Q9Y6A5: Transforming acidic coiled-coil-containing protein 3

General Information

Protein names	- Transforming acidic coiled-coil-containing protein 3 - ERIC-1
Gene names	TACC3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y6A5

7 N-termini

6 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSLQVLNDKN VSNEKNTENC DFLFSPPEVT GRSSVLRVSQ KENVPPKNLA KAMKVTFQTP
        70         80         90        100        110        120
LRDPQTHRIL SPSMASKLEA PFTQDDTLGL ENSHPVWTQK ENQQLIKEVD AKTTHGILQK
       130        140        150        160        170        180
PVEADTDLLG DASPAFGSGS SSESGPGALA DLDCSSSSQS PGSSENQMVS PGKVSGSPEQ
       190        200        210        220        230        240
AVEENLSSYS LDRRVTPASE TLEDPCRTES QHKAETPHGA EEECKAETPH GAEEECRHGG
       250        260        270        280        290        300
VCAPAAVATS PPGAIPKEAC GGAPLQGLPG EALGCPAGVG TPVPADGTQT LTCAHTSAPE
       310        320        330        340        350        360
STAPTNHLVA GRAMTLSPQE EVAAGQMASS SRSGPVKLEF DVSDGATSKR APPPRRLGER
       370        380        390        400        410        420
SGLKPPLRKA AVRQQKAPQE VEEDDGRSGA GEDPPMPASR GSYHLDWDKM DDPNFIPFGG
       430        440        450        460        470        480
DTKSGCSEAQ PPESPETRLG QPAAEQLHAG PATEEPGPCL SQQLHSASAE DTPVVQLAAE
       490        500        510        520        530        540
TPTAESKERA LNSASTSLPT SCPGSEPVPT HQQGQPALEL KEESFRDPAE VLGTGAEVDY
       550        560        570        580        590        600
LEQFGTSSFK ESALRKQSLY LKFDPLLRDS PGRPVPVATE TSSMHGANET PSGRPREAKL
       610        620        630        640        650        660
VEFDFLGALD IPVPGPPPGV PAPGGPPLST GPIVDLLQYS QKDLDAVVKA TQEENRELRS
       670        680        690        700        710        720
RCEELHGKNL ELGKIMDRFE EVVYQAMEEV QKQKELSKAE IQKVLKEKDQ LTTDLNSMEK
       730        740        750        760        770        780
SFSDLFKRFE KQKEVIEGYR KNEESLKKCV EDYLARITQE GQRYQALKAH AEEKLQLANE
       790        800        810        820        830
EIAQVRSKAQ AEALALQASL RKEQMRIQSL EKTVEQKTKE NEELTRICDD LISKMEKI

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y6A5-2-unknown	MSLQVL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y6A5-2-Acetylation	SLQVLN...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y6A5-2-Acetylation	SLQVLN...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9Y6A5-22-	FLFSPP...	22			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9Y6A5-389-	GAGEDP...	389			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y6A5-415-	FIPFGG...	415			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y6A5-478-	AAETPT...	478			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y6A5-605-unknown	FLGALD...	605		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13659

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...PHGAEE	221	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000415914
...AETPHG	230	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000418095
...FKESAL	553	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000419210
...PVATET	580	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000420838
...LVEFDF	604	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13659
...KMEKI	838	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KMEKI	838		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	604	EFDF.\|.FLGA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)