Q9Y4W2: Ribosomal biogenesis protein LAS1L

General Information

Protein names	- Ribosomal biogenesis protein LAS1L - Protein LAS1 homolog
Gene names	LAS1L
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y4W2

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Ribosomal biogenesis protein LAS1L - Isoform 3 of Ribosomal biogenesis protein LAS1L - Isoform 4 of Ribosomal biogenesis protein LAS1L

Sequence View

        10         20         30         40         50         60
MSWESGAGPG LGSQGMDLVW SAWYGKCVKG KGSLPLSAHG IVVAWLSRAE WDQVTVYLFC
        70         80         90        100        110        120
DDHKLQRYAL NRITVWRSRS GNELPLAVAS TADLIRCKLL DVTGGLGTDE LRLLYGMALV
       130        140        150        160        170        180
RFVNLISERK TKFAKVPLKC LAQEVNIPDW IVDLRHELTH KKMPHINDCR RGCYFVLDWL
       190        200        210        220        230        240
QKTYWCRQLE NSLRETWELE EFREGIEEED QEEDKNIVVD DITEQKPEPQ DDGKSTESDV
       250        260        270        280        290        300
KADGDSKGSE EVDSHCKKAL SHKELYERAR ELLVSYEEEQ FTVLEKFRYL PKAIKAWNNP
       310        320        330        340        350        360
SPRVECVLAE LKGVTCENRE AVLDAFLDDG FLVPTFEQLA ALQIEYEDGQ TEVQRGEGTD
       370        380        390        400        410        420
PKSHKNVDLN DVLVPKPFSQ FWQPLLRGLH SQNFTQALLE RMLSELPALG ISGIRPTYIL
       430        440        450        460        470        480
RWTVELIVAN TKTGRNARRF SAGQWEARRG WRLFNCSASL DWPRMVESCL GSPCWASPQL
       490        500        510        520        530        540
LRIIFKAMGQ GLPDEEQEKL LRICSIYTQS GENSLVQEGS EASPIGKSPY TLDSLYWSVK
       550        560        570        580        590        600
PASSSFGSEA KAQQQEEQGS VNDVKEEEKE EKEVLPDQVE EEEENDDQEE EEEDEDDEDD
       610        620        630        640        650        660
EEEDRMEVGP FSTGQESPTA ENARLLAQKR GALQGSAWQV SSEDVRWDTF PLGRMPGQTE
       670        680        690        700        710        720
DPAELMLENY DTMYLLDQPV LEQRLEPSTC KTDTLGLSCG VGSGNCSNSS SSNFEGLLWS
       730
QGQLHGLKTG LQLF         10         20         30         40         50         60
MSWESGAGPG LGSQGMDLVW SAWYGKCVKG KGSLPLSAHG IVVAWLSRAE WDQVTVYLFC
        70         80         90        100        110        120
DDHKLQRYAL NRITVWRSRS GNELPLAVAS TADLIRCKLL DVTGGLGTDE LRLLYGMALV
       130        140        150        160        170        180
RFVNLISERK TKFAKVPLKC LAQEVNIPDW IVDLRHELTH KKMPHINDCR RGCYFVLDWL
       190        200        210        220        230        240
QKTYWCRQLE NSLRETWELE EFREGIEEED QEEDKNIVVD DITEQKPEPQ DDGKSTESDV
       250        260        270        280        290        300
KADGDSKGSE EVDSHCKKAL SHKELYERAR ELLVSYEEEQ FTVLEKFRYL PKAIKAWNNP
       310        320        330        340        350        360
SPRVECVLAE LKGVTCENRE AVLDAFLDDG FLVPTFEQLA ALQIEYEDGQ TEVQRGEGTD
       370        380        390        400        410        420
PKSHKNVDLN DVLVPKPFSQ FWQPLLRGLH SQNFTQALLE RMLSELPALG ISGIRPTYIL
       430        440        450        460        470        480
RWTVELIVAN TKTGRNARRF SAGQWEARRG WRLFNCSASL DWPRMVESCL GSPCWASPQL
       490        500        510        520        530        540
LRIIFKAMGQ GLPDEEQEKL LRICSIYTQS GENSLVQEGS EASPIGKSPY TLDSLYWSVK
       550        560        570        580        590        600
PASSSFGSEA KAQQQEEQGS VNDVKEEEKE EKEVLPDQVE EEEENDDQEE EEEDEDDEDD
       610        620        630        640        650        660
EEEDRMEVGP FSTGQESPTA ENARLLAQKR GALQGSAWQV SSEDVRWDTF PLGRMPGQTE
