O00571: ATP-dependent RNA helicase DDX3X

General Information

Protein names	- ATP-dependent RNA helicase DDX3X - 3.6.4.13 - DEAD box protein 3, X-chromosomal - DEAD box, X isoform - Helicase-like protein 2 - HLP2
Gene names	DDX3X
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00571

9 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSHVAVENAL GLDQQFAGLD LNSSDNQSGG STASKGRYIP PHLRNREATK GFYDKDSSGW
        70         80         90        100        110        120
SSSKDKDAYS SFGSRSDSRG KSSFFSDRGS GSRGRFDDRG RSDYDGIGSR GDRSGFGKFE
       130        140        150        160        170        180
RGGNSRWCDK SDEDDWSKPL PPSERLEQEL FSGGNTGINF EKYDDIPVEA TGNNCPPHIE
       190        200        210        220        230        240
SFSDVEMGEI IMGNIELTRY TRPTPVQKHA IPIIKEKRDL MACAQTGSGK TAAFLLPILS
       250        260        270        280        290        300
QIYSDGPGEA LRAMKENGRY GRRKQYPISL VLAPTRELAV QIYEEARKFS YRSRVRPCVV
       310        320        330        340        350        360
YGGADIGQQI RDLERGCHLL VATPGRLVDM MERGKIGLDF CKYLVLDEAD RMLDMGFEPQ
       370        380        390        400        410        420
IRRIVEQDTM PPKGVRHTMM FSATFPKEIQ MLARDFLDEY IFLAVGRVGS TSENITQKVV
       430        440        450        460        470        480
WVEESDKRSF LLDLLNATGK DSLTLVFVET KKGADSLEDF LYHEGYACTS IHGDRSQRDR
       490        500        510        520        530        540
EEALHQFRSG KSPILVATAV AARGLDISNV KHVINFDLPS DIEEYVHRIG RTGRVGNLGL
       550        560        570        580        590        600
ATSFFNERNI NITKDLLDLL VEAKQEVPSW LENMAYEHHY KGSSRGRSKS SRFSGGFGAR
       610        620        630        640        650        660
DYRQSSGASS SSFSSSRASS SRSGGGGHGS SRGFGGGGYG GFYNSDGYGG NYNSQGVDWW

GN

Isoforms

- Isoform 2 of ATP-dependent RNA helicase DDX3X

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00571-2-unknown	MSHVAV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00571-1-unknown	MSHVAV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72544
O00571-2-Acetylation	SHVAVE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00571-2-Acetylation	SHVAVE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O00571-2-Acetylation	SHVAVE...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O00571-2-Acetylation	SHVAVE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110976
O00571-9-unknown	ALGLDQ...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13703
O00571-9-unknown	ALGLDQ...	9		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194828
O00571-11-unknown	GLDQQF...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13704
O00571-11-unknown	GLDQQF...	11		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194908
O00571-14-unknown	QQFAGL...	14		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10664
O00571-14-unknown	QQFAGL...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136510
O00571-20-unknown	DLNSSD...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13705
O00571-47-	EATKGF...	47			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O00571-114-unknown	SGFGKF...	114		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9876
O00571-114-unknown	SGFGKF...	114		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142292

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VAVENA	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13703
...VENALG	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13704
...ALGLDQ	13	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10664
...QFAGLD	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13705
...SRGDRS	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9876
...SRGDRS	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125482
...DWWGN	662	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DWWGN	662	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68162

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	8	VENA.\|.ALGL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	10	NALG.\|.GLDQ	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	13	GLDQ.\|.QQFA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	19	AGLD.\|.DLNS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	113	GDRS.\|.SGFG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)