Q9Y3T6: R3H and coiled-coil domain-containing protein 1 {ECO:0000312|HGNC:HGNC:27329}

General Information

Protein names	- R3H and coiled-coil domain-containing protein 1 {ECO:0000312\|HGNC:HGNC:27329}
Gene names	R3HCC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y3T6

7 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of R3H and coiled-coil domain-containing protein 1 - Isoform 2 of R3H and coiled-coil domain-containing protein 1

Sequence View

        10         20         30         40         50         60
MALLCLDGVF LSSAENDFVH RIQEELDRFL LQKQLSKVLL FPPLSSRLRY LIHRTAENFD
        70         80         90        100        110        120
LLSSFSVGEG WKRRTVICHQ DIRVPSSDGL SGPCRAPASC PSRYHGPRPI SNQGAAAVPR
       130        140        150        160        170        180
GARAGRWYRG RKPDQPLYVP RVLRRQEEWG LTSTSVLKRE APAGRDPEEP GDVGAGDPNS
       190        200        210        220        230        240
DQGLPVLMTQ GTEDLKGPGQ RCENEPLLDP VGPEPLGPES QSGKGDMVEM ATRFGSTLQL
       250        260        270        280        290        300
DLEKGKESLL EKRLVAEEEE DEEEVEEDGP SSCSEDDYSE LLQEITDNLT KKEIQIEKIH
       310        320        330        340        350        360
LDTSSFVEEL PGEKDLAHVV EIYDFEPALK TEDLLATFSE FQEKGFRIQW VDDTHALGIF
       370        380        390        400        410        420
PCLASAAEAL TREFSVLKIR PLTQGTKQSK LKALQRPKLL RLVKERPQTN ATVARRLVAR
       430        440
ALGLQHKKKE RPAVRGPLPP         10         20         30         40         50         60
MALLCLDGVF LSSAENDFVH RIQEELDRFL LQKQLSKVLL FPPLSSRLRY LIHRTAENFD
        70         80         90        100        110        120
LLSSFSVGEG WKRRTVICHQ DIRVPSSDGL SGPCRAPASC PSRYHGPRPI SNQGAAAVPR
       130        140        150        160        170        180
GARAGRWYRG RKPDQPLYVP RVLRRQEEWG LTSTSVLKRE APAGRDPEEP GDVGAGDPNS
       190        200        210        220        230        240
DQGLPVLMTQ GTEDLKGPGQ RCENEPLLDP VGPEPLGPES QSGKGDMVEM ATRFGSTLQL
       250        260        270        280        290        300
DLEKGKESLL EKRLVAEEEE DEEEVEEDGP SSCSEDDYSE LLQEITDNLT KKEIQIEKIH
       310        320        330        340        350        360
LDTSSFVEEL PGEKDLAHVV EIYDFEPALK TEDLLATFSE FQEKGFRIQW VDDTHALGIF
       370        380        390        400        410        420
PCLASAAEAL TREFSVLKIR PLTQGTKQSK LKALQRPKLL RLVKERPQTN ATVARRLVAR
       430        440
ALGLQHKKKE RPAVRGPLPP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y3T6-1-unknown	MALLCL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y3T6-41-unknown	FPPLSS...	41	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q9Y3T6-228-unknown	VEMATR...	228	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86791
Q9Y3T6-257-unknown	EEEEDE...	257	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15157
Q9Y3T6-257-unknown	EEEEDE...	257	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137520
Q9Y3T6-260-unknown	EDEEEV...	260	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13634
Q9Y3T6-260-unknown	EDEEEV...	260	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137777
Q9Y3T6-343-unknown	EKGFRI...	343	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176459
Q9Y3T6-343-	EKGFRI...	343		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KRLVAE	256	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15157
...KRLVAE	256	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120499
...VAEEEE	259	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13634
...VAEEEE	259	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120777
...	480	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...	480	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82409

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	256	LVAE.\|.EEEE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	259	EEEE.\|.EDEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)