Q9Y6E0: Serine/threonine-protein kinase 24

General Information

Protein names	- Serine/threonine-protein kinase 24 - 2.7.11.1 - Mammalian STE20-like protein kinase 3 - MST-3 - STE20-like kinase MST3 - Serine/threonine-protein kinase 24 36 kDa subunit - Mammalian STE20-like protein kinase 3 N-terminal - MST3/N - Serine/threonine-protein kinase 24 12 kDa subunit - Mammalian STE20-like protein kinase 3 C-terminal - MST3/C
Gene names	STK24
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y6E0

4 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDSRAQLWGL ALNKRRATLP HPGGSTNLKA DPEELFTKLE KIGKGSFGEV FKGIDNRTQK
        70         80         90        100        110        120
VVAIKIIDLE EAEDEIEDIQ QEITVLSQCD SPYVTKYYGS YLKDTKLWII MEYLGGGSAL
       130        140        150        160        170        180
DLLEPGPLDE TQIATILREI LKGLDYLHSE KKIHRDIKAA NVLLSEHGEV KLADFGVAGQ
       190        200        210        220        230        240
LTDTQIKRNT FVGTPFWMAP EVIKQSAYDS KADIWSLGIT AIELARGEPP HSELHPMKVL
       250        260        270        280        290        300
FLIPKNNPPT LEGNYSKPLK EFVEACLNKE PSFRPTAKEL LKHKFILRNA KKTSYLTELI
       310        320        330        340        350        360
DRYKRWKAEQ SHDDSSSEDS DAETDGQASG GSDSGDWIFT IREKDPKNLE NGALQPSDLD
       370        380        390        400        410        420
RNKMKDIPKR PFSQCLSTII SPLFAELKEK SQACGGNLGS IEELRGAIYL AEEACPGISD
       430        440
TMVAQLVQRL QRYSLSGGGT SSH

Isoforms

- Isoform A of Serine/threonine-protein kinase 24

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y6E0-1-unknown	MDSRAQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y6E0-253-unknown	GNYSKP...	253	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8166
Q9Y6E0-253-unknown	GNYSKP...	253	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148160
Q9Y6E0-326-	GQASGG...	326		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9Y6E0-326-	GQASGG...	326		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y6E0-326-	GQASGG...	326		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y6E0-326-unknown	GQASGG...	326	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y6E0-326-unknown	GQASGG...	326	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2367
Q9Y6E0-326-unknown	GQASGG...	326	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3174
Q9Y6E0-326-unknown	GQASGG...	326	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2982
Q9Y6E0-326-unknown	GQASGG...	326	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116156

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PPTLEG	252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8166
...PPTLEG	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131527
...DAETDG	325	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DAETDG	325	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2367
...DAETDG	325	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3174
...DAETDG	325	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2982
...DAETDG	325	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92395
...GTSSH	443	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GTSSH	443	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86537

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	252	TLEG.\|.GNYS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP3_HUMAN	325	ETDG.\|.GQAS	inferred from experiment	unknown	MEROPS	DeAizpurua HJ	Johnston AM et al.:SPAK, a STE20/SPS1-related kina... (C14.003)	10980603,
CASP8_HUMAN	325	ETDG.\|.GQAS	inferred from experiment	unknown	MEROPS	DeAizpurua HJ	Johnston AM et al.:SPAK, a STE20/SPS1-related kina... (C14.003)	10980603,
CASP7_HUMAN	325	ETDG.\|.GQAS	inferred from experiment	unknown	MEROPS	DeAizpurua HJ	Johnston AM et al.:SPAK, a STE20/SPS1-related kina... (C14.003)	10980603,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)