Q9Y5J1: U3 small nucleolar RNA-associated protein 18 homolog

General Information

Protein names	- U3 small nucleolar RNA-associated protein 18 homolog - WD repeat-containing protein 50
Gene names	UTP18
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y5J1

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPPERRRRMK LDRRTGAKPK RKPGMRPDWK AGAGPGGPPQ KPAPSSQRKP PARPSAAAAA
        70         80         90        100        110        120
IAVAAAEEER RLRQRNRLRL EEDKPAVERC LEELVFGDVE NDEDALLRRL RGPRVQEHED
       130        140        150        160        170        180
SGDSEVENEA KGNFPPQKKP VWVDEEDEDE EMVDMMNNRF RKDMMKNASE SKLSKDNLKK
       190        200        210        220        230        240
RLKEEFQHAM GGVPAWAETT KRKTSSDDES EEDEDDLLQR TGNFISTSTS LPRGILKMKN
       250        260        270        280        290        300
CQHANAERPT VARISSVQFH PGAQIVMVAG LDNAVSLFQV DGKTNPKIQS IYLERFPIFK
       310        320        330        340        350        360
ACFSANGEEV LATSTHSKVL YVYDMLAGKL IPVHQVRGLK EKIVRSFEVS PDGSFLLING
       370        380        390        400        410        420
IAGYLHLLAM KTKELIGSMK INGRVAASTF SSDSKKVYAS SGDGEVYVWD VNSRKCLNRF
       430        440        450        460        470        480
VDEGSLYGLS IATSRNGQYV ACGSNCGVVN IYNQDSCLQE TNPKPIKAIM NLVTGVTSLT
       490        500        510        520        530        540
FNPTTEILAI ASEKMKEAVR LVHLPSCTVF SNFPVIKNKN ISHVHTMDFS PRSGYFALGN
       550
EKGKALMYRL HHYSDF

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y5J1-1-unknown	MPPERR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y5J1-95-unknown	VFGDVE...	95	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15177
Q9Y5J1-99-unknown	VENDED...	99	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13648
Q9Y5J1-192-	GVPAWA...	192		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9Y5J1-192-	GVPAWA...	192		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y5J1-291-unknown	IYLERF...	291	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000462614
Q9Y5J1-410-unknown	DVNSRK...	410	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463499

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CLEELV	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15177
...LVFGDV	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13648
...HYSDF	556	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	94	EELV.\|.VFGD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	98	FGDV.\|.VEND	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)