O43182: Rho GTPase-activating protein 6

General Information

Protein names	- Rho GTPase-activating protein 6 - Rho-type GTPase-activating protein 6 - Rho-type GTPase-activating protein RhoGAPX-1
Gene names	ARHGAP6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43182

8 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of Rho GTPase-activating protein 6 - Isoform 2 of Rho GTPase-activating protein 6 - Isoform 4 of Rho GTPase-activating protein 6 - Isoform 5 of Rho GTPase-activating protein 6

Sequence View

        10         20         30         40         50         60
MSAQSLLHSV FSCSSPASSS AASAKGFSKR KLRQTRSLDP ALIGGCGSDE AGAEGSARGA
        70         80         90        100        110        120
TAGRLYSPSL PAESLGPRLA SSSRGPPPRA TRLPPPGPLC SSFSTPSTPQ EKSPSGSFHF
       130        140        150        160        170        180
DYEVPLGRGG LKKSMAWDLP SVLAGPASSR SASSILCSSG GGPNGIFASP RRWLQQRKFQ
       190        200        210        220        230        240
SPPDSRGHPY VVWKSEGDFT WNSMSGRSVR LRSVPIQSLS ELERARLQEV AFYQLQQDCD
       250        260        270        280        290        300
LSCQITIPKD GQKRKKSLRK KLDSLGKEKN KDKEFIPQAF GMPLSQVIAN DRAYKLKQDL
       310        320        330        340        350        360
QRDEQKDASD FVASLLPFGN KRQNKELSSS NSSLSSTSET PNESTSPNTP EPAPRARRRG
       370        380        390        400        410        420
AMSVDSITDL DDNQSRLLEA LQLSLPAEAQ SKKEKARDKK LSLNPIYRQV PRLVDSCCQH
       430        440        450        460        470        480
LEKHGLQTVG IFRVGSSKKR VRQLREEFDR GIDVSLEEEH SVHDVAALLK EFLRDMPDPL
       490        500        510        520        530        540
LTRELYTAFI NTLLLEPEEQ LGTLQLLIYL LPPCNCDTLH RLLQFLSIVA RHADDNISKD
       550        560        570        580        590        600
GQEVTGNKMT SLNLATIFGP NLLHKQKSSD KEFSVQSSAR AEESTAIIAV VQKMIENYEA
       610        620        630        640        650        660
LFMVPPDLQN EVLISLLETD PDVVDYLLRR KASQSSSPDM LQSEVSFSVG GRHSSTDSNK
       670        680        690        700        710        720
ASSGDISPYD NNSPVLSERS LLAMQEDAAP GGSEKLYRVP GQFMLVGHLS SSKSRESSPG
       730        740        750        760        770        780
PRLGKDLSEE PFDIWGTWHS TLKSGSKDPG MTGSSGDIFE SSSLRAGPCS LSQGNLSPNW
       790        800        810        820        830        840
PRWQGSPAEL DSDTQGARRT QAAAPATEGR AHPAVSRACS TPHVQVAGKA ERPTARSEQY
       850        860        870        880        890        900
LTLSGAHDLS ESELDVAGLQ SRATPQCQRP HGSGRDDKRP PPPYPGPGKP AAAAAWIQGP
       910        920        930        940        950        960
PEGVETPTDQ GGQAAEREQQ VTQKKLSSAN SLPAGEQDSP RLGDAGWLDW QRERWQIWEL
       970
LSTDNPDALP ETLV         10         20         30         40         50         60
MSAQSLLHSV FSCSSPASSS AASAKGFSKR KLRQTRSLDP ALIGGCGSDE AGAEGSARGA
        70         80         90        100        110        120
TAGRLYSPSL PAESLGPRLA SSSRGPPPRA TRLPPPGPLC SSFSTPSTPQ EKSPSGSFHF
       130        140        150        160        170        180
DYEVPLGRGG LKKSMAWDLP SVLAGPASSR SASSILCSSG GGPNGIFASP RRWLQQRKFQ
       190        200        210        220        230        240
SPPDSRGHPY VVWKSEGDFT WNSMSGRSVR LRSVPIQSLS ELERARLQEV AFYQLQQDCD
       250        260        270        280        290        300
LSCQITIPKD GQKRKKSLRK KLDSLGKEKN KDKEFIPQAF GMPLSQVIAN DRAYKLKQDL
       310        320        330        340        350        360
QRDEQKDASD FVASLLPFGN KRQNKELSSS NSSLSSTSET PNESTSPNTP EPAPRARRRG
       370        380        390        400        410        420
AMSVDSITDL DDNQSRLLEA LQLSLPAEAQ SKKEKARDKK LSLNPIYRQV PRLVDSCCQH
       430        440        450        460        470        480
LEKHGLQTVG IFRVGSSKKR VRQLREEFDR GIDVSLEEEH SVHDVAALLK EFLRDMPDPL
       490        500        510        520        530        540
LTRELYTAFI NTLLLEPEEQ LGTLQLLIYL LPPCNCDTLH RLLQFLSIVA RHADDNISKD
       550        560        570        580        590        600
GQEVTGNKMT SLNLATIFGP NLLHKQKSSD KEFSVQSSAR AEESTAIIAV VQKMIENYEA
       610        620        630        640        650        660
LFMVPPDLQN EVLISLLETD PDVVDYLLRR KASQSSSPDM LQSEVSFSVG GRHSSTDSNK
       670        680        690        700        710        720
ASSGDISPYD NNSPVLSERS LLAMQEDAAP GGSEKLYRVP GQFMLVGHLS SSKSRESSPG
       730        740        750        760        770        780
