O00505: Importin subunit alpha-4

General Information

Protein names	- Importin subunit alpha-4 - Importin alpha Q2 - Qip2 - Karyopherin subunit alpha-3 - SRP1-gamma
Gene names	KPNA3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00505

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAENPSLENH RIKSFKNKGR DVETMRRHRN EVTVELRKNK RDEHLLKKRN VPQEESLEDS
        70         80         90        100        110        120
DVDADFKAQN VTLEAILQNA TSDNPVVQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV
       130        140        150        160        170        180
KCLERDDNPS LQFEAAWALT NIASGTSAQT QAVVQSNAVP LFLRLLRSPH QNVCEQAVWA
       190        200        210        220        230        240
LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVIVNLCRN KDPPPPMETV
       250        260        270        280        290        300
QEILPALCVL IYHTDINILV DTVWALSYLT DGGNEQIQMV IDSGVVPFLV PLLSHQEVKV
       310        320        330        340        350        360
QTAALRAVGN IVTGTDEQTQ VVLNCDVLSH FPNLLSHPKE KINKEAVWFL SNITAGNQQQ
       370        380        390        400        410        420
VQAVIDAGLI PMIIHQLAKG DFGTQKEAAW AISNLTISGR KDQVEYLVQQ NVIPPFCNLL
       430        440        450        460        470        480
SVKDSQVVQV VLDGLKNILI MAGDEASTIA EIIEECGGLE KIEVLQQHEN EDIYKLAFEI
       490        500        510        520
IDQYFSGDDI DEDPCLIPEA TQGGTYNFDP TANLQTKEFN F

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00505-2-unknown	MAENPS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00505-2-Acetylation	AENPSL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00505-2-Acetylation	AENPSL...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O00505-50-	NVPQEE...	50			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O00505-60-unknown	SDVDAD...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10651

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ESLEDS	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10651
...ATQGGT	504	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393869
...KEFNF	521	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	59	LEDS.\|.SDVD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)