O15160: DNA-directed RNA polymerases I and III subunit RPAC1

General Information

Protein names	- DNA-directed RNA polymerases I and III subunit RPAC1 - DNA-directed RNA polymerase I subunit C - RNA polymerases I and III subunit AC1 - AC40 - DNA-directed RNA polymerases I and III 40 kDa polypeptide - RPA40 - RPA39 - RPC40
Gene names	POLR1C
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15160

6 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAASQAVEEM RSRVVLGEFG VRNVHTTDFP GNYSGYDDAW DQDRFEKNFR VDVVHMDENS
        70         80         90        100        110        120
LEFDMVGIDA AIANAFRRIL LAEVPTMAVE KVLVYNNTSI VQDEILAHRL GLIPIHADPR
       130        140        150        160        170        180
LFEYRNQGDE EGTEIDTLQF RLQVRCTRNP HAAKDSSDPN ELYVNHKVYT RHMTWIPLGN
       190        200        210        220        230        240
QADLFPEGTI RPVHDDILIA QLRPGQEIDL LMHCVKGIGK DHAKFSPVAT ASYRLLPDIT
       250        260        270        280        290        300
LLEPVEGEAA EELSRCFSPG VIEVQEVQGK KVARVANPRL DTFSREIFRN EKLKKVVRLA
       310        320        330        340
RVRDHYIFSV ESTGVLPPDV LVSEAIKVLM GKCRRFLDEL DAVQMD

Isoforms

- Isoform 2 of DNA-directed RNA polymerases I and III subunit RPAC1

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15160-1-unknown	MAASQA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88106
O15160-2-unknown	MAASQA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15160-2-Acetylation	AASQAV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15160-2-Acetylation	AASQAV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O15160-2-Acetylation	AASQAV...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O15160-2-Acetylation	AASQAV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O15160-2-Acetylation	AASQAV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111506
O15160-31-unknown	GNYSGY...	31		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171452
O15160-31-	GNYSGY...	31			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15160-31-	GNYSGY...	31			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O15160-31-	GNYSGY...	31			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O15160-249-unknown	AAEELS...	249		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10703
O15160-249-unknown	AAEELS...	249		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148389

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...PVEGEA	248	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10703
...PVEGEA	248	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt131761
...AVQMD	346	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...AVQMD	346		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AVQMD	346		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...AVQMD	346		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AVQMD	346		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	248	EGEA.\|.AAEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)