1650 1660 1670 1680
SVRGWGTQDS RLASASTWSD GGSVRPSYWL VLHNLTPQID GSTLRTICMQ HGPLLTFHLN
1690 1700 1710 1720 1730 1740
LTQGTALIRY STKQEAAKAQ TALHMCVLGN TTILAEFATD DEVSRFLAQA QPPTPAATPS
1750 1760 1770 1780 1790 1800
APAAGWQSLE TGQNQSDPVG PALNLFGGST GLGQWSSSAG GSSGADLAGA SLWGPPNYSS
1810 1820 1830
SLWGVPTVED PHRMGSPAPL LPGDLLGGGS DSI
10 20 30 40 50 60
MREKEQEREE QLMEDKKRKK EDKKKKEATQ KVTEQKTKVP EVTKPSLSQP TAASPIGSSP
70 80 90 100 110 120
SPPVNGGNNA KRVAVPNGQP PSAARYMPRE VPPRFRCQQD HKVLLKRGQP PPPSCMLLGG
130 140 150 160 170 180
GAGPPPCTAP GANPNNAQVT GALLQSESGT APDSTLGGAA ASNYANSTWG SGASSNNGTS
190 200 210 220 230 240
PNPIHIWDKV IVDGSDMEEW PCIASKDTES SSENTTDNNS ASNPGSEKST LPGSTTSNKG
250 260 270 280 290 300
KGSQCQSASS GNECNLGVWK SDPKAKSVQS SNSTTENNNG LGNWRNVSGQ DRIGPGSGFS
310 320 330 340 350 360
NFNPNSNPSA WPALVQEGTS RKGALETDNS NSSAQVSTVG QTSREQQSKM ENAGVNFVVS
370 380 390 400 410 420
GREQAQIHNT DGPKNGNTNS LNLSSPNPME NKGMPFGMGL GNTSRSTDAP SQSTGDRKTG
430 440 450 460 470 480
SVGSWGAARG PSGTDTVSGQ SNSGNNGNNG KEREDSWKGA SVQKSTGSKN DSWDNNNRST
490 500 510 520 530 540
GGSWNFGPQD SNDNKWGEGN KMTSGVSQGE WKQPTGSDEL KIGEWSGPNQ PNSSTGAWDN
550 560 570 580 590 600
QKGHPLPENQ GNAQAPCWGR SSSSTGSEVG GQSTGSNHKA GSSDSHNSGR RSYRPTHPDC
610 620 630 640 650 660
QAVLQTLLSR TDLDPRVLSN TGWGQTQIKQ DTVWDIEEVP RPEGKSDKGT EGWESAATQT
670 680 690 700 710 720
KNSGGWGDAP SQSNQMKSGW GELSASTEWK DPKNTGGWND YKNNNSSNWG GGRPDEKTPS
730 740 750 760 770 780
SWNENPSKDQ GWGGGRQPNQ GWSSGKNGWG EEVDQTKNSN WESSASKPVS GWGEGGQNEI
790 800 810 820 830 840
GTWGNGGNAS LASKGGWEDC KRSPAWNETG RQPNSWNKQH QQQQPPQQPP PPQPEASGSW
850 860 870 880 890 900
GGPPPPPPGN VRPSNSSWSS GPQPATPKDE EPSGWEEPSP QSISRKMDID DGTSAWGDPN
910 920 930 940 950 960
SYNYKNVNLW DKNSQGGPAP REPNLPTPMT SKSASVWSKS TPPAPDNGTS AWGEPNESSP
970 980 990 1000 1010 1020
GWGEMDDTGA STTGWGNTPA NAPNAMKPNS KSMQDGWGES DGPVTGARHP SWEEEEDGGV
1030 1040 1050 1060 1070 1080
WNTTGSQGSA SSHNSASWGQ GGKKQMKCSL KGGNNDSWMN PLAKQFSNMG LLSQTEDNPS
1090 1100 1110 1120 1130 1140
SKMDLSVGSL SDKKFDVDKR AMNLGDFNDI MRKDRSGFRP PNSKDMGTTD SGPYFEKLTL
1150 1160 1170 1180 1190 1200
PFSNQDGCLG DEAPCSPFSP SPSYKLSPSG STLPNVSLGA IGTGLNPQNF AARQGGSHGL
1210 1220 1230 1240 1250 1260
FGNSTAQSRG LHTPVQPLNS SPSLRAQVPP QFISPQVSAS MLKQFPNSGL SPGLFNVGPQ
1270 1280 1290 1300 1310 1320
LSPQQIAMLS QLPQIPQFQL ACQLLLQQQQ QQQLLQNQRK ISQAVRQQQE QQLARMVSAL
1330 1340 1350 1360 1370 1380
QQQQQQQQRQ PGMKHSPSHP VGPKPHLDNM VPNALNVGLP DLQTKGPIPG YGSGFSSGGM
1390 1400 1410 1420 1430 1440
DYGMVGGKEA GTESRFKQWT SMMEGLPSVA TQEANMHKNG AIVAPGKTRG GSPYNQFDII
1450 1460 1470 1480 1490 1500
PGDTLGGHTG PAGDSWLPAK SPPTNKIGSK SSNASWPPEF QPGVPWKGIQ NIDPESDPYV
1510 1520 1530 1540 1550 1560
TPGSVLGGTA TSPIVDTDHQ LLRDNTTGSN SSLNTSLPSP GAWPYSASDN SFTNVHSTSA
1570 1580 1590 1600 1610 1620
KFPDYKSTWS PDPIGHNPTH LSNKMWKNHI SSRNTTPLPR PPPGLTNPKP SSPWSSTAPR
1630 1640 1650 1660 1670 1680
SVRGWGTQDS RLASASTWSD GGSVRPSYWL VLHNLTPQID GSTLRTICMQ HGPLLTFHLN
1690 1700 1710 1720 1730 1740
LTQGTALIRY STKQEAAKAQ TALHMCVLGN TTILAEFATD DEVSRFLAQA QPPTPAATPS
1750 1760 1770 1780 1790 1800
APAAGWQSLE TGQNQSDPVG PALNLFGGST GLGQWSSSAG GSSGADLAGA SLWGPPNYSS
1810 1820 1830
SLWGVPTVED PHRMGSPAPL LPGDLLGGGS DSI
Protein Neighborhood
Domains & Features
3 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q9UPQ9-1-unknown | MREKEQ... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q9UPQ9-632-unknown | TVWDIE... | 632 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13570 | |||
| Q9UPQ9-1086-unknown | SVGSLS... | 1086 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15144 | |||
| Q9UPQ9-1086-unknown | SVGSLS... | 1086 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt150698 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...QIKQDT | 631 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13570 | |||
| ...SKMDLS | 1085 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15144 | |||
| ...SKMDLS | 1085 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt134096 | |||
| ...TDDEVS | 1723 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, | |||
| ...TDDEVS | 1723 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
| ...TDDEVS | 1723 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, | |||
| ...TDDEVS | 1723 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt143918 | |||
| ...GSDSI | 1833 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...GSDSI | 1833 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt88348 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| GRAB_HUMAN | 631 | KQDT.|.TVWD | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
| GRAM_HUMAN | 1085 | MDLS.|.SVGS | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|