PRLGKDLSEE PFDIWGTWHS TLKSGSKDPG MTGSSGDIFE SSSLRAGPCS LSQGNLSPNW
       790        800        810        820        830        840
PRWQGSPAEL DSDTQGARRT QAAAPATEGR AHPAVSRACS TPHVQVAGKA ERPTARSEQY
       850        860        870        880        890        900
LTLSGAHDLS ESELDVAGLQ SRATPQCQRP HGSGRDDKRP PPPYPGPGKP AAAAAWIQGP
       910        920        930        940        950        960
PEGVETPTDQ GGQAAEREQQ VTQKKLSSAN SLPAGEQDSP RLGDAGWLDW QRERWQIWEL
       970
LSTDNPDALP ETLV         10         20         30         40         50         60
MSAQSLLHSV FSCSSPASSS AASAKGFSKR KLRQTRSLDP ALIGGCGSDE AGAEGSARGA
        70         80         90        100        110        120
TAGRLYSPSL PAESLGPRLA SSSRGPPPRA TRLPPPGPLC SSFSTPSTPQ EKSPSGSFHF
       130        140        150        160        170        180
DYEVPLGRGG LKKSMAWDLP SVLAGPASSR SASSILCSSG GGPNGIFASP RRWLQQRKFQ
       190        200        210        220        230        240
SPPDSRGHPY VVWKSEGDFT WNSMSGRSVR LRSVPIQSLS ELERARLQEV AFYQLQQDCD
       250        260        270        280        290        300
LSCQITIPKD GQKRKKSLRK KLDSLGKEKN KDKEFIPQAF GMPLSQVIAN DRAYKLKQDL
       310        320        330        340        350        360
QRDEQKDASD FVASLLPFGN KRQNKELSSS NSSLSSTSET PNESTSPNTP EPAPRARRRG
       370        380        390        400        410        420
AMSVDSITDL DDNQSRLLEA LQLSLPAEAQ SKKEKARDKK LSLNPIYRQV PRLVDSCCQH
       430        440        450        460        470        480
LEKHGLQTVG IFRVGSSKKR VRQLREEFDR GIDVSLEEEH SVHDVAALLK EFLRDMPDPL
       490        500        510        520        530        540
LTRELYTAFI NTLLLEPEEQ LGTLQLLIYL LPPCNCDTLH RLLQFLSIVA RHADDNISKD
       550        560        570        580        590        600
GQEVTGNKMT SLNLATIFGP NLLHKQKSSD KEFSVQSSAR AEESTAIIAV VQKMIENYEA
       610        620        630        640        650        660
LFMVPPDLQN EVLISLLETD PDVVDYLLRR KASQSSSPDM LQSEVSFSVG GRHSSTDSNK
       670        680        690        700        710        720
ASSGDISPYD NNSPVLSERS LLAMQEDAAP GGSEKLYRVP GQFMLVGHLS SSKSRESSPG
       730        740        750        760        770        780
PRLGKDLSEE PFDIWGTWHS TLKSGSKDPG MTGSSGDIFE SSSLRAGPCS LSQGNLSPNW
       790        800        810        820        830        840
PRWQGSPAEL DSDTQGARRT QAAAPATEGR AHPAVSRACS TPHVQVAGKA ERPTARSEQY
       850        860        870        880        890        900
LTLSGAHDLS ESELDVAGLQ SRATPQCQRP HGSGRDDKRP PPPYPGPGKP AAAAAWIQGP
       910        920        930        940        950        960
PEGVETPTDQ GGQAAEREQQ VTQKKLSSAN SLPAGEQDSP RLGDAGWLDW QRERWQIWEL
       970
LSTDNPDALP ETLV         10         20         30         40         50         60
MSAQSLLHSV FSCSSPASSS AASAKGFSKR KLRQTRSLDP ALIGGCGSDE AGAEGSARGA
        70         80         90        100        110        120
TAGRLYSPSL PAESLGPRLA SSSRGPPPRA TRLPPPGPLC SSFSTPSTPQ EKSPSGSFHF
       130        140        150        160        170        180
DYEVPLGRGG LKKSMAWDLP SVLAGPASSR SASSILCSSG GGPNGIFASP RRWLQQRKFQ
       190        200        210        220        230        240
SPPDSRGHPY VVWKSEGDFT WNSMSGRSVR LRSVPIQSLS ELERARLQEV AFYQLQQDCD
       250        260        270        280        290        300
LSCQITIPKD GQKRKKSLRK KLDSLGKEKN KDKEFIPQAF GMPLSQVIAN DRAYKLKQDL
       310        320        330        340        350        360
QRDEQKDASD FVASLLPFGN KRQNKELSSS NSSLSSTSET PNESTSPNTP EPAPRARRRG
       370        380        390        400        410        420
AMSVDSITDL DDNQSRLLEA LQLSLPAEAQ SKKEKARDKK LSLNPIYRQV PRLVDSCCQH
       430        440        450        460        470        480
LEKHGLQTVG IFRVGSSKKR VRQLREEFDR GIDVSLEEEH SVHDVAALLK EFLRDMPDPL
       490        500        510        520        530        540
LTRELYTAFI NTLLLEPEEQ LGTLQLLIYL LPPCNCDTLH RLLQFLSIVA RHADDNISKD
       550        560        570        580        590        600
GQEVTGNKMT SLNLATIFGP NLLHKQKSSD KEFSVQSSAR AEESTAIIAV VQKMIENYEA
       610        620        630        640        650        660
LFMVPPDLQN EVLISLLETD PDVVDYLLRR KASQSSSPDM LQSEVSFSVG GRHSSTDSNK
       670        680        690        700        710        720
ASSGDISPYD NNSPVLSERS LLAMQEDAAP GGSEKLYRVP GQFMLVGHLS SSKSRESSPG
       730        740        750        760        770        780
