O14744: Protein arginine N-methyltransferase 5

General Information

Protein names	- Protein arginine N-methyltransferase 5 - 2.1.1.320 {ECO:0000269\|PubMed:19011621, ECO:0000269\|PubMed:21081503, ECO:0000269\|PubMed:23071334} - 72 kDa ICln-binding protein - Histone-arginine N-methyltransferase PRMT5 - Jak-binding protein 1 - Shk1 kinase-binding protein 1 homolog - SKB1 homolog - SKB1Hs - Protein arginine N-methyltransferase 5, N-terminally processed
Gene names	PRMT5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14744

11 N-termini

10 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein arginine N-methyltransferase 5 - Isoform 4 of Protein arginine N-methyltransferase 5 - Isoform 5 of Protein arginine N-methyltransferase 5 - Isoform 3 of Protein arginine N-methyltransferase 5

Sequence View

        10         20         30         40         50         60
MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK
        70         80         90        100        110        120
NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR RNSEAAMLQE LNFGAYLGLP
       130        140        150        160        170        180
AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDIIEN APTTHTEEYS
       190        200        210        220        230        240
GEEKTWMWWH NFRTLCDYSK RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK
       250        260        270        280        290        300
KGFPVLSKMH QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF
       310        320        330        340        350        360
AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKDTNVQV
       370        380        390        400        410        420
LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT LENWQFEEWG SQVTVVSSDM
       430        440        450        460        470        480
REWVAPEKAD IIVSELLGSF ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL
       490        500        510        520        530        540
YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF
       550        560        570        580        590        600
PVEVNTVLHG FAGYFETVLY QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV
       610        620        630
RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL         10         20         30         40         50         60
MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK
        70         80         90        100        110        120
NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR RNSEAAMLQE LNFGAYLGLP
       130        140        150        160        170        180
AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDIIEN APTTHTEEYS
       190        200        210        220        230        240
GEEKTWMWWH NFRTLCDYSK RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK
       250        260        270        280        290        300
KGFPVLSKMH QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF
       310        320        330        340        350        360
AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKDTNVQV
       370        380        390        400        410        420
LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT LENWQFEEWG SQVTVVSSDM
       430        440        450        460        470        480
REWVAPEKAD IIVSELLGSF ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL
       490        500        510        520        530        540
YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF
       550        560        570        580        590        600
PVEVNTVLHG FAGYFETVLY QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV
       610        620        630
RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL         10         20         30         40         50         60
MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK
        70         80         90        100        110        120
NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR RNSEAAMLQE LNFGAYLGLP
       130        140        150        160        170        180
AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDIIEN APTTHTEEYS
       190        200        210        220        230        240
GEEKTWMWWH NFRTLCDYSK RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK
       250        260        270        280        290        300
KGFPVLSKMH QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF
       310        320        330        340        350        360
AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKDTNVQV
       370        380        390        400        410        420
LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT LENWQFEEWG SQVTVVSSDM
       430        440        450        460        470        480
REWVAPEKAD IIVSELLGSF ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL
       490        500        510        520        530        540
YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF
       550        560        570        580        590        600
PVEVNTVLHG FAGYFETVLY QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV
       610        620        630
RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL         10         20         30         40         50         60
MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK
        70         80         90        100        110        120
NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR RNSEAAMLQE LNFGAYLGLP
       130        140        150        160        170        180
AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDIIEN APTTHTEEYS
       190        200        210        220        230        240
GEEKTWMWWH NFRTLCDYSK RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK
       250        260        270        280        290        300
KGFPVLSKMH QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF
       310        320        330        340        350        360
AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKDTNVQV
       370        380        390        400        410        420
LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT LENWQFEEWG SQVTVVSSDM
       430        440        450        460        470        480
REWVAPEKAD IIVSELLGSF ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL
       490        500        510        520        530        540
YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF
       550        560        570        580        590        600
PVEVNTVLHG FAGYFETVLY QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV
       610        620        630
RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 10 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14744-1-unknown	MAAMAV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14744-1-unknown	MAAMAV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66988
O14744-2-unknown	MAAMAV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14744-2-Acetylation	AAMAVG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14744-2-Acetylation	AAMAVG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O14744-2-Acetylation	AAMAVG...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O14744-2-Acetylation	AAMAVG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O14744-2-Acetylation	AAMAVG...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O14744-2-Acetylation	AAMAVG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110975
O14744-3-acetylation	AMAVGG...	3	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O14744-3-acetylation	AMAVGG...	3	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181075
O14744-43-unknown	MPVFHP...	43		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452411
O14744-43-unknown	MPVFHP...	43		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131852
O14744-43-unknown	MPVFHP...	43		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131853
O14744-43-unknown	MPVFHP...	43		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131855
O14744-43-unknown	MPVFHP...	43		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131854
O14744-69-unknown	SDLLLS...	69		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10683
O14744-69-unknown	SDLLLS...	69		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139353
O14744-69-unknown	SDLLLS...	69		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139354
O14744-100-unknown	RRNSEA...	100		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452409
O14744-100-unknown	RRNSEA...	100		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131846
O14744-107-unknown	MLQELN...	107		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444915
O14744-107-unknown	MLQELN...	107		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131857
O14744-249-unknown	MHQRLI...	249		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452509
O14744-249-unknown	MHQRLI...	249		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131850
O14744-249-unknown	MHQRLI...	249		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131849
O14744-249-unknown	MHQRLI...	249		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131848
O14744-402-unknown	ENWQFE...	402		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451245
O14744-402-unknown	ENWQFE...	402		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131842
O14744-402-unknown	ENWQFE...	402		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131844
O14744-402-unknown	ENWQFE...	402		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131843
O14744-402-unknown	ENWQFE...	402		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131841
O14744-451-unknown	DGAQHF...	451		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6994
O14744-451-unknown	DGAQHF...	451		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149346
O14744-451-unknown	DGAQHF...	451		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151838
O14744-451-unknown	DGAQHF...	451		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152104
O14744-451-unknown	DGAQHF...	451		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152541

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GPQTRS	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10683
...GPQTRS	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122430
...GPQTRS	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122431
...GPQTRS	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153902
...GPQTRS	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153903
...PTTHTE	176	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409482
...PTTHTE	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112627
...PTTHTE	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112626
...PTTHTE	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112625
...EIGADL	211	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452411
...EIGADL	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112623
...EIGADL	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112622
...EIGADL	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112621
...DRWLGE	223	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450919
...DRWLGE	223	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112619
...DRWLGE	223	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112618
...DRWLGE	223	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112617
...WLGEPI	225	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452218
...WLGEPI	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112615
...WLGEPI	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112614
...WLGEPI	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112613
...KYSQYQ	337	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450737
...KYSQYQ	337	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112609
...KYSQYQ	337	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112611
...KYSQYQ	337	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112610
...KYSQYQ	337	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112608
...RVPEEE	352	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452509
...RVPEEE	352	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112604
...RVPEEE	352	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112606
...RVPEEE	352	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112605
...RVPEEE	352	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112603
...KQADRR	384	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452409
...KQADRR	384	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112599
...KQADRR	384	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112601
...KQADRR	384	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112600
...KQADRR	384	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112598
...SPECLD	450	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6994
...SPECLD	450	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132731
...SPECLD	450	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135244
...SPECLD	450	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135513
...SPECLD	450	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135953
...YTIGL	637	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YTIGL	637	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62605
...YTIGL	637	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62607
...YTIGL	637	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62606
...YTIGL	637	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62604

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	68	QTRS.\|.SDLL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	450	ECLD.\|.DGAQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)