O43660: Pleiotropic regulator 1

General Information

Protein names	- Pleiotropic regulator 1
Gene names	PLRG1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43660

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT
        70         80         90        100        110        120
SKENLKEKGP QNATDSYVHK QYPANQGQEV EYFVAGTHPY PPGPGVALTA DTKIQRMPSE
       130        140        150        160        170        180
SAAQSLAVAL PLQTKADANR TAPSGSEYRH PGASDRPQPT AMNSIVMETG NTKNSALMAK
       190        200        210        220        230        240
KAPTMPKPQW HPPWKLYRVI SGHLGWVRCI AVEPGNQWFV TGSADRTIKI WDLASGKLKL
       250        260        270        280        290        300
SLTGHISTVR GVIVSTRSPY LFSCGEDKQV KCWDLEYNKV IRHYHGHLSA VYGLDLHPTI
       310        320        330        340        350        360
DVLVTCSRDS TARIWDVRTK ASVHTLSGHT NAVATVRCQA AEPQIITGSH DTTIRLWDLV
       370        380        390        400        410        420
AGKTRVTLTN HKKSVRAVVL HPRHYTFASG SPDNIKQWKF PDGSFIQNLS GHNAIINTLT
       430        440        450        460        470        480
VNSDGVLVSG ADNGTMHLWD WRTGYNFQRV HAAVQPGSLD SESGIFACAF DQSESRLLTA
       490        500        510
EADKTIKVYR EDDTATEETH PVSWKPEIIK RKRF

Isoforms

- Isoform 2 of Pleiotropic regulator 1

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43660-1-Acetylation	MVEEVQ...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43660-1-Acetylation	MVEEVQ...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101806
O43660-1-unknown	MVEEVQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85613
O43660-1-unknown	MVEEVQ...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O43660-1-	MVEEVQ...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O43660-1-	MVEEVQ...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43660-1-	MVEEVQ...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43660-1-	MVEEVQ...	1			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O43660-1-	MVEEVQ...	1			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O43660-76-	SYVHKQ...	76			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O43660-76-unknown	SYVHKQ...	76		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176838
O43660-109-unknown	TADTKI...	109		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13753
O43660-109-unknown	TADTKI...	109		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197093
O43660-127-	AVALPL...	127			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43660-127-unknown	AVALPL...	127		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173595
O43660-133-unknown	QTKADA...	133		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13754
O43660-133-unknown	QTKADA...	133		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143671

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PGVALT	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13753
...VALPLQ	132	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13754
...VALPLQ	132	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126914
...KRKRF	514	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KRKRF	514	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81231

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	108	VALT.\|.TADT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	132	LPLQ.\|.QTKA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)