       670        680        690        700        710        720
DPAELMLENY DTMYLLDQPV LEQRLEPSTC KTDTLGLSCG VGSGNCSNSS SSNFEGLLWS
       730
QGQLHGLKTG LQLF         10         20         30         40         50         60
MSWESGAGPG LGSQGMDLVW SAWYGKCVKG KGSLPLSAHG IVVAWLSRAE WDQVTVYLFC
        70         80         90        100        110        120
DDHKLQRYAL NRITVWRSRS GNELPLAVAS TADLIRCKLL DVTGGLGTDE LRLLYGMALV
       130        140        150        160        170        180
RFVNLISERK TKFAKVPLKC LAQEVNIPDW IVDLRHELTH KKMPHINDCR RGCYFVLDWL
       190        200        210        220        230        240
QKTYWCRQLE NSLRETWELE EFREGIEEED QEEDKNIVVD DITEQKPEPQ DDGKSTESDV
       250        260        270        280        290        300
KADGDSKGSE EVDSHCKKAL SHKELYERAR ELLVSYEEEQ FTVLEKFRYL PKAIKAWNNP
       310        320        330        340        350        360
SPRVECVLAE LKGVTCENRE AVLDAFLDDG FLVPTFEQLA ALQIEYEDGQ TEVQRGEGTD
       370        380        390        400        410        420
PKSHKNVDLN DVLVPKPFSQ FWQPLLRGLH SQNFTQALLE RMLSELPALG ISGIRPTYIL
       430        440        450        460        470        480
RWTVELIVAN TKTGRNARRF SAGQWEARRG WRLFNCSASL DWPRMVESCL GSPCWASPQL
       490        500        510        520        530        540
LRIIFKAMGQ GLPDEEQEKL LRICSIYTQS GENSLVQEGS EASPIGKSPY TLDSLYWSVK
       550        560        570        580        590        600
PASSSFGSEA KAQQQEEQGS VNDVKEEEKE EKEVLPDQVE EEEENDDQEE EEEDEDDEDD
       610        620        630        640        650        660
EEEDRMEVGP FSTGQESPTA ENARLLAQKR GALQGSAWQV SSEDVRWDTF PLGRMPGQTE
       670        680        690        700        710        720
DPAELMLENY DTMYLLDQPV LEQRLEPSTC KTDTLGLSCG VGSGNCSNSS SSNFEGLLWS
       730
QGQLHGLKTG LQLF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y4W2-1-unknown	MSWESG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y4W2-1-unknown	MSWESG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79392
Q9Y4W2-1-unknown	MSWESG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79393
Q9Y4W2-1-unknown	MSWESG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79394
Q9Y4W2-538-unknown	SVKPAS...	538	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168174
Q9Y4W2-538-unknown	SVKPAS...	538	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168175
Q9Y4W2-538-	SVKPAS...	538		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9Y4W2-538-	SVKPAS...	538		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y4W2-538-	SVKPAS...	538		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y4W2-612-unknown	STGQES...	612	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13641
Q9Y4W2-612-unknown	STGQES...	612	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154014
Q9Y4W2-612-unknown	STGQES...	612	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154525

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EVGPFS	611	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13641
...EVGPFS	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137434
...EVGPFS	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137947
...GLQLF	734	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GLQLF	734	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75011
...GLQLF	734	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75010

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	611	GPFS.\|.STGQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)