Q9Y314: Nitric oxide synthase-interacting protein

General Information

Protein names	- Nitric oxide synthase-interacting protein - E3 ubiquitin-protein ligase NOSIP - 2.3.2.27 - RING-type E3 ubiquitin transferase NOSIP {ECO:0000305} - eNOS-interacting protein
Gene names	NOSIP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y314

3 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP
        70         80         90        100        110        120
DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGTRREEQK ELQRAASQDH VRGFLEKESA
       130        140        150        160        170        180
IVSRPLNPFT AKALSGTSPD DVQPGPSVGP PSKDKDKVLP SFWIPSLTPE AKATKLEKPS
       190        200        210        220        230        240
RTVTCPMSGK PLRMSDLTPV HFTPLDSSVD RVGLITRSER YVCAVTRDSL SNATPCAVLR
       250        260        270        280        290        300
PSGAVVTLEC VEKLIRKDMV DPVTGDKLTD RDIIVLQRGG TGFAGSGVKL QAEKSRPVMQ

A

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y314-1-unknown	MTRHGK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y314-133-	ALSGTS...	133		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9Y314-133-	ALSGTS...	133		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9Y314-133-	ALSGTS...	133		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y314-133-	ALSGTS...	133		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y314-133-	ALSGTS...	133		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y314-267-unknown	KLTDRD...	267	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13616

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RGTRRE	96	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468974
...TRDSLS	230	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471929
...AVLRPS	241	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000473109
...PVTGDK	266	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13616
...PVMQA	301	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	266	TGDK.\|.KLTD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)