O14818: Proteasome subunit alpha type-7

General Information

Protein names	- Proteasome subunit alpha type-7 - 3.4.25.1 {ECO:0000269\|PubMed:27176742} - Proteasome subunit RC6-1 - Proteasome subunit XAPC7
Gene names	PSMA7
Organism	Homo sapiens
Protease Family
Protease ID	T01.979
Chromosome location
UniProt ID	O14818

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Proteasome subunit alpha type-7 - Isoform 3 of Proteasome subunit alpha type-7

Sequence View

        10         20         30         40         50         60
MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDI VVLGVEKKSV AKLQDERTVR
        70         80         90        100        110        120
KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ
       130        140        150        160        170        180
SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKNYTDEA
       190        200        210        220        230        240
IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVA EIEKEKEENE

KKKQKKAS         10         20         30         40         50         60
MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDI VVLGVEKKSV AKLQDERTVR
        70         80         90        100        110        120
KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ
       130        140        150        160        170        180
SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKNYTDEA
       190        200        210        220        230        240
IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVA EIEKEKEENE

KKKQKKAS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14818-1-unknown	MSYDRA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14818-1-unknown	MSYDRA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86351
O14818-2-acetylation	SYDRAI...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O14818-2-acetylation	SYDRAI...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181077
O14818-14-	GHLFQV...	14			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O14818-14-unknown	GHLFQV...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165727
O14818-21-unknown	YAQEAV...	21		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6999
O14818-21-unknown	YAQEAV...	21		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136917
O14818-71-unknown	MAFAGL...	71		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86350
O14818-71-unknown	MAFAGL...	71		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100322
O14818-74-unknown	AGLTAD...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10687
O14818-74-unknown	AGLTAD...	74		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140910
O14818-74-unknown	AGLTAD...	74		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196553
O14818-97-	TVEDPV...	97			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O14818-97-unknown	TVEDPV...	97		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181079

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LFQVEY	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6999
...VCMAFA	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10687
...VCMAFA	73	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124053
...QKKAS	248	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QKKAS	248	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81968

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	20	QVEY.\|.YAQE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	73	MAFA.\|.AGLT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)