Q9Y2X7: ARF GTPase-activating protein GIT1

General Information

Protein names	- ARF GTPase-activating protein GIT1 - ARF GAP GIT1 - Cool-associated and tyrosine-phosphorylated protein 1 - CAT-1 - CAT1 - G protein-coupled receptor kinase-interactor 1 - GRK-interacting protein 1
Gene names	GIT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y2X7

9 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of ARF GTPase-activating protein GIT1 - Isoform 3 of ARF GTPase-activating protein GIT1

Sequence View

        10         20         30         40         50         60
MSRKGPRAEV CADCSAPDPG WASISRGVLV CDECCSVHRS LGRHISIVKH LRHSAWPPTL
        70         80         90        100        110        120
LQMVHTLASN GANSIWEHSL LDPAQVQSGR RKANPQDKVH PIKSEFIRAK YQMLAFVHKL
       130        140        150        160        170        180
PCRDDDGVTA KDLSKQLHSS VRTGNLETCL RLLSLGAQAN FFHPEKGTTP LHVAAKAGQT
       190        200        210        220        230        240
LQAELLVVYG ADPGSPDVNG RTPIDYARQA GHHELAERLV ECQYELTDRL AFYLCGRKPD
       250        260        270        280        290        300
HKNGHYIIPQ MADSLDLSEL AKAAKKKLQA LSNRLFEELA MDVYDEVDRR ENDAVWLATQ
       310        320        330        340        350        360
NHSTLVTERS AVPFLPVNPE YSATRNQGRQ KLARFNAREF ATLIIDILSE AKRRQQGKSL
       370        380        390        400        410        420
SSPTDNLELS LRSQSDLDDQ HDYDSVASDE DTDQEPLRST GATRSNRARS MDSSDLSDGA
       430        440        450        460        470        480
VTLQEYLELK KALATSEAKV QQLMKVNSSL SDELRRLQRE IHKLQAENLQ LRQPPGPVPT
       490        500        510        520        530        540
PPLPSERAEH TPMAPGGSTH RRDRQAFSMY EPGSALKPFG GPPGDELTTR LQPFHSTELE
       550        560        570        580        590        600
DDAIYSVHVP AGLYRIRKGV SASAVPFTPS SPLLSCSQEG SRHTSKLSRH GSGADSDYEN
       610        620        630        640        650        660
TQSGDPLLGL EGKRFLELGK EEDFHPELES LDGDLDPGLP STEDVILKTE QVTKNIQELL
       670        680        690        700        710        720
RAAQEFKHDS FVPCSEKIHL AVTEMASLFP KRPALEPVRS SLRLLNASAY RLQSECRKTV
       730        740        750        760
PPEPGAPVDF QLLTQQVIQC AYDIAKAAKQ LVTITTREKK Q         10         20         30         40         50         60
MSRKGPRAEV CADCSAPDPG WASISRGVLV CDECCSVHRS LGRHISIVKH LRHSAWPPTL
        70         80         90        100        110        120
LQMVHTLASN GANSIWEHSL LDPAQVQSGR RKANPQDKVH PIKSEFIRAK YQMLAFVHKL
       130        140        150        160        170        180
PCRDDDGVTA KDLSKQLHSS VRTGNLETCL RLLSLGAQAN FFHPEKGTTP LHVAAKAGQT
       190        200        210        220        230        240
LQAELLVVYG ADPGSPDVNG RTPIDYARQA GHHELAERLV ECQYELTDRL AFYLCGRKPD
       250        260        270        280        290        300
HKNGHYIIPQ MADSLDLSEL AKAAKKKLQA LSNRLFEELA MDVYDEVDRR ENDAVWLATQ
       310        320        330        340        350        360
NHSTLVTERS AVPFLPVNPE YSATRNQGRQ KLARFNAREF ATLIIDILSE AKRRQQGKSL
       370        380        390        400        410        420
SSPTDNLELS LRSQSDLDDQ HDYDSVASDE DTDQEPLRST GATRSNRARS MDSSDLSDGA
       430        440        450        460        470        480
VTLQEYLELK KALATSEAKV QQLMKVNSSL SDELRRLQRE IHKLQAENLQ LRQPPGPVPT
       490        500        510        520        530        540
PPLPSERAEH TPMAPGGSTH RRDRQAFSMY EPGSALKPFG GPPGDELTTR LQPFHSTELE
       550        560        570        580        590        600
DDAIYSVHVP AGLYRIRKGV SASAVPFTPS SPLLSCSQEG SRHTSKLSRH GSGADSDYEN
       610        620        630        640        650        660
TQSGDPLLGL EGKRFLELGK EEDFHPELES LDGDLDPGLP STEDVILKTE QVTKNIQELL
       670        680        690        700        710        720
RAAQEFKHDS FVPCSEKIHL AVTEMASLFP KRPALEPVRS SLRLLNASAY RLQSECRKTV
       730        740        750        760
PPEPGAPVDF QLLTQQVIQC AYDIAKAAKQ LVTITTREKK Q

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y2X7-1-unknown	MSRKGP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y2X7-1-unknown	MSRKGP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75986
Q9Y2X7-1-unknown	MSRKGP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75987
Q9Y2X7-63-unknown	MVHTLA...	63	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464933
Q9Y2X7-63-unknown	MVHTLA...	63	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196363
Q9Y2X7-63-unknown	MVHTLA...	63	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196364
Q9Y2X7-240-unknown	DHKNGH...	240	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463543
Q9Y2X7-390-unknown	EDTDQE...	390	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13612
Q9Y2X7-390-unknown	EDTDQE...	390	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151989
Q9Y2X7-419-unknown	GAVTLQ...	419		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y2X7-419-unknown	GAVTLQ...	419	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161599
Q9Y2X7-419-	GAVTLQ...	419		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9Y2X7-419-	GAVTLQ...	419		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9Y2X7-419-	GAVTLQ...	419		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9Y2X7-538-unknown	ELEDDA...	538	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463435
Q9Y2X7-538-unknown	ELEDDA...	538	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199820
Q9Y2X7-633-unknown	GDLDPG...	633	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165274
Q9Y2X7-633-	GDLDPG...	633		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9Y2X7-633-	GDLDPG...	633		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y2X7-633-	GDLDPG...	633		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KYQMLA	114	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464933
...KYQMLA	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154518
...KYQMLA	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154519
...AQANFF	161	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466824
...AQANFF	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155113
...SVASDE	389	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13612
...SVASDE	389	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135397
...PTPPLP	483	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463543
...REKKQ	761	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...REKKQ	761	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71605

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	389	ASDE.\|.EDTD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)