PRLGKDLSEE PFDIWGTWHS TLKSGSKDPG MTGSSGDIFE SSSLRAGPCS LSQGNLSPNW
       790        800        810        820        830        840
PRWQGSPAEL DSDTQGARRT QAAAPATEGR AHPAVSRACS TPHVQVAGKA ERPTARSEQY
       850        860        870        880        890        900
LTLSGAHDLS ESELDVAGLQ SRATPQCQRP HGSGRDDKRP PPPYPGPGKP AAAAAWIQGP
       910        920        930        940        950        960
PEGVETPTDQ GGQAAEREQQ VTQKKLSSAN SLPAGEQDSP RLGDAGWLDW QRERWQIWEL
       970
LSTDNPDALP ETLV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43182-1-unknown	MSAQSL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43182-1-unknown	MSAQSL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87586
O43182-1-unknown	MSAQSL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87587
O43182-204-unknown	MSGRSV...	204	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87588
O43182-204-unknown	MSGRSV...	204	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87589
O43182-204-unknown	MSGRSV...	204	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt97925
O43182-204-unknown	MSGRSV...	204	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt97924
O43182-366-	SITDLD...	366		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43182-366-	SITDLD...	366		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O43182-366-	SITDLD...	366		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O43182-366-unknown	SITDLD...	366	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10729
O43182-366-unknown	SITDLD...	366	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145286
O43182-366-unknown	SITDLD...	366	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145287
O43182-366-unknown	SITDLD...	366	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151339
O43182-366-unknown	SITDLD...	366	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151978
O43182-392-unknown	KKEKAR...	392	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13738
O43182-392-unknown	KKEKAR...	392	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146220
O43182-392-unknown	KKEKAR...	392	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146221
O43182-392-unknown	KKEKAR...	392	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151882
O43182-392-unknown	KKEKAR...	392	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152402
O43182-683-unknown	AMQEDA...	683	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13743
O43182-683-unknown	AMQEDA...	683	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153187
O43182-683-unknown	AMQEDA...	683	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153188
O43182-683-unknown	AMQEDA...	683	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155692
O43182-931-	SLPAGE...	931		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O43182-931-unknown	SLPAGE...	931	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178187

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AMSVDS	365	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10729
...AMSVDS	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128577
...AMSVDS	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128578
...AMSVDS	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134741
...AMSVDS	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135386
...AEAQSK	391	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13738
...AEAQSK	391	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129524
...AEAQSK	391	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129525
...AEAQSK	391	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135287
...AEAQSK	391	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135812
...ERSLLA	682	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13743
...ERSLLA	682	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136613
...ERSLLA	682	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136614
...ERSLLA	682	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139136
...PETLV	974	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PETLV	974	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83206

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	365	SVDS.\|.SITD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	391	AQSK.\|.KKEK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	682	SLLA.\|.AMQE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)