O15541: E3 ubiquitin-protein ligase RNF113A

General Information

Protein names	- E3 ubiquitin-protein ligase RNF113A - 2.3.2.27 {ECO:0000269\|PubMed:28978524, ECO:0000269\|PubMed:29144457} - Cwc24 homolog {ECO:0000305} - RING finger protein 113A - Zinc finger protein 183 {ECO:0000303\|PubMed:9224902}
Gene names	RNF113A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15541

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEQLSPGKA VDQVCTFLFK KPGRKGAAGR RKRPACDPEP GESGSSSDEG CTVVRPEKKR
        70         80         90        100        110        120
VTHNPMIQKT RDSGKQKAAY GDLSSEEEEE NEPESLGVVY KSTRSAKPVG PEDMGATAVY
       130        140        150        160        170        180
ELDTEKERDA QAIFERSQKI QEELRGKEDD KIYRGINNYQ KYMKPKDTSM GNASSGMVRK
       190        200        210        220        230        240
GPIRAPEHLR ATVRWDYQPD ICKDYKETGF CGFGDSCKFL HDRSDYKHGW QIERELDEGR
       250        260        270        280        290        300
YGVYEDENYE VGSDDEEIPF KCFICRQSFQ NPVVTKCRHY FCESCALQHF RTTPRCYVCD
       310        320        330        340
QQTNGVFNPA KELIAKLEKH RATGEGGASD LPEDPDEDAI PIT

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15541-2-unknown	MAEQLS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15541-2-Acetylation	AEQLSP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15541-2-Acetylation	AEQLSP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O15541-2-Acetylation	AEQLSP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O15541-105-	SAKPVG...	105			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O15541-105-	SAKPVG...	105			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15541-105-	SAKPVG...	105			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O15541-105-	SAKPVG...	105			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O15541-105-	SAKPVG...	105			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O15541-105-	SAKPVG...	105			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O15541-255-unknown	DEEIPF...	255		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10719

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...EVGSDD	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10719
	...AIPIT	343	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	254	GSDD.\|.DEEI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)