Q9Y2Z4: Tyrosine--tRNA ligase, mitochondrial

General Information

Protein names	- Tyrosine--tRNA ligase, mitochondrial - 6.1.1.1 {ECO:0000269\|PubMed:15779907, ECO:0000269\|PubMed:17997975} - Tyrosyl-tRNA synthetase - TyrRS {ECO:0000303\|PubMed:17997975}
Gene names	YARS2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y2Z4

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAPILRSFS WGRWSGTLNL SVLLPLGLRK AHSGAQGLLA AQKARGLFKD FFPETGTKIE
        70         80         90        100        110        120
LPELFDRGTA SFPQTIYCGF DPTADSLHVG HLLALLGLFH LQRAGHNVIA LVGGATARLG
       130        140        150        160        170        180
DPSGRTKERE ALETERVRAN ARALRLGLEA LAANHQQLFT DGRSWGSFTV LDNSAWYQKQ
       190        200        210        220        230        240
HLVDFLAAVG GHFRMGTLLS RQSVQLRLKS PEGMSLAEFF YQVLQAYDFY YLFQRYGCRV
       250        260        270        280        290        300
QLGGSDQLGN IMSGYEFINK LTGEDVFGIT VPLITSTTGA KLGKSAGNAV WLNRDKTSPF
       310        320        330        340        350        360
ELYQFFVRQP DDSVERYLKL FTFLPLPEID HIMQLHVKEP ERRGPQKRLA AEVTKLVHGR
       370        380        390        400        410        420
EGLDSAKRCT QALYHSSIDA LEVMSDQELK ELFKEAPFSE FFLDPGTSVL DTCRKANAIP
       430        440        450        460        470
DGPRGYRMIT EGGVSINHQQ VTNPESVLIV GQHILKNGLS LLKIGKRNFY IIKWLQL

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y2Z4-17-unknown	TLNLSV...	17	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y2Z4-31-	AHSGAQ...	31		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9Y2Z4-31-	AHSGAQ...	31		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9Y2Z4-31-	AHSGAQ...	31		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9Y2Z4-31-	AHSGAQ...	31		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9Y2Z4-31-	AHSGAQ...	31		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q9Y2Z4-31-	AHSGAQ...	31		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y2Z4-31-	AHSGAQ...	31		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y2Z4-31-	AHSGAQ...	31		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y2Z4-31-	AHSGAQ...	31		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9Y2Z4-31-	AHSGAQ...	31		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9Y2Z4-31-	AHSGAQ...	31		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q9Y2Z4-31-	AHSGAQ...	31		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y2Z4-31-unknown	AHSGAQ...	31		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y2Z4-31-unknown	AHSGAQ...	31		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...KWLQL	477